Inclusion Criteria:

- > 18 years

- HCC diagnosis :

- histologically or cytologically proven HCC

- or association of the three following criteria:

- cirrhosis

- typical measurable mass (> 3cm, by 2 methods)

- serum alpha-foetoprotein (AFP) ≥500 µg/L

- Cancer Liver Italian Program (CLIP) score : 0 to 3

- Not eligible for specific treatment (surgery, percutaneous ablation or
chemo-embolization)

Exclusion Criteria:

- Glycemia > 2.5 g/L or hypoglycemia

- Extra hepatic life-threatening disease

- Serum creatinin> 120 µmol/L

- Prothrombin time < 50 %

- Platelet count < 50.000 /µL

- Symptomatic cholelithiasis

- Non-measurable tumor