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Stress, Diurnal Cortisol, and Breast Cancer Survival

35 Years
Open (Enrolling)
Breast Cancer

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Trial Information

Stress, Diurnal Cortisol, and Breast Cancer Survival

The purpose of this study is to investigate stress and tonic activation of diurnal cortisol
in aging metastatic breast cancer patients; feedback inhibition & activation of cortisol;
and stress-induced phasic activation of cortisol.

Inclusion Criteria:

1. Diagnosis of recurrent or metastatic breast cancer.

2. Karnofsky of 70% or greater.

3. Proficient enough in English to be able to take questionnaires and participate in the
required tasks.

4. Living within the Greater Bay Area.

5. Age 35 or older .

Exclusion Criteria:

1. Positive supraclavicular lymph nodes as the only metastatic lesion at the time of
initial diagnosis.

2. Active cancers within the past 10 years other than breast cancer, basal cell or
squamous cell carcinomas of the skin, or in situ cancer of the cervix.

3. Any other serious medical condition that will effect short term survival

4. History of major psychiatric illness for which patient was hospitalized or medicated,
with the exception of depression or anxiety

5. A diagnosis of diabetes.

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Principal Investigator

David Spiegel

Investigator Role:

Principal Investigator

Investigator Affiliation:

Stanford University


United States: Food and Drug Administration

Study ID:




Start Date:

September 2002

Completion Date:

December 2012

Related Keywords:

  • Breast Cancer
  • Breast Neoplasms



Stanford University School of Medicine Stanford, California  94305-5317