A Pilot Trial Correlating Metabolic Profile of Tamoxifen With Pharmacogenetic Predictors and Clinical Effects
The study will test the following hypotheses.
1. There is a relationship between genetically distinct metabolic profiles of tamoxifen
and the frequency and severity of hot flashes in women on chronic tamoxifen therapy.
2. Genetically distinct metabolic profiles for tamoxifen effect lipid profile, bone
turnover metabolites and bone mineral density, and coagulation factors.
3. Different genetic profiles of estrogen responsive genes influence the pharmacodynamic
effects of tamoxifen in cardiovascular system.
Observational Model: Cohort, Time Perspective: Prospective
David Flockhart, MD, PhD
Indiana University School of Medicine
United States: Federal Government
|Indiana University||Indianapolis, Indiana 46202|
|UMCCC||Ann Arbor, Michigan 48109|