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Prospective Analysis of the Patterns of Immune Reconstitution Following Conventional or High-Dose Chemotherapy With Autologous/Allogeneic Stem Cell Transplant


N/A
N/A
N/A
Open (Enrolling)
Both
Leukemia, Medulloblastoma

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Trial Information

Prospective Analysis of the Patterns of Immune Reconstitution Following Conventional or High-Dose Chemotherapy With Autologous/Allogeneic Stem Cell Transplant


Detailed analysis will be performed at preselected time points following therapy by

- standard flow cytometry in combination with intracellular cytokine/antigen staining

- spectratype analysis

- TREC assays


Inclusion Criteria:



- Acute leukemia treated according to current ALL-BFM 2002 protocol

- Solid tumor treated according to current GPOH-protocol

- Medulloblastoma treated according to HIT-2000 protocol

- High-dose chemotherapy followed by autologous stem cell transplantation

- High-dose chemotherapy followed by allogeneic stem cell transplantation

- Written consent according to our institutional guidelines

Exclusion Criteria:

- No written consent

Type of Study:

Observational

Study Design:

Observational Model: Defined Population, Observational Model: Natural History, Time Perspective: Longitudinal, Time Perspective: Prospective

Principal Investigator

Paul G Schlegel, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University Children's Hospital Pediatric Oncology Wuerzburg / Germany

Authority:

Germany: Ethics Commission

Study ID:

133/04

NCT ID:

NCT00231712

Start Date:

March 2005

Completion Date:

February 2009

Related Keywords:

  • Leukemia
  • Medulloblastoma
  • prospective analysis of immune function,
  • spectratype
  • immunoscope
  • TREC analysis
  • solid tumor
  • Leukemia
  • Medulloblastoma

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