Early Detection of Pre-cancer Lesions in Adults With Hereditary Nonpolyposis Colorectal Cancer (HNPCC) Syndrome: Assessment of Coloscopy With Chromoscopy Benefit
Patient with HNPCC syndrome confirmed by a mutation (MLH1, MSH2, MHS1) are involved in the
study. Patient have 2 colonoscopy back to back. The second coloscopy is associated to
chromoscopy with carmin indigo. Endoscopist are randomised for the colonoscopy with
chromoscopy and are un-awarded of the result of the first colonoscopy. Histopathology of the
polyp are noted. The follow up were 1 month.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Number of pre-cancer lesions or early cancer detected.
during the procedure
Christophe CELLIER, Pr,MD,PhD
Assistance Publique - Hôpitaux de Paris
France: Ministry of Health