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A Randomized Phase III Study Comparing 5-FU, Leucovorin and Oxaliplatin Versus 5-FU, Leucovorin, Oxaliplatin and Bevacizumab in Patients With Stage II Colon Cancer at High Risk for Recurrence to Determine Prospectively the Prognostic Value of Molecular Markers

Phase 3
18 Years
Open (Enrolling)
Adenocarcinoma of the Colon, Stage II Colon Cancer

Thank you

Trial Information

A Randomized Phase III Study Comparing 5-FU, Leucovorin and Oxaliplatin Versus 5-FU, Leucovorin, Oxaliplatin and Bevacizumab in Patients With Stage II Colon Cancer at High Risk for Recurrence to Determine Prospectively the Prognostic Value of Molecular Markers


I. Compare the 3-year disease-free survival of patients with resected stage II colon cancer
at high risk for recurrence treated with oxaliplatin, leucovorin calcium, and fluorouracil
with vs without bevacizumab.


I. Compare the overall survival of patients treated with these regimens. II. Compare the
toxicity profiles of these regimens in these patients. III. Correlate tumor biologic
characteristics with survival of patients treated with these regimens.

OUTLINE: This is a randomized study. Patients are stratified according to disease stage (IIA
vs IIB) and microsatellite instability (MSI) status (microsatellite stable [MSS] vs low
levels of microsatellite instability [MSI-L]). Patients with disease that is at high risk
for MSI and loss of heterozygosity (LOH) at chromosome 18q are randomized to 1 of 2
treatment arms (arms I and II). Patients with disease that is at low risk for MSI and 18q
LOH are assigned to arm III.

ARM I: Patients receive oxaliplatin IV over 2 hours and leucovorin calcium IV over 2 hours
on day 1. Patients also receive fluorouracil IV bolus followed by fluorouracil IV
continuously over 46 hours beginning on day 1. Treatment repeats every 2 weeks for 12
courses in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive oxaliplatin, leucovorin calcium, and fluorouracil as in arm I and
bevacizumab IV over 30-90 minutes on day 1. Treatment repeats every 2 weeks for 12 courses
in the absence of disease progression or unacceptable toxicity. Patients then receive
bevacizumab alone for 12 additional courses in the absence of disease progression or
unacceptable toxicity.

ARM III: Patients undergo observation only.

Patients are followed every 3 months for 1-2 years, every 6 months for 3 years, and then
annually for up to 10 years from study entry.

Inclusion Criteria:

- Histologically confirmed adenocarcinoma of the colon

- Stage II disease (pT3, pT4a-b, N0, M0)

- At least 8 lymph nodes must have been evaluated

- Meets 1 of the following criteria:

- High risk for microsatellite instability (MSI) and loss of heterozygosity (LOH)
at chromosome 18q

- Microsatellite stable (MSS) with 18q LOH

- MSI-low grade (MSI-L) with 18q LOH

- Low risk for MSI and 18q LOH

- MSS with retention of 18q alleles

- MSI-L with retention of 18q alleles

- MSI-high grade (MSI-H) with retention of 18q alleles

- MSI-H without retention of 18q alleles

- MSI-H with 18q status uninformative

- Distal extent of tumor must be ≥ 12 cm from the anal verge by endoscopy or surgical

- If tumor is located beyond sigmoid colon and centimeter distance is unavailable,
include anatomic region of the colon (e.g., right colon, transverse colon,
hepatic flexure, descending colon, or cecum)

- Has undergone surgical resection of the tumor between the past 28-60 days

- Must have had a complete resection (R0 resection)

- No history of isolated, distant, or noncontiguous intra-abdominal metastases

- Patients with synchronous tumors or appendiceal tumors are ineligible

- Hereditary non-polyposis colorectal cancer allowed

- Paraffin-embedded tumor specimen (one with normal mucosa and one from the resection
tumor) available

- Performance status - ECOG 0-2

- Absolute granulocyte count ≥ 1,500/mm^3*

- Platelet count ≥ 100,000/mm^3*

- No significant bleeding unrelated to tumor within the past 6 months*

- Bilirubin normal (unless due to Gilbert's disease or similar syndrome)*

- Alkaline phosphatase (AP) < 2.5 times upper limit of normal (ULN)*

- AST < 1.5 times ULN*

- PT INR > 1.5* allowed provided the following criteria are met:

- Patient is on full-dose anticoagulants

- INR in range (usually 2-3) on a stable dose of warfarin or low molecular weight

- No active bleeding or pathological condition associated with a high risk of
bleeding unrelated to primary colon tumor

- No systemic hepatic disease*

- Creatinine ≤ 1.5 times ULN*

- Urine protein:creatinine ratio < 1.0*

- Urine protein < 1 gm on 24-hour urine collection*

- No systemic renal disease*

- History of hypertension allowed provided blood pressure < 150/90 mm Hg while on a
stable regimen of anti-hypertensive therapy*

- No New York Heart Association class III or IV cardiac disease*

- No symptomatic arrhythmia*

- No history of transient ischemic attack*

- No history of cerebrovascular accident*

- No symptomatic peripheral vascular disease*

- No arterial thromboembolic events within the past 12 months*

- No unstable angina within the past 12 months*

- No myocardial infarction within the past 12 months*

- No other systemic cardiovascular disease*

- Not pregnant or nursing*

- Negative pregnancy test*

- Fertile patients must use effective contraception during and for 3 months after
completion of study treatment*

- No active gastroduodenal ulcer by endoscopy*

- No complete obstruction or perforation of the bowel

- No history of inflammatory bowel disease

- No prior or concurrent malignancy except for nonmelanoma skin cancer, carcinoma in
situ of the cervix, breast cancer in situ, treated non-pelvic cancer from which the
patient has been disease-free for > 5 years, or history of breast cancer (without
evidence of disease) and remain on hormonal therapy for > 5 years

- No other nonmalignant systemic disease that would preclude study compliance*

- No psychiatric or addictive disorder or other condition that would preclude study

- No serious or non-healing wound, skin ulcer, or bone fracture*

- No peripheral neuropathy ≥ grade 2*

- No significant traumatic injury within the past 4 weeks*

- No known allergy to platinum compounds

- No prior radiotherapy for this cancer

- No prior systemic therapy for this cancer

- More than 28 days since prior major surgery or open biopsy*

- More than 7 days since prior core biopsy or other minor procedure except placement of
a vascular access device*

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Disease-free survival

Outcome Description:

A stratified log-rank test, with stratification on stage (IIA versus IIB) and MSI status (MSS versus MSI-L) will be used.

Outcome Time Frame:

3 years

Safety Issue:


Principal Investigator

Al Benson

Investigator Role:

Principal Investigator

Investigator Affiliation:

Eastern Cooperative Oncology Group


United States: Food and Drug Administration

Study ID:




Start Date:

August 2005

Completion Date:

Related Keywords:

  • Adenocarcinoma of the Colon
  • Stage II Colon Cancer
  • Adenocarcinoma
  • Adenocarcinoma, Mucinous
  • Colonic Neoplasms



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Colorado Cancer Research Program CCOP Denver, Colorado  80224-2522
Saint Mary's Hospital and Regional Medical Center Grand Junction, Colorado  81502
Saint Mary Corwin Medical Center Pueblo, Colorado  81004
Danbury Hospital Danbury, Connecticut  06810
Saint Francis Hospital and Medical Center Hartford, Connecticut  06105
The Hospital of Central Connecticut New Britain, Connecticut  06050
Stamford Hospital Stamford, Connecticut  06904
Bayhealth Medical Center at Kent General Dover, Delaware  19901
Edna Williams Cancer Center at the Baptist Cancer Institute Jacksonville, Florida  32207
Cancer Centers of Central Florida PA Leesburg, Florida  34788
Phoebe Putney Memorial Hospital Albany, Georgia  31703
Atlanta Regional CCOP Atlanta, Georgia  30342
Well Star Cobb Hospital Austell, Georgia  30106
John B Amos Cancer Center Columbus, Georgia  31904
Veterans Administration Medical Center Decatur, Georgia  30033
Wellstar Kennestone Hospital Marietta, Georgia  30060
Saint Joseph's-Candler Health System Savannah, Georgia  31405
Oncare Hawaii Inc-POB II Honolulu, Hawaii  96813
Oncare Hawaii Inc-Kuakini Honolulu, Hawaii  96817
University of Hawaii Honolulu, Hawaii  96813
Pacific Cancer Institute of Maui Wailuku, Hawaii  96793
Saint Luke's Mountain States Tumor Institute Boise, Idaho  83712
Saint Anthony's Health Alton, Illinois  62002
Rush - Copley Medical Center Aurora, Illinois  60504
John H Stroger Jr Hospital of Cook County Chicago, Illinois  60612-3785
Saint Francis Hospital Evanston, Illinois  60202
Evanston CCOP-NorthShore University HealthSystem Evanston, Illinois  60201
Hopedale Medical Complex - Hospital Hopedale, Illinois  61747
Joliet Oncology-Hematology Associates Limited Joliet, Illinois  60435
Midwest Center for Hematology Oncology Joliet, Illinois  60432
Provena Saint Mary's Hospital Kankakee, Illinois  60901
North Shore Hematology Oncology Libertyville, Illinois  60048
Vigliotti, Antonio, P.G. M.D. (UIA Investigator) Moline, Illinois  61265
Stoffel, Thomas J MD (UIA Investigator) Moline, Illinois  61265
Garneau, Stewart C MD (UIA Investigator) Moline, Illinois  61265
Sharis, Christine M MD (UIA Investigator) Moline, Illinois  61265
Porubcin, Michael MD (UIA Investigator) Moline, Illinois  61265
Good Samaritan Regional Medical Center Mt. Vernon, Illinois  62864
Hematology Oncology Consultants Limited Naperville, Illinois  60540
Community Cancer Center Foundation Normal, Illinois  61761
Illinois CancerCare-Ottawa Clinic Ottawa, Illinois  61350
Ottawa Regional Hospital and Healthcare Center Ottawa, Illinois  61350
Pekin Cancer Treatment Center Pekin, Illinois  61554
Illinois Oncology Research Association CCOP Peoria, Illinois  61615
Illinois CancerCare-Peoria Peoria, Illinois  61615
Illinois Valley Hospital Peru, Illinois  61354
Hematology Oncology Associates of Illinois - Skokie Skokie, Illinois  60076
Midwest Cancer Research Group Incorporated Skokie, Illinois  60077
Edward H Kaplan MD and Associates Skokie, Illinois  60076
Saint Margaret's Hospital Spring Valley, Illinois  61362
Carle Clinic-Urbana Main Urbana, Illinois  61801
Saint Francis Hospital and Health Centers Beech Grove, Indiana  46107
Fort Wayne Medical Oncology and Hematology Inc - State Boulevard Fort Wayne, Indiana  46845
Wishard Hospital Indianapolis, Indiana  46202
Saint Anthony Memorial Health Center Michigan City, Indiana  46360
Reid Hospital and Health Care Services Richmond, Indiana  47374
McFarland Clinic Ames, Iowa  50010
Hematology Oncology Associates-Quad Cities Bettendorf, Iowa  52722
Constantinou, Costas L MD (UIA Investigator) Bettendorf, Iowa  52722
Cedar Rapids Oncology Association Cedar Rapids, Iowa  52403
Mercy Hospital Cedar Rapids, Iowa  52403
Medical Oncology and Hematology Associates-West Des Moines Clive, Iowa  50325
Genesis Medical Center - East Campus Davenport, Iowa  52803
Iowa Oncology Research Association CCOP Des Moines, Iowa  50309
Mercy Capitol Des Moines, Iowa  50307
Mercy Medical Center - Des Moines Des Moines, Iowa  50314
Medical Oncology and Hematology Associates-Des Moines Des Moines, Iowa  50309
Mercy Medical Center - North Iowa Mason City, Iowa  50401
Mercy Medical Center-Sioux City Sioux City, Iowa  51104
Saint Luke's Regional Medical Center Sioux City, Iowa  51104
Cancer Center of Kansas - El Dorado El Dorado, Kansas  67042
Cancer Center of Kansas-Kingman Kingman, Kansas  67068
Cancer Center of Kansas - Parsons Parsons, Kansas  67357
Cancer Center of Kansas - Pratt Pratt, Kansas  67124
Stormont-Vail Regional Health Center Topeka, Kansas  66604
Saint Francis Hospital and Medical Center - Topeka Topeka, Kansas  66606
Cancer Center of Kansas-Wichita Medical Arts Tower Wichita, Kansas  67208
Cancer Center of Kansas - Main Office Wichita, Kansas  67214
Our Lady Bellefonte Hospital Ashland, Kentucky  41101
Ochsner Clinic Foundation-Baton Rouge Baton Rouge, Louisiana  70809
DeSoto Regional Health System Mansfield, Louisiana  71052
Louisiana State University Sciences Center- Monroe Monroe, Louisiana  71210
Medical Center of Louisiana New Orleans, Louisiana  70112
Highland Clinic Shreveport, Louisiana  71105
Lawrence Memorial Medford, Massachusetts  02155
Holy Family Hospital Methuen, Massachusetts  01844
Norwood Hospital Norwood, Massachusetts  02062
Commonwealth Hematology Oncology PC-Quincy Quincy, Massachusetts  02169
Hickman Cancer Center Adrian, Michigan  49221
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor, Michigan  48106
Oakwood Hospital Dearborn, Michigan  48123
Saint John Hospital and Medical Center Detroit, Michigan  48236
Michigan State University - Breslin Cancer Center East Lansing, Michigan  48824-1313
Green Bay Oncology - Escanaba Escanaba, Michigan  49431
McLaren Regional Medical Center Flint, Michigan  48532
Grand Rapids Clinical Oncology Program Grand Rapids, Michigan  49503
Saint Mary's Health Care Grand Rapids, Michigan  49503
Spectrum Health at Butterworth Campus Grand Rapids, Michigan  49503
Green Bay Oncology - Iron Mountain Iron Mountain, Michigan  49801
Allegiance Health Jackson, Michigan  49201
Ingham Regional Medical Center Lansing, Michigan  48910
Sparrow Hospital Lansing, Michigan  48912
Saint Mary Mercy Hospital Livonia, Michigan  48154
Mercy Memorial Hospital Monroe, Michigan  48162
Mercy Health Partners-Mercy Campus Muskegon, Michigan  49443
Mercy Health Partners-Hackley Campus Muskegon, Michigan  49442
Saint Joseph Mercy Oakland Pontiac, Michigan  48341-2985
Saint Joseph Mercy Port Huron Port Huron, Michigan  48060
Saint Mary's of Michigan Saginaw, Michigan  48601
Lakeland Hospital St. Joseph, Michigan  49085
Saint John Macomb-Oakland Hospital Warren, Michigan  48093
Medini, Eitan MD (UIA Investigator) Alexandria, Minnesota  56308
Miller-Dwan Hospital Duluth, Minnesota  55805
Saint Luke's Hospital of Duluth Duluth, Minnesota  55805
Etzell, Paul S MD (UIA Investigator) Fergus Falls, Minnesota  56537
Swenson, Wade II, MD (UIA Investigator) Fergus Falls, Minnesota  56537
Unity Hospital Fridley, Minnesota  55432
Immanuel-Saint Joseph Hospital-Mayo Health System Mankato, Minnesota  56002
Saint John's Hospital - Healtheast Maplewood, Minnesota  55109
Minnesota Oncology Hematology PA-Maplewood Maplewood, Minnesota  55109
Minneapolis Veterans Medical Center Minneapolis, Minnesota  55417
North Memorial Medical Health Center Robbinsdale, Minnesota  55422
Saint Cloud Hospital Saint Cloud, Minnesota  56303
Park Nicollet Clinic - Saint Louis Park Saint Louis Park, Minnesota  55416
Saint Joseph's Hospital - Healtheast Saint Paul, Minnesota  55102
Minnesota Oncology and Hematology PA-Woodbury Woodbury, Minnesota  55125
Southeast Missouri Hospital Cape Girardeau, Missouri  63701
Freeman Health System Joplin, Missouri  64804
Saint Anthony's Medical Center Saint Louis, Missouri  63128
Saint Louis-Cape Girardeau CCOP Saint Louis, Missouri  63141
Missouri Baptist Medical Center Saint Louis, Missouri  63131
Saint John's Mercy Medical Center Saint Louis, Missouri  63141
Ozark Health Ventures LLC dba Cancer Research for The Ozarks Springfield Springfield, Missouri  65802
Saint John's Hospital Springfield, Missouri  65804
Cox Medical Center Springfield, Missouri  65807
Hematology-Oncology Centers of the Northern Rockies PC Billings, Montana  59101
Saint Vincent Healthcare Billings, Montana  59101
Deaconess Medical Center Billings, Montana  59107
Billings Clinic Billings, Montana  59107-7000
Internal Medicine of Bozeman Bozeman, Montana  59715
Saint James Community Hospital and Cancer Treatment Center Butte, Montana  59701
Benefis Healthcare- Sletten Cancer Institute Great Falls, Montana  59405
Berdeaux, Donald MD (UIA Investigator) Great Falls, Montana  59405
Saint Peter's Community Hospital Helena, Montana  59601
Glacier Oncology PLLC Kalispell, Montana  59901
Community Medical Hospital Missoula, Montana  59801
Saint Patrick Hospital - Community Hospital Missoula, Montana  59802
Good Samaritan Hospital Kearney, Nebraska  68847
Lincoln Medical Education Foundation Cancer Resource Center Lincoln, Nebraska  68510
Missouri Valley Cancer Consortium CCOP Omaha, Nebraska  68106
Nevada Cancer Research Foundation CCOP Las Vegas, Nevada  89106
New Hampshire Oncology Hematology Associates Hooksett, New Hampshire  03106
LRGHealthcare-Lakes Region General Hospital Laconia, New Hampshire  03246
Elliot Hospital Manchester, New Hampshire  03103
Portsmouth Regional Hospital Portsmouth, New Hampshire  03802
Ocean Medical Center Brick, New Jersey  08724
Cooper Hospital University Medical Center Camden, New Jersey  08103
Veterans Adminstration New Jersey Health Care System East Orange, New Jersey  07018-1095
Hunterdon Medical Center Flemington, New Jersey  08822
Saint Barnabas Medical Center Livingston, New Jersey  07039
Mountainside Hospital Montclair, New Jersey  07042
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County Mount Holly, New Jersey  08060
Sparta Cancer Treatment Center Sparta, New Jersey  07871
South Jersey Healthcare Vineland, New Jersey  08360
Virtua West Jersey Hospital Voorhees Voorhees, New Jersey  08043
The North Division of Montefiore Medical Center Bronx, New York  10466
Veterans Affairs Western New York Health Care System-Buffalo Buffalo, New York  14215
Orange Regional Medical Center Middletown, New York  10940
New York University Langone Medical Center New York, New York  10016
Saint Luke's Roosevelt Hospital Center - Saint Luke's Division New York, New York  10025
Interlakes Foundation Inc-Rochester Rochester, New York  14623
State University of New York Upstate Medical University Syracuse, New York  13210
Faxton-Saint Luke's Healthcare Utica, New York  13502
Mission Hospitals Inc Asheville, North Carolina  28801
Alamance Regional Medical Center Burlington, North Carolina  27216
Wayne Memorial Hospital Goldsboro, North Carolina  27534
Kinston Medical Specialists PA Kinston, North Carolina  28501
Saint Alexius Medical Center Bismarck, North Dakota  58501
Summa Barberton Hospital Barberton, Ohio  44203
Aultman Health Foundation Canton, Ohio  44710
Doctors Hospital Columbus, Ohio  43228
Grant Medical Center Columbus, Ohio  43215
Mount Carmel Health Center West Columbus, Ohio  43222
Good Samaritan Hospital - Dayton Dayton, Ohio  45406
Dayton CCOP Dayton, Ohio  45429
Samaritan North Health Center Dayton, Ohio  45415
Veteran Affairs Medical Center Dayton, Ohio  45428
Hematology Oncology Center Incorporated Elyria, Ohio  44035
Blanchard Valley Hospital Findlay, Ohio  45840
Atrium Medical Center-Middletown Regional Hospital Franklin, Ohio  45005-1066
Cleveland Clinic Cancer Center Independence Independence, Ohio  44131
Cole, Sharon, K. M.D. (UIA Investigator) Kenton, Ohio  43326
Kettering Medical Center Kettering, Ohio  45429
Mansfield General Hospital-MedCentral Health System Mansfield, Ohio  44903
Marietta Memorial Hospital Marietta, Ohio  45750
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center Maumee, Ohio  43537
Saint Charles Hospital Oregon, Ohio  43616
North Coast Cancer Care Sandusky, Ohio  44870
Toledo Community Hospital Oncology Program CCOP Toledo, Ohio  43617
Mercy Cancer Center at Saint Anne Mercy Hospital Toledo, Ohio  43623
University of Toledo Toledo, Ohio  43614
Saint Vincent Mercy Medical Center Toledo, Ohio  43608
Upper Valley Medical Center Troy, Ohio  45373
Saint Ann's Hospital Westerville, Ohio  43081
Cleveland Clinic Wooster Specialty Center Wooster, Ohio  44691
Wright-Patterson Medical Center Wright-Patterson Afb, Ohio  45433-5529
Genesis HealthCare System Zanesville, Ohio  43701
Natalie W Bryant Cancer Center Tulsa, Oklahoma  74136
Providence Saint Vincent Medical Center Portland, Oregon  97225
Columbia River Oncology Program Portland, Oregon  97225
Salem Hospital Salem, Oregon  97309
Saint Luke's Hospital Bethlehem, Pennsylvania  18015
Pocono Medical Center East Stroudsburg, Pennsylvania  18301
Ephrata Cancer Center Ephrata, Pennsylvania  17522
Riddle Hospital Media, Pennsylvania  19063
Pottstown Memorial Medical Center Pottstown, Pennsylvania  19464
Hematology and Oncology Associates of North East Pennsylvania Scranton, Pennsylvania  18508
Scranton Hematology Oncology Scranton, Pennsylvania  18510
Mercy Hospital Scranton, Pennsylvania  18501
Associates In Hematology Oncology PC-Upland Upland, Pennsylvania  19013
Mainline Health CCOP Wynnewood, Pennsylvania  19096
Hematology and Oncology Associates of Rhode Island Inc Cranston, Rhode Island  02920
Kent County Hospital Warwick, Rhode Island  02886
AnMed Health Hospital Anderson, South Carolina  29621
Greenville CCOP Greenville, South Carolina  29615
Greenville Memorial Hospital Greenville, South Carolina  29605
Upstate Carolina CCOP Spartanburg, South Carolina  29303
Sanford Cancer Center-Oncology Clinic Sioux Falls, South Dakota  57104
The Don and Sybil Harrington Cancer Center Amarillo, Texas  79106
Veterans Administration Medical Center Houston, Texas  77030
Saint Luke's Episcopal Hospital Houston, Texas  77030
Cancer Therapy and Research Center at The UT Health Science Center at San Antonio San Antonio, Texas  78229
Audie L Murphy Veterans Affairs Hospital San Antonio, Texas  78209
University Hospital San Antonio, Texas  78229
Southwestern Oncology Research Department Bennington, Vermont  05201
Fredericksburg Oncology Inc Fredericksburg, Virginia  22401
Southwest VA Regional Cancer Center Norton, Virginia  24273
Auburn Regional Medical Center Auburn, Washington  98002
Harrison Bremerton Hematology and Oncology Bremerton, Washington  98310
Saint Francis Hospital Federal Way, Washington  98003
Columbia Basin Hematology and Oncology PLLC Kennewick, Washington  99336
Providence - Saint Peter Hospital Olympia, Washington  98506-5166
Good Samaritan Community Hospital Puyallup, Washington  98372
Minor and James Medical PLLC Seattle, Washington  98104
The Polyclinic Seattle, Washington  98122
Swedish Medical Center-First Hill Seattle, Washington  98122-4307
Northwest CCOP Tacoma, Washington  98405
Multicare Health System Tacoma, Washington  98415
Saint Clare Hospital Tacoma, Washington  98499
Saint Joseph Medical Center Tacoma, Washington  98405
Edwards Comprehensive Cancer Center Huntington, West Virginia  25701
West Virginia University Morgantown, West Virginia  26506
Sacred Heart Hospital Eau Claire, Wisconsin  54701
Central Wisconsin Cancer Program Fond Du Lac, Wisconsin  54935
Saint Vincent Hospital Green Bay, Wisconsin  54301
Green Bay Oncology Limited at Saint Mary's Hospital Green Bay, Wisconsin  54303
Saint Mary's Hospital Green Bay, Wisconsin  54303
Green Bay Oncology at Saint Vincent Hospital Green Bay, Wisconsin  54301-3526
Aurora BayCare Medical Center Green Bay, Wisconsin  54311-6519
Dean Hematology and Oncology Clinic Madison, Wisconsin  53717
UW Health Oncology - 1 South Park Madison, Wisconsin  53715
Vince Lombardi Cancer Clinic-Marinette Marinette, Wisconsin  54143
Bay Area Medical Center Marinette, Wisconsin  54143
Marshfield Clinic-Minocqua Center Minocqua, Wisconsin  54548
Oconomowoc Memorial Hospital-ProHealth Care Inc Oconomowoc, Wisconsin  53066-3896
Green Bay Oncology - Oconto Falls Oconto Falls, Wisconsin  54154
Marshfield Clinic at James Beck Cancer Center Rhinelander, Wisconsin  54501
Marshfield Clinic-Rice Lake Center Rice Lake, Wisconsin  54868
Saint Michael's Hospital Stevens Point, Wisconsin  54481
Green Bay Oncology - Sturgeon Bay Sturgeon Bay, Wisconsin  54235
Marshfield Clinic-Wausau Center Wausau, Wisconsin  54401
Aspirus Regional Cancer Center Wausau, Wisconsin  54401
Olathe Cancer Center Olathe, Kansas  66061
Jupiter Medical Center Jupiter, Florida  33458
University of Illinois Chicago, Illinois  60612
Hamot Medical Center Erie, Pennsylvania  16550
York Hospital York, Maine  03909
Elkhart Clinic Elkhart, Indiana  46515
John Muir Medical Center-Concord Campus Concord, California  94520
Washington Hospital Fremont, California  94538
Saint Jude Medical Center Fullerton, California  92835
Marin General Hospital Greenbrae, California  94904
Veterans Affairs Loma Linda Healthcare System Loma Linda, California  92357
University of Colorado Cancer Center - Anschutz Cancer Pavilion Aurora, Colorado  80045
Denver Veterans Administration Medical Center Denver, Colorado  80220
The Shaw Regional Cancer Center Edwards, Colorado  81632
Montrose Memorial Hospital Montrose, Colorado  81401
Memorial Healthcare System - Joe DiMaggio Children's Hospital Hollywood, Florida  33021
Mount Sinai Medical Center CCOP Miami Beach, Florida  33140
Northeast Georgia Cancer Care LLC Athens, Georgia  30607
Harbin Clinic Medical Oncology and Clinical Research Rome, Georgia  30165
Portneuf Medical Center Pocatello, Idaho  83201
Kootenai Cancer Center Post Falls, Idaho  83854
Illinois CancerCare-Bloomington Bloomington%, Illinois  61701
Illinois CancerCare-Canton Canton, Illinois  61520
Illinois CancerCare-Carthage Carthage, Illinois  62321
Jesse Brown Veterans Affairs Medical Center Chicago, Illinois  60612
Illinois CancerCare-Eureka Eureka, Illinois  61530
Illinois CancerCare-Cottage Galesburg, Illinois  61401
Delnor Community Hospital Geneva, Illinois  60134
Illinois CancerCare-Havana Havana, Illinois  62644
Illinois CancerCare-Kewanee Clinic Kewanee, Illinois  61443
Illinois CancerCare-Macomb Macomb, Illinois  61455
Illinois CancerCare-Monmouth Monmouth, Illinois  61462
DuPage Medical Group-Ogden Naperville, Illinois  60563
Illinois CancerCare-Community Cancer Center Normal, Illinois  61761
Illinois CancerCare-Pekin Pekin, Illinois  61603
Illinois CancerCare-Peru Peru, Illinois  61354
Illinois CancerCare-Princeton Princeton, Illinois  61356
Illinois CancerCare-Spring Valley Spring Valley, Illinois  61362
Michiana Hematology Oncology PC-Elkhart Elkhart, Indiana  46514
Michiana Hematology Oncology PC-Plymouth Plymouth, Indiana  46563
Michiana Hematology Oncology PC-South Bend South Bend, Indiana  46601
Michiana Hematology Oncology-PC Westville Westville, Indiana  46391
Cancer Center of Kansas-Liberal Liberal, Kansas  67901
Saint Mary's Regional Medical Center Lewiston, Maine  04240
Maine Medical Center- Scarborough Campus Scarborough, Maine  04074
Saint Agnes Hospital Baltimore, Maryland  21229
The Memorial Hospital at Easton Easton, Maryland  21601
Memorial Hospital at Easton - Shore Regional Cancer Center Easton, Maryland  21601
Commonwealth Hematology Oncology PC-Concord Concord, Massachusetts  01742
Commonwealth Hematology Oncology PC-Haverhill Haverhill, Massachusetts  01830
Commonwealth Hematology Oncology PC-Lawrence Lawrence, Massachusetts  01842
Commonwealth Hematology Oncology PC-Stoneham Stoneham, Massachusetts  02180
Commonwealth Hematology Oncology PC-Weymouth Weymouth, Massachusetts  02190
Commonwealth Hematology Oncology PC-Worcester Worcester, Massachusetts  01605
University of Michigan University Hospital Ann Arbor, Michigan  48109
Michiana Hematology Oncology PC-Niles Niles, Michigan  49120
Central Care Cancer Center-Carrie J Babb Cancer Center Bolivar, Missouri  65613
Skaggs Cancer Center Branson, Missouri  65616
University of Missouri - Ellis Fischel Columbia, Missouri  65203
Veterans Administration Columbia, Missouri  65201
Renown Regional Medical Center Reno, Nevada  89502
John F Kennedy Medical Center Edison, New Jersey  08818
Hackensack University Medical CCOP Hackensack, New Jersey  07601
UMDNJ - New Jersey Medical School Newark, New Jersey  07103
AtlantiCare Regional Medical Center -Main Campus Pomona, New Jersey  08240
Syracuse Veterans Administration Medical Center Syracuse, New York  13210
Carolinas Medical Center - Northeast Concord, North Carolina  28025
Moses Cone Health System-Regional Cancer Center Greensboro, North Carolina  27403
East Carolina University Greenville, North Carolina  27858
Maria Parham Hospital Henderson, North Carolina  27536
Rex Cancer Center Raleigh, North Carolina  27607
Duke Raleigh Hospital Raleigh, North Carolina  27609
Annie Penn Memorial Hospital Reidsville, North Carolina  27320
North Coast Cancer Care-Clyde Clyde, Ohio  43410
Community Health Partners Regional Medical Center Elyria, Ohio  44035
Stark, Michael, Edward. M.D. (UIA Investigator) Toledo, Ohio  43623
Saint John Medical Center Tulsa, Oklahoma  74104
Oncology Hematology Associates of Northern Pennsylvania Dubois, Pennsylvania  15801
The Regional Cancer Center Erie, Pennsylvania  16505
Armstrong Center for Medicine and Health Kittanning, Pennsylvania  16201
Saint Mary Medical and Regional Cancer Center Langhorne, Pennsylvania  19047
Chestnut Hill Health System Philadelphia, Pennsylvania  19118
Roper Hospital Charleston, South Carolina  29401
Cancer Centers of the Carolinas - Faris Greenville, South Carolina  29605
Cancer Centers of the Carolinas-Greer Radiation Oncology Greer, South Carolina  29650
Cancer Centers of the Carolinas-Greer Medical Oncology Greer, South Carolina  29650
Erlanger Medical Center Chattanooga, Tennessee  37403
Vanderbilt-Ingram Cancer Center Cool Springs Franklin, Tennessee  37067
The Center for Biomedical Research Knoxville, Tennessee  37909
East Tennessee Baptist Hospital-Mercy Health Partners Knoxville, Tennessee  37920
University of Tennessee - Knoxville Knoxville, Tennessee  37920
Nashville Oncology Associates PC Nashville, Tennessee  37203
Texas Oncology-Austin North Austin, Texas  78759
Texas Oncology-Austin Midtown Austin, Texas  78705
Texas Oncology - Central Austin Cancer Center Austin, Texas  78731
Texas Oncology - South Austin Cancer Center Austin, Texas  78745
Texas Oncology-Cedar Park Cedar Park, Texas  78613
Saint Paul Hospital Dallas, Texas  75235
Texas Oncology-Seton Williamson Round Rock, Texas  78665
Texas Oncology - Round Rock Cancer Center Round Rock, Texas  78681
Texas Oncology- San Marcos San Marcos, Texas  78666
Sandra L Maxwell Cancer Center Cedar City, Utah  84720
Intermountain Medical Center Murray, Utah  84157
Utah Valley Regional Medical Center Provo, Utah  84603
Dixie Medical Center Regional Cancer Center Saint George, Utah  84770
Intermountain Health Care Salt Lake City, Utah  84103
Utah Cancer Specialists-Salt Lake City Salt Lake City, Utah  84106
Southwestern Vermont Medical Center Bennington, Vermont  05201
Mount Ascutney Hospital and Health Center Windsor, Vermont  05089
Virginia Oncology Associates-Hampton Hampton, Virginia  23666
Skagit Valley Hospital Mt. Vernon, Washington  98273
Evergreen Hematology and Oncology PS Spokane, Washington  99218
West Virginia University Charleston Charleston, West Virginia  25304
Marshfield Clinic-Chippewa Center Chippewa Falls, Wisconsin  54729
Holy Family Memorial Hospital Manitowoc, Wisconsin  54221
Aurora Advanced Healthcare Inc-Mequon Mequon, Wisconsin  53092
Wheaton Franciscan Healthcare - Saint Joseph Milwaukee, Wisconsin  53210
Medical Consultants Limited Milwaukee, Wisconsin  53215
Wheaton Franciscan Cancer Care - All Saints Racine, Wisconsin  53405
Vince Lombardi Cancer Clinic-Sheboygan Sheboygan, Wisconsin  53081
Vince Lombardi Cancer Clinic - Slinger Slinger, Wisconsin  53086
Marshfield Clinic Cancer Care at Saint Michael's Hospital Stevens Point, Wisconsin  54481
Aurora Medical Center in Summit Summit, Wisconsin  53066
Vince Lombardi Cancer Clinic Two Rivers, Wisconsin  54241
Riverview Hospital Wisconsin Rapids, Wisconsin  54494
Cancer Centers of Southwest Oklahoma Research Lawton, Oklahoma  
San Francisco General Hospital San Francisco, California  94110
Stanford University Hospitals and Clinics Stanford, California  94305
Siouxland Hematology Oncology Associates Sioux City, Iowa  51101
IU Health Arnett Lafayette, Indiana  
Georgia Health Sciences University Augusta, Georgia  30912
Alta Bates Summit Medical Center-Herrick Campus Berkeley, California  94704
Boca Raton Regional Hospital Boca Raton, Florida  33486
Carle Foundation - Carle Cancer Center Urbana, Illinois  61801
Michiana Hematology Oncology PC-Mishawaka Mishawaka, Indiana  46545-1470
Oncology Associates at Mercy Medical Center Cedar Rapids, Iowa  52403
Marie Yeager Cancer Center Saint Joseph, Michigan  49085
Sanford Clinic North-Fargo Fargo, North Dakota  58102
Sanford Medical Center-Fargo Fargo, North Dakota  58122
Summa Akron City Hospital Akron, Ohio  44304
The Toledo Hospital/Toledo Children's Hospital Toledo, Ohio  43606
Sanford USD Medical Center - Sioux Falls Sioux Falls, South Dakota  57117-5134
Providence Sacred Heart Medical Center and Children's Hospital Spokane, Washington  99204
Genesys Regional Medical Center-West Flint Campus Flint, Michigan  48532
Sanford Clinic North-Bemidgi Bemidji, Minnesota  56601
Essentia Health Duluth Clinic CCOP Duluth, Minnesota  55805
Essentia Health Saint Mary's Medical Center Duluth, Minnesota  55805
Sanford Bismarck Medical Center Bismarck, North Dakota  58501
Toledo Clinic Cancer Centers-Oregon Oregon, Ohio  43616
Veterans Administration-San Diego Medical Center San Diego, California  92161
Community Howard Regional Health Kokomo, Indiana  46904
Indiana University Health La Porte Hospital La Porte, Indiana  46350
Saint Joseph Regional Medical Center-Mishawaka Mishawaka, Indiana  46545-1470
Essentia Health Cancer Center-South University Clinic Fargo, North Dakota  58103
PeaceHealth Saint Joseph Medical Center Bellingham, Washington  98225
Group Health Cooperative of Puget Sound Oncology Consortium Seattle, Washington  98109
Aurora Cancer Care-Burlington Burlington, Wisconsin  53105
Aurora Cancer Care-Franklin Franklin, Wisconsin  53132
Aurora Cancer Care-Glendale Glendale, Wisconsin  53212
Aurora Cancer Care-Kenosha South Kenosha, Wisconsin  53142
Aurora Cancer Care-Milwaukee South Milwaukee, Wisconsin  53215
Aurora Cancer Care-Racine Racine, Wisconsin  53406-5661
Aurora Cancer Care-Waukesha Waukesha, Wisconsin  53188
Aurora Cancer Care-Milwaukee West Wauwatosa, Wisconsin  53226
Christiana Care Health System-Christiana Hospital Newark, Delaware  19718
Illinois Cancer Specialists-Niles Niles, Illinois  60714
Bronson Battle Creek Battle Creek, Michigan  49017
Riverview Medical Center/Booker Cancer Center Red Bank, New Jersey  07701
Springfield Regional Medical Center Springfield, Ohio  45505
Cancer Specialists of North Florida-Orange Park Orange Park, Florida  32073
The James Graham Brown Cancer Center at University of Louisville Louisville, Kentucky  40202
NEA Baptist Memorial Hospital Jonesboro, Arkansas  72401
Marin Cancer Care Inc Greenbrae, California  94904
Augusta Oncology Associates PC-Saint Sebastian Augusta, Georgia  30901
Edward Hospital/Cancer Center Naperville, Illinois  60540
Promise Regional Medical Center-Hutchinson Hutchinson, Kansas  65702
Saint Vincent Hospital/Reliant Medical Group Worcester, Massachusetts  01608
Lake Region Healthcare Corporation-Cancer Care Fergus Falls, Minnesota  56537
Saint Louis Cancer and Breast Institute-South City Saint Louis, Missouri  63109
Nevada Cancer Institute-Summerlin Campus Las Vegas, Nevada  89135
Toledo Clinic Cancer Centers-Bowling Green Bowling Green, Ohio  43402
Toledo Clinic Cancer Centers-Maumee Maumee, Ohio  43537-1839
Toledo Clinic Cancer Centers-Toledo Toledo, Ohio  43623
PinnacleHealth Fox Chase Regional Cancer Center at Polyclinic Hospital Harrisburg, Pennsylvania  17110
Guthrie Clinic-Robert Packer Hospital Sayre, Pennsylvania  18840
Self Regional Healthcare Greenwood, South Carolina  29646
Harrison Poulsbo Hematology and Oncology Poulsbo, Washington  98370
Providence Holy Family Hospital Spokane, Washington  99208
PeaceHealth Southwest Medical Center Vancouver, Washington  98664
Aurora Cancer Care-Southern Lakes Elkhorn, Wisconsin  53121
Mayo Clinic Health System-Franciscan Healthcare La Crosse, Wisconsin  54601