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A Randomized Phase III Study Comparing 5-FU, Leucovorin and Oxaliplatin Versus 5-FU, Leucovorin, Oxaliplatin and Bevacizumab in Patients With Stage II Colon Cancer at High Risk for Recurrence to Determine Prospectively the Prognostic Value of Molecular Markers


Phase 3
18 Years
N/A
Open (Enrolling)
Both
Adenocarcinoma of the Colon, Stage II Colon Cancer

Thank you

Trial Information

A Randomized Phase III Study Comparing 5-FU, Leucovorin and Oxaliplatin Versus 5-FU, Leucovorin, Oxaliplatin and Bevacizumab in Patients With Stage II Colon Cancer at High Risk for Recurrence to Determine Prospectively the Prognostic Value of Molecular Markers


PRIMARY OBJECTIVES:

I. Compare the 3-year disease-free survival of patients with resected stage II colon cancer
at high risk for recurrence treated with oxaliplatin, leucovorin calcium, and fluorouracil
with vs without bevacizumab.

SECONDARY OBJECTIVES:

I. Compare the overall survival of patients treated with these regimens. II. Compare the
toxicity profiles of these regimens in these patients. III. Correlate tumor biologic
characteristics with survival of patients treated with these regimens.

OUTLINE: This is a randomized study. Patients are stratified according to disease stage (IIA
vs IIB) and microsatellite instability (MSI) status (microsatellite stable [MSS] vs low
levels of microsatellite instability [MSI-L]). Patients with disease that is at high risk
for MSI and loss of heterozygosity (LOH) at chromosome 18q are randomized to 1 of 2
treatment arms (arms I and II). Patients with disease that is at low risk for MSI and 18q
LOH are assigned to arm III.

ARM I: Patients receive oxaliplatin IV over 2 hours and leucovorin calcium IV over 2 hours
on day 1. Patients also receive fluorouracil IV bolus followed by fluorouracil IV
continuously over 46 hours beginning on day 1. Treatment repeats every 2 weeks for 12
courses in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive oxaliplatin, leucovorin calcium, and fluorouracil as in arm I and
bevacizumab IV over 30-90 minutes on day 1. Treatment repeats every 2 weeks for 12 courses
in the absence of disease progression or unacceptable toxicity. Patients then receive
bevacizumab alone for 12 additional courses in the absence of disease progression or
unacceptable toxicity.

ARM III: Patients undergo observation only.

Patients are followed every 3 months for 1-2 years, every 6 months for 3 years, and then
annually for up to 10 years from study entry.


Inclusion Criteria:



- Histologically confirmed adenocarcinoma of the colon

- Stage II disease (pT3, pT4a-b, N0, M0)

- At least 8 lymph nodes must have been evaluated

- Meets 1 of the following criteria:

- High risk for microsatellite instability (MSI) and loss of heterozygosity (LOH)
at chromosome 18q

- Microsatellite stable (MSS) with 18q LOH

- MSI-low grade (MSI-L) with 18q LOH

- Low risk for MSI and 18q LOH

- MSS with retention of 18q alleles

- MSI-L with retention of 18q alleles

- MSI-high grade (MSI-H) with retention of 18q alleles

- MSI-H without retention of 18q alleles

- MSI-H with 18q status uninformative

- Distal extent of tumor must be ≥ 12 cm from the anal verge by endoscopy or surgical
examination

- If tumor is located beyond sigmoid colon and centimeter distance is unavailable,
include anatomic region of the colon (e.g., right colon, transverse colon,
hepatic flexure, descending colon, or cecum)

- Has undergone surgical resection of the tumor between the past 28-60 days

- Must have had a complete resection (R0 resection)

- No history of isolated, distant, or noncontiguous intra-abdominal metastases

- Patients with synchronous tumors or appendiceal tumors are ineligible

- Hereditary non-polyposis colorectal cancer allowed

- Paraffin-embedded tumor specimen (one with normal mucosa and one from the resection
tumor) available

- Performance status - ECOG 0-2

- Absolute granulocyte count ≥ 1,500/mm^3*

- Platelet count ≥ 100,000/mm^3*

- No significant bleeding unrelated to tumor within the past 6 months*

- Bilirubin normal (unless due to Gilbert's disease or similar syndrome)*

- Alkaline phosphatase (AP) < 2.5 times upper limit of normal (ULN)*

- AST < 1.5 times ULN*

- PT INR > 1.5* allowed provided the following criteria are met:

- Patient is on full-dose anticoagulants

- INR in range (usually 2-3) on a stable dose of warfarin or low molecular weight
heparin

- No active bleeding or pathological condition associated with a high risk of
bleeding unrelated to primary colon tumor

- No systemic hepatic disease*

- Creatinine ≤ 1.5 times ULN*

- Urine protein:creatinine ratio < 1.0*

- Urine protein < 1 gm on 24-hour urine collection*

- No systemic renal disease*

- History of hypertension allowed provided blood pressure < 150/90 mm Hg while on a
stable regimen of anti-hypertensive therapy*

- No New York Heart Association class III or IV cardiac disease*

- No symptomatic arrhythmia*

- No history of transient ischemic attack*

- No history of cerebrovascular accident*

- No symptomatic peripheral vascular disease*

- No arterial thromboembolic events within the past 12 months*

- No unstable angina within the past 12 months*

- No myocardial infarction within the past 12 months*

- No other systemic cardiovascular disease*

- Not pregnant or nursing*

- Negative pregnancy test*

- Fertile patients must use effective contraception during and for 3 months after
completion of study treatment*

- No active gastroduodenal ulcer by endoscopy*

- No complete obstruction or perforation of the bowel

- No history of inflammatory bowel disease

- No prior or concurrent malignancy except for nonmelanoma skin cancer, carcinoma in
situ of the cervix, breast cancer in situ, treated non-pelvic cancer from which the
patient has been disease-free for > 5 years, or history of breast cancer (without
evidence of disease) and remain on hormonal therapy for > 5 years

- No other nonmalignant systemic disease that would preclude study compliance*

- No psychiatric or addictive disorder or other condition that would preclude study
participation*

- No serious or non-healing wound, skin ulcer, or bone fracture*

- No peripheral neuropathy ≥ grade 2*

- No significant traumatic injury within the past 4 weeks*

- No known allergy to platinum compounds

- No prior radiotherapy for this cancer

- No prior systemic therapy for this cancer

- More than 28 days since prior major surgery or open biopsy*

- More than 7 days since prior core biopsy or other minor procedure except placement of
a vascular access device*

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Disease-free survival

Outcome Description:

A stratified log-rank test, with stratification on stage (IIA versus IIB) and MSI status (MSS versus MSI-L) will be used.

Outcome Time Frame:

3 years

Safety Issue:

No

Principal Investigator

Al Benson

Investigator Role:

Principal Investigator

Investigator Affiliation:

Eastern Cooperative Oncology Group

Authority:

United States: Food and Drug Administration

Study ID:

NCI-2009-00562

NCT ID:

NCT00217737

Start Date:

August 2005

Completion Date:

Related Keywords:

  • Adenocarcinoma of the Colon
  • Stage II Colon Cancer
  • Adenocarcinoma
  • Adenocarcinoma, Mucinous
  • Colonic Neoplasms

Name

Location

Albert Einstein College of MedicineBronx, New York  10461
Baylor College of MedicineHouston, Texas  77030
Howard University HospitalWashington, District of Columbia  20060
Louisiana State UniversityNew Orleans, Louisiana  70112-2282
Roswell Park Cancer InstituteBuffalo, New York  14263
Mayo ClinicRochester, Minnesota  55905
University of Iowa Hospitals and ClinicsIowa City, Iowa  52242
Washington University School of MedicineSaint Louis, Missouri  63110
Abington Memorial HospitalAbington, Pennsylvania  19001
Fox Chase Cancer CenterPhiladelphia, Pennsylvania  19111
University of Washington Medical CenterSeattle, Washington  98195-6043
Tripler Army Medical CenterHonolulu, Hawaii  96859-5000
Hurley Medical CenterFlint, Michigan  48503
University of Texas Health Science Center at San AntonioSan Antonio, Texas  78284-7811
Pennsylvania HospitalPhiladelphia, Pennsylvania  19107
Sinai Hospital of BaltimoreBaltimore, Maryland  21225
Beth Israel Deaconess Medical CenterBoston, Massachusetts  02215
Boulder Community HospitalBoulder, Colorado  80301-9019
Porter Adventist HospitalDenver, Colorado  80210
Rose Medical CenterDenver, Colorado  80220
Swedish Medical CenterEnglewood, Colorado  80110
Sky Ridge Medical CenterLone Tree, Colorado  80124
North Suburban Medical CenterThornton, Colorado  80229
Bronson Methodist HospitalKalamazoo, Michigan  49007
West Michigan Cancer CenterKalamazoo, Michigan  49007-3731
Borgess Medical CenterKalamazooaa, Michigan  49001
Fairview Ridges HospitalBurnsville, Minnesota  55337
Hutchinson Area Health CareHutchinson, Minnesota  55350
Meeker County Memorial HospitalLichfield, Minnesota  55355
United HospitalSt. Paul, Minnesota  55102
Ridgeview Medical CenterWaconia, Minnesota  55387
Abramson Cancer Center of the University of PennsylvaniaPhiladelphia, Pennsylvania  19104-4283
Avera Cancer InstituteSioux Falls, South Dakota  57105
Loyola University Medical CenterMaywood, Illinois  60153
Massachusetts General Hospital Cancer CenterBoston, Massachusetts  02114
CentraCare ClinicSaint Cloud, Minnesota  56303
Morristown Memorial HospitalMorristown, New Jersey  07962-1956
Marshfield ClinicMarshfield, Wisconsin  54449
Glendale Memorial Hospital and Health CenterGlendale, California  91204
Sutter Health Western Division Cancer Research GroupGreenbrae, California  94904
Loma Linda University Medical CenterLoma Linda, California  92354
Bridgeport HospitalBridgeport, Connecticut  06610
South Georgia Medical CenterValdosta, Georgia  31603
Ingalls Memorial HospitalHarvey, Illinois  60426
Methodist Medical Center of IllinoisPeoria, Illinois  61636
Memorial Hospital of South BendSouth Bend, Indiana  46601
Mary Bird Perkins Cancer CenterBaton Rouge, Louisiana  70809
Community Medical CenterToms River, New Jersey  08755
Beth Israel Medical CenterNew York, New York  10003
Akron General Medical CenterAkron, Ohio  44302
Lehigh Valley HospitalAllentown, Pennsylvania  18103
Delaware County Memorial HospitalDrexel Hill, Pennsylvania  19026
Reading Hospital and Medical CenterReading, Pennsylvania  19612-6052
Grand View HospitalSellersville, Pennsylvania  18960
LDS HospitalSalt Lake City, Utah  84143
Martha Jefferson HospitalCharlottesville, Virginia  22901
Waukesha Memorial HospitalWaukesha, Wisconsin  53188
Rush University Medical CenterChicago, Illinois  60612-3824
Virginia Piper Cancer InstituteMinneapolis, Minnesota  55407
University of Kansas Medical CenterKansas City, Kansas  66160-7353
Brooke Army Medical CenterFort Sam Houston, Texas  78234-6200
Hartford HospitalHartford, Connecticut  06102-5037
Franklin Square Hospital CenterBaltimore, Maryland  21237
Staten Island University HospitalStaten Island, New York  10305
Camden-Clark Memorial HospitalParkersburg, West Virginia  26102
Providence Alaska Medical CenterAnchorage, Alaska  99508
William Beaumont HospitalRoyal Oak, Michigan  48073
Cancer Institute of New JerseyNew Brunswick, New Jersey  08901
University of Nebraska Medical CenterOmaha, Nebraska  68198-3330
Broward General Medical CenterFort Lauderdale, Florida  33316
Via Christi Regional Medical CenterWichita, Kansas  67214
Ochsner Clinic FoundationNew Orleans, Louisiana  70121
Carolinas Medical CenterCharlotte, North Carolina  28232-2861
University of Oklahoma Health Sciences CenterOklahoma City, Oklahoma  73104
Scott and White Memorial HospitalTemple, Texas  76508
Northeast Alabama Regional Medical CenterAnniston, Alabama  36207
John Muir Medical CenterWalnut Creek, California  94598
Saint Anthony Medical CenterRockford, Illinois  61108
Iowa Methodist Medical CenterDes Moines, Iowa  50309
Iowa Lutheran HospitalDes Moines, Iowa  50316-2301
Weill Medical College of Cornell UniversityNew York, New York  10021
Mobile Infirmary Medical CenterMobile, Alabama  36640-0460
Group Health CooperativeSeattle, Washington  98112
University of Wisconsin Hospital and ClinicsMadison, Wisconsin  53792-0001
Great Falls ClinicGreat Falls, Montana  59405
Thompson Cancer Survival CenterKnoxville, Tennessee  37916
Overlook HospitalSummit, New Jersey  07902-0220
Winthrop University HospitalMineola, New York  11501
Cancer Institute of New Jersey at HamiltonHamilton, New Jersey  08690
MetroHealth Medical CenterCleveland, Ohio  44109
Trinity Cancer Care CenterMinot, North Dakota  58701
Mercy Fitzgerald HospitalDarby, Pennsylvania  19023
Wilford Hall Medical CenterLackland Air Force Base, Texas  78236-5300
Eisenhower Medical CenterRancho Mirage, California  92270
Montefiore Medical CenterBronx, New York  10467-2490
Saint Peter's University HospitalNew Brunswick, New Jersey  08901-1780
Warren HospitalPhillipsburg, New Jersey  08865
Lewistown HospitalLewistown, Pennsylvania  17044
Mount Nittany Medical CenterState College, Pennsylvania  16803
Sibley Memorial HospitalWashington, District of Columbia  20016
Somerset Medical CenterSomerville, New Jersey  08876
North Colorado Medical CenterGreeley, Colorado  80631
McKee Medical CenterLoveland, Colorado  80539
Siouxland Regional Cancer CenterSioux City, Iowa  51101-1733
Cancer Center of Kansas - ChanuteChanute, Kansas  66720
Cancer Center of Kansas - Dodge CityDodge City, Kansas  67801
Cancer Center of Kansas - NewtonNewton, Kansas  67114
Cancer Center of Kansas - SalinaSalina, Kansas  67042
Cancer Center of Kansas - WellingtonWellington, Kansas  67152
Associates in Womens HealthWichita, Kansas  67203
Cancer Center of Kansas - WinfieldWinfield, Kansas  67156
Holland Community HospitalHolland, Michigan  49423
Munson Medical CenterTraverse City, Michigan  49684
Northern Rockies Radiation Oncology CenterBillings, Montana  59101
Bozeman Deaconess HospitalBozeman, Montana  59715
Big Sky OncologyGreat Falls, Montana  59405
Kalispell Medical OncologyKalispell, Montana  59901
Kalispell Regional Medical CenterKalispell, Montana  59901
Eastern Montana Cancer CenterMiles City, Montana  59301
Adena Regional Medical CenterChillicothe, Ohio  54601
Grady Memorial HospitalDelaware, Ohio  43015
Fairfield Medical CenterLancaster, Ohio  43130
Avera McKennan Hospital and University Health CenterSioux Falls, South Dakota  57105
Medical X-Ray CenterSioux Falls, South Dakota  57105
American Fork HospitalAmerican Fork, Utah  84003
Logan Regional HospitalLogan, Utah  84321
Cottonwood Hospital Medical CenterMurray, Utah  84107
McKay-Dee Hospital CenterOgden, Utah  84403
Cancer Care Northwest - Spokane SouthSpokane, Washington  99202
Welch Cancer CenterSheridan, Wyoming  82801
Methodist Estabrook Cancer CenterOmaha, Nebraska  68114-4199
Cancer Centers of the CarolinasGreenville, South Carolina  29605
City of Hope Medical CenterDuarte, California  91010
Paoli Memorial HospitalPaoli, Pennsylvania  19301-1792
Elkhart General HospitalElkhart, Indiana  46515
South Bend ClinicSouth Bend, Indiana  46617
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical CenterColumbus, Ohio  43210-1240
Parkland Memorial HospitalDallas, Texas  75235
Rochester General HospitalRochester, New York  14621
Front Range Cancer SpecialistsFort Collins, Colorado  80528
University Medical Center of Southern NevadaLas Vegas, Nevada  89102
Finger Lakes Hematology and OncologyClifton Springs, New York  14432
Jennersville Regional HospitalWest Grove, Pennsylvania  19390-9499
Saint Rose HospitalHayward, California  94545
Alta Bates Summit Medical Center - Summit CampusOakland, California  94609
Sutter Solano Medical CenterVallejo, California  94589
Poudre Valley HospitalFort Collins, Colorado  80524
Beebe Medical CenterLewes, Delaware  19958
Saint Joseph's Hospital of AtlantaAtlanta, Georgia  30342-1701
Piedmont HospitalAtlanta, Georgia  30309
Gwinnett Medical CenterLawrenceville, Georgia  30045
Southern Regional Medical CenterRiverdale, Georgia  30274-2600
Memorial HospitalCarthage, Illinois  62321
Swedish Covenant HospitalChicago, Illinois  60625
Mercy Hospital and Medical CenterChicago, Illinois  60616
Hematology and Oncology AssociatesChicago, Illinois  60611
Galesburg Cottage HospitalGalesburg, Illinois  61401
Galesburg ClinicGalesburg, Illinois  61401
Mason District HospitalHavana, Illinois  62644
Kewanee HospitalKewanee, Illinois  61443
McDonough District HospitalMacomb, Illinois  61455
BroMenn Regional Medical CenterNormal, Illinois  61761
Proctor HospitalPeoria, Illinois  61614
Perry Memorial HospitalPrinceton, Illinois  61356
Genesis Medical Center - West CampusDavenport, Iowa  52804
Bay Regional Medical CenterBay City, Michigan  48708
Mecosta County Medical CenterBig Rapids, Michigan  49307
Community Cancer Center of MonroeMonroe, Michigan  48162
Saint Francis Medical CenterCape Girardeau, Missouri  63701
Creighton University Medical CenterOmaha, Nebraska  68131-2197
Wayne Radiation OncologyGoldsboro, North Carolina  27534
Wilson Medical CenterWilson, North Carolina  27893-3428
Bismarck Cancer CenterBismarck, North Dakota  58501
Grandview HospitalDayton, Ohio  45405
Fremont Memorial HospitalFremont, Ohio  43420
Lima Memorial HospitalLima, Ohio  45804
Firelands Regional Medical CenterSandusky, Ohio  44870
Mercy Medical CenterSpringfield, Ohio  45504
Mercy Hospital of TiffinTiffin, Ohio  44883
Fulton County Health CenterWauseon, Ohio  43567
Providence Milwaukie HospitalMilwaukie, Oregon  97222
Bryn Mawr HospitalBryn Mawr, Pennsylvania  19010
Doctor's Hospital of LaredoLaredo, Texas  78041
Danville Regional Medical CenterDanville, Virginia  24541
North Star Lodge Cancer Center at Yakima Valley Memorial HospitalYakima, Washington  98902
Denver Health Medical CenterDenver, Colorado  80204-4507
Exempla Lutheran Medical CenterWheat Ridge, Colorado  80033
Eureka HospitalEureka, Illinois  61530
Mercy HospitalCoon Rapids, Minnesota  55433
Capital Medical CenterOlympia, Washington  98502
Allenmore HospitalTacoma, Washington  98411-0414
Graham Hospital AssociationCanton, Illinois  61520
Holy Family Medical CenterDes Plaines, Illinois  60016
Saint Joseph Medical CenterJoliet, Illinois  60435
Pekin HospitalPekin, Illinois  61554
Medical Oncology and Hematology AssociatesDes Moines, Iowa  50309
Ottumwa Regional Health CenterOttumwa, Iowa  52501
Anne Arundel Medical CenterAnnapolis, Maryland  21401
Bixby Medical CenterAdrian, Michigan  49221
Saint Joseph Mercy HospitalAnn Arbor, Michigan  48106
Fairview-Southdale HospitalEdina, Minnesota  55435
Abbott-Northwestern HospitalMinneapolis, Minnesota  55407
Regions HospitalSaint Paul, Minnesota  55101
Saint Francis Regional Medical CenterShakopee, Minnesota  55379
Rice Memorial HospitalWillmar, Minnesota  56201
Mary Imogene Bassett HospitalCooperstown, New York  13326
Altru Cancer CenterGrand Forks, North Dakota  58206
Saint Luke's HospitalMaumee, Ohio  43537
Lancaster General HospitalLancaster, Pennsylvania  17604-3555
Highland General HospitalOakland, California  94602
Northeast Georgia Medical CenterGainesville, Georgia  30501
Swedish American HospitalRockford, Illinois  61104
Saint Luke's HospitalChesterfield, Missouri  63017
Missouri Cancer AssociatesColumbia, Missouri  65201
Center for Cancer Care and ResearchSt. Louis, Missouri  63141
Randolph HospitalAsheboro, North Carolina  27203
Miami Valley HospitalDayton, Ohio  45409
Allegheny Cancer Center at Allegheny General HospitalPittsburgh, Pennsylvania  15212
Spartanburg Regional Medical CenterSpartanburg, South Carolina  29303
Eastern Connecticut Hematology and Oncology AssociatesNorwich, Connecticut  06360
Cancer Center of Kansas - Fort ScottFort Scott, Kansas  66701
Cancer Center of Kansas-IndependenceIndependence, Kansas  67301
Lawrence Memorial HospitalLawrence, Kansas  66044
Bozeman Deaconess Cancer CenterBozeman, Montana  59715
Northern Montana HospitalHavre, Montana  59501
Mary Rutan HospitalBellefontaine, Ohio  43311
Wayne HospitalGreenville, Ohio  45331
Knox Community HospitalMount Vernon, Ohio  43050
Fisher-Titus Medical CenterNorwalk, Ohio  44857
Clinton Memorial HospitalWilmington, Ohio  45177
Adventist Medical CenterPortland, Oregon  97216
Providence Centralia HospitalCentralia, Washington  98531-9027
Wenatchee Valley Medical CenterWenatchee, Washington  98801-2028
Marshfield Clinic Cancer Care at Regional Cancer CenterEau Claire, Wisconsin  54701
UW Cancer Center Johnson CreekJohnson Creek, Wisconsin  53038
Saint Joseph's HospitalMarshfield, Wisconsin  54449
Marshfield Clinic - Weston CenterWeston, Wisconsin  54476
Marshfield Clinic - Wisconsin Rapids CenterWisconsin Rapids, Wisconsin  54494
Rocky Mountain OncologyCasper, Wyoming  82609
Longmont United HospitalLongmont, Colorado  80501
Lincoln Medical and Mental Health CenterBronx, New York  10451
Baton Rouge General Medical CenterBaton Rouge, Louisiana  70821-2511
Singing River HospitalPascagoula, Mississippi  39581
Zale Lipshy University HospitalDallas, Texas  75235-7786
Ben Taub General HospitalHouston, Texas  77030
Methodist HospitalHouston, Texas  77030
Sharp Memorial HospitalSan Diego, California  92123
Greene Memorial HospitalXenia, Ohio  45385
Easton HospitalEaston, Pennsylvania  18042
Greater Baltimore Medical CenterBaltimore, Maryland  21204
Rutherford HospitalRutherfordton, North Carolina  28139
Union Hospital of Cecil CountyElkton MD, Maryland  21921
Cancer Centers of the Carolinas - Grove CommonsGreenville, South Carolina  29605
Cancer Centers of the Carolinas - SenecaSeneca, South Carolina  29672
Cancer Centers of the Carolinas - SpartanburgSpartanburg, South Carolina  29307
Presbyterian HospitalCharlotte, North Carolina  28233-3549
Mayo Clinic in ArizonaScottsdale, Arizona  85259-5404
Mayo Clinic in FloridaJacksonville, Florida  32224
Sherman HospitalElgin, Illinois  60120-2198
Memorial Medical CenterSpringfield, Illinois  62781
Lapeer Regional HospitalLapeer, Michigan  48446
Saint Francis Medical CenterGrand Island, Nebraska  68802
Southeastern Medical Oncology CenterGoldsboro, North Carolina  27534
Doylestown HospitalDoylestown, Pennsylvania  18901
Wellmont Holston Valley Hospital and Medical CenterKingsport, Tennessee  37662
La Grange Memorial HospitalLa Grange, Illinois  60525
Metro Health HospitalGrand Rapids, Michigan  49506
Guardian Oncology and Center for WellnessMissoula, Montana  59804
Queen's Medical CenterHonolulu, Hawaii  96813
University of VirginiaCharlottesville, Virginia  22908
University of PittsburghPittsburgh, Pennsylvania  15261
Woodwinds Health CampusWoodbury, Minnesota  55125
University of Alabama at BirminghamBirmingham, Alabama  35294-3300
Providence HospitalMobile, Alabama  36608
Vanderbilt UniversityNashville, Tennessee  37232-6305
University of North CarolinaChapel Hill, North Carolina  27599
Duke University Medical CenterDurham, North Carolina  27710
Meharry Medical CollegeNashville, Tennessee  37208-3599
Lynchburg Hematology-Oncology ClinicLynchburg, Virginia  24501
Northwestern UniversityChicago, Illinois  60611
Cancer Care AssociatesTulsa, Oklahoma  74136
East Bay Radiation Oncology CenterCastro Valley, California  94546
Contra Costa Regional Medical CenterMartinez, California  94553-3156
Memorial Medical CenterModesto, California  95355
Larry G Strieff MD Medical CorporationOakland, California  94609
Tahoe Forest Cancer CenterTruckee, California  96161
Kapiolani Medical Center at Pali MomiAiea, Hawaii  96701
Kapiolani Medical Center for Women and ChildrenHonolulu, Hawaii  96826
Maui Memorial Medical CenterWailuku, Hawaii  96793
Elmhurst Memorial HospitalElmhurst, Illinois  60126
Bay Area HospitalCoos Bay, Oregon  97420
Hennepin County Medical CenterMinneapolis, Minnesota  
VA Palo Alto Health Care SystemPalo Alto, California  94304-1207
Saint Louis University HospitalSt. Louis, Missouri  63110-0250
University of RochesterRochester, New York  14642
Saints Memorial Medical CenterLowell, Massachusetts  01852
Holy Cross HospitalFort Lauderdale, Florida  33308
El Camino HospitalMountain View, California  94040
Cleveland Clinic Florida - WestonWeston, Florida  33331
University of California at San DiegoLa Jolla, California  92093
Case Western Reserve UniversityCleveland, Ohio  44106
Emory UniversityAtlanta, Georgia  30322
Wayne State UniversityDetroit, Michigan  48202
New Hampshire Oncology-Hematology PAHooksett, New Hampshire  03106
Albert Einstein Medical CenterPhiladelphia, Pennsylvania  19141
Straub Clinic and HospitalHonolulu, Hawaii  96813
University of Massachusetts Medical SchoolWorcester, Massachusetts  01605
Riverside Methodist HospitalColumbus, Ohio  43214
Licking Memorial HospitalNewark, Ohio  43055-2899
Providence Portland Medical CenterPortland, Oregon  97213-3635
California Pacific Medical CenterSan Francisco, California  94115
Mid Dakota ClinicBismarck, North Dakota  58501
Columbus CCOPColumbus, Ohio  43206
Indiana University Medical CenterIndianapolis, Indiana  46202
Weiss Memorial HospitalChicago,, Illinois  60640
Nyack HospitalNyack, New York  10960
Presbyterian - Saint Lukes Medical Center - Health OneDenver, Colorado  80218
Kaiser PermanenteSacramento, California  
University of Texas Southwestern Medical CenterDallas, Texas  
Wichita CCOPWichita, Kansas  67214-3882
Montana Cancer Consortium CCOPBillings, Montana  59101
Alegent Health Immanuel Medical CenterOmaha, Nebraska  68122
Alegent Health Bergan Mercy Medical CenterOmaha, Nebraska  68124
Flower HospitalSylvania, Ohio  43560-2197
Huntsman Cancer Institute/University of UtahSalt Lake City, Utah  84112
Mount Sinai Hospital Medical CenterChicago, Illinois  60608
Southeastern Regional Medical CenterLumberton, North Carolina  28359
Granville Medical CenterOxford, North Carolina  27565
Person Memorial HospitalRoxboro, North Carolina  27573
Metro-Minnesota CCOPSt. Louis Park, Minnesota  
UC Davis Comprehensive Cancer CenterSacramento, California  95817
Providence HospitalSouthfield, Michigan  48075
Lagrange Oncology AssociatesLa Grange, Illinois  60525
Cancer Centers of the Carolinas - EasleyEasley, South Carolina  29640
Thomas Jefferson University HospitalPhiladelphia, Pennsylvania  19131
Decatur Memorial HospitalDecatur, Illinois  62526
Louisiana State University Health Science CenterNew Orleans, Louisiana  70112
Frederick Memorial HospitalFrederick, Maryland  21701
Lankenau HospitalWynnewood, Pennsylvania  19096
Princeton Community HospitalPrinceton, West Virginia  24740
Montana Cancer SpecialistsMissoula, Montana  59807-7877
Desert Regional Medical CenterPalm Springs, California  92262
Florida HospitalOrlando, Florida  32803
Memorial Health University Medical CenterSavannah, Georgia  31404
University of Chicago Comprehensive Cancer CenterChicago, Illinois  60637-1470
M D Anderson Cancer CenterHouston, Texas  77030
University of Southern CaliforniaLos Angeles, California  90033
Veterans Administration Center-SeattleSeattle, Washington  98108
DeKalb Medical CenterDecatur, Georgia  30033
Northern Indiana Cancer Research ConsortiumSouth Bend, Indiana  
Rockwood ClinicSpokane, Washington  99220
Clearview Cancer InstituteHuntsville, Alabama  35805
Hawaii Medical Center EastHonolulu, Hawaii  96817
Norwalk HospitalNorwalk, Connecticut  06856
Penn State Milton S Hershey Medical CenterHershey, Pennsylvania  17033
Valley View Hospital Cancer CenterGlenwood Springs, Colorado  81601
Hays Medical CenterHays, Kansas  67601
North Broward Medical CenterDearfield Beach, Florida  33064-3596
Wake Forest University Health SciencesWinston-Salem, North Carolina  27157
OSF Saint Francis Medical CenterPeoria, Illinois  61637
Northside HospitalAtlanta, Georgia  30342
Saint Edward Mercy Medical CenterFt. Smith, Arkansas  72903
Mills - Peninsula HospitalsBurlingame, California  94010
Valley Medical Oncology Consultants-Castro ValleyCastro Valley, California  94546
Eden Hospital Medical CenterCastro Valley, California  94546
Northbay Cancer CenterFairfield, California  94533
Valley Medical Oncology Consultants-FremontFremont, California  94538
Fremont - Rideout Cancer CenterMarysville, California  95901
Palo Alto Medical Foundation-Camino DivisionMountain View, California  94040
Bay Area Breast Surgeons IncOakland, California  94609
Bay Area Tumor Institution CCOPOakland, California  94609
Tom K Lee IncOakland, California  94609
Saint Joseph HospitalOrange, California  92868
Palo Alto Medical Foundation Heath CarePalo Alto, California  94301
Valley Medical Oncology ConsultantsPleasanton, California  94588
Valley Care Health System - PleasantonPleasanton, California  94588
University of California San Francisco Medical Center-Mount ZionSan Francisco, California  94115
Doctors Medical Center- JC Robinson Regional Cancer CenterSan Pablo, California  94806
Santa Rosa Memorial HospitalSana Rosa, California  95405
The Medical Center of AuroraAurora, Colorado  80012
Penrose-Saint Francis HealthcareColorado Springs, Colorado  80907
Memorial Hospital Colorado SpringsColorado Springs, Colorado  80909
Saint Anthony Central HospitalDenver, Colorado  80204
Exempla Saint Joseph HospitalDenver, Colorado  80218
Colorado Cancer Research Program CCOPDenver, Colorado  80224-2522
Saint Mary's Hospital and Regional Medical CenterGrand Junction, Colorado  81502
Saint Mary Corwin Medical CenterPueblo, Colorado  81004
Danbury HospitalDanbury, Connecticut  06810
Saint Francis Hospital and Medical CenterHartford, Connecticut  06105
The Hospital of Central ConnecticutNew Britain, Connecticut  06050
Stamford HospitalStamford, Connecticut  06904
Bayhealth Medical Center at Kent GeneralDover, Delaware  19901
Edna Williams Cancer Center at the Baptist Cancer InstituteJacksonville, Florida  32207
Cancer Centers of Central Florida PALeesburg, Florida  34788
Phoebe Putney Memorial HospitalAlbany, Georgia  31703
Atlanta Regional CCOPAtlanta, Georgia  30342
Well Star Cobb HospitalAustell, Georgia  30106
John B Amos Cancer CenterColumbus, Georgia  31904
Veterans Administration Medical CenterDecatur, Georgia  30033
Wellstar Kennestone HospitalMarietta, Georgia  30060
Saint Joseph's-Candler Health SystemSavannah, Georgia  31405
Oncare Hawaii Inc-POB IIHonolulu, Hawaii  96813
Oncare Hawaii Inc-KuakiniHonolulu, Hawaii  96817
University of HawaiiHonolulu, Hawaii  96813
Pacific Cancer Institute of MauiWailuku, Hawaii  96793
Saint Luke's Mountain States Tumor InstituteBoise, Idaho  83712
Saint Anthony's HealthAlton, Illinois  62002
Rush - Copley Medical CenterAurora, Illinois  60504
John H Stroger Jr Hospital of Cook CountyChicago, Illinois  60612-3785
Saint Francis HospitalEvanston, Illinois  60202
Evanston CCOP-NorthShore University HealthSystemEvanston, Illinois  60201
Hopedale Medical Complex - HospitalHopedale, Illinois  61747
Joliet Oncology-Hematology Associates LimitedJoliet, Illinois  60435
Midwest Center for Hematology OncologyJoliet, Illinois  60432
Provena Saint Mary's HospitalKankakee, Illinois  60901
North Shore Hematology OncologyLibertyville, Illinois  60048
Vigliotti, Antonio, P.G. M.D. (UIA Investigator)Moline, Illinois  61265
Stoffel, Thomas J MD (UIA Investigator)Moline, Illinois  61265
Garneau, Stewart C MD (UIA Investigator)Moline, Illinois  61265
Sharis, Christine M MD (UIA Investigator)Moline, Illinois  61265
Porubcin, Michael MD (UIA Investigator)Moline, Illinois  61265
Good Samaritan Regional Medical CenterMt. Vernon, Illinois  62864
Hematology Oncology Consultants LimitedNaperville, Illinois  60540
Community Cancer Center FoundationNormal, Illinois  61761
Illinois CancerCare-Ottawa ClinicOttawa, Illinois  61350
Ottawa Regional Hospital and Healthcare CenterOttawa, Illinois  61350
Pekin Cancer Treatment CenterPekin, Illinois  61554
Illinois Oncology Research Association CCOPPeoria, Illinois  61615
Illinois CancerCare-PeoriaPeoria, Illinois  61615
Illinois Valley HospitalPeru, Illinois  61354
Hematology Oncology Associates of Illinois - SkokieSkokie, Illinois  60076
Midwest Cancer Research Group IncorporatedSkokie, Illinois  60077
Edward H Kaplan MD and AssociatesSkokie, Illinois  60076
Saint Margaret's HospitalSpring Valley, Illinois  61362
Carle Clinic-Urbana MainUrbana, Illinois  61801
Saint Francis Hospital and Health CentersBeech Grove, Indiana  46107
Fort Wayne Medical Oncology and Hematology Inc - State BoulevardFort Wayne, Indiana  46845
Wishard HospitalIndianapolis, Indiana  46202
Saint Anthony Memorial Health CenterMichigan City, Indiana  46360
Reid Hospital and Health Care ServicesRichmond, Indiana  47374
McFarland ClinicAmes, Iowa  50010
Hematology Oncology Associates-Quad CitiesBettendorf, Iowa  52722
Constantinou, Costas L MD (UIA Investigator)Bettendorf, Iowa  52722
Cedar Rapids Oncology AssociationCedar Rapids, Iowa  52403
Mercy HospitalCedar Rapids, Iowa  52403
Medical Oncology and Hematology Associates-West Des MoinesClive, Iowa  50325
Genesis Medical Center - East CampusDavenport, Iowa  52803
Iowa Oncology Research Association CCOPDes Moines, Iowa  50309
Mercy CapitolDes Moines, Iowa  50307
Mercy Medical Center - Des MoinesDes Moines, Iowa  50314
Medical Oncology and Hematology Associates-Des MoinesDes Moines, Iowa  50309
Mercy Medical Center - North IowaMason City, Iowa  50401
Mercy Medical Center-Sioux CitySioux City, Iowa  51104
Saint Luke's Regional Medical CenterSioux City, Iowa  51104
Cancer Center of Kansas - El DoradoEl Dorado, Kansas  67042
Cancer Center of Kansas-KingmanKingman, Kansas  67068
Cancer Center of Kansas - ParsonsParsons, Kansas  67357
Cancer Center of Kansas - PrattPratt, Kansas  67124
Stormont-Vail Regional Health CenterTopeka, Kansas  66604
Saint Francis Hospital and Medical Center - TopekaTopeka, Kansas  66606
Cancer Center of Kansas-Wichita Medical Arts TowerWichita, Kansas  67208
Cancer Center of Kansas - Main OfficeWichita, Kansas  67214
Our Lady Bellefonte HospitalAshland, Kentucky  41101
Ochsner Clinic Foundation-Baton RougeBaton Rouge, Louisiana  70809
DeSoto Regional Health SystemMansfield, Louisiana  71052
Louisiana State University Sciences Center- MonroeMonroe, Louisiana  71210
Medical Center of LouisianaNew Orleans, Louisiana  70112
Highland ClinicShreveport, Louisiana  71105
Lawrence MemorialMedford, Massachusetts  02155
Holy Family HospitalMethuen, Massachusetts  01844
Norwood HospitalNorwood, Massachusetts  02062
Commonwealth Hematology Oncology PC-QuincyQuincy, Massachusetts  02169
Hickman Cancer CenterAdrian, Michigan  49221
Michigan Cancer Research Consortium Community Clinical Oncology ProgramAnn Arbor, Michigan  48106
Oakwood HospitalDearborn, Michigan  48123
Saint John Hospital and Medical CenterDetroit, Michigan  48236
Michigan State University - Breslin Cancer CenterEast Lansing, Michigan  48824-1313
Green Bay Oncology - EscanabaEscanaba, Michigan  49431
McLaren Regional Medical CenterFlint, Michigan  48532
Grand Rapids Clinical Oncology ProgramGrand Rapids, Michigan  49503
Saint Mary's Health CareGrand Rapids, Michigan  49503
Spectrum Health at Butterworth CampusGrand Rapids, Michigan  49503
Green Bay Oncology - Iron MountainIron Mountain, Michigan  49801
Allegiance HealthJackson, Michigan  49201
Ingham Regional Medical CenterLansing, Michigan  48910
Sparrow HospitalLansing, Michigan  48912
Saint Mary Mercy HospitalLivonia, Michigan  48154
Mercy Memorial HospitalMonroe, Michigan  48162
Mercy Health Partners-Mercy CampusMuskegon, Michigan  49443
Mercy Health Partners-Hackley CampusMuskegon, Michigan  49442
Saint Joseph Mercy OaklandPontiac, Michigan  48341-2985
Saint Joseph Mercy Port HuronPort Huron, Michigan  48060
Saint Mary's of MichiganSaginaw, Michigan  48601
Lakeland HospitalSt. Joseph, Michigan  49085
Saint John Macomb-Oakland HospitalWarren, Michigan  48093
Medini, Eitan MD (UIA Investigator)Alexandria, Minnesota  56308
Miller-Dwan HospitalDuluth, Minnesota  55805
Saint Luke's Hospital of DuluthDuluth, Minnesota  55805
Etzell, Paul S MD (UIA Investigator)Fergus Falls, Minnesota  56537
Swenson, Wade II, MD (UIA Investigator)Fergus Falls, Minnesota  56537
Unity HospitalFridley, Minnesota  55432
Immanuel-Saint Joseph Hospital-Mayo Health SystemMankato, Minnesota  56002
Saint John's Hospital - HealtheastMaplewood, Minnesota  55109
Minnesota Oncology Hematology PA-MaplewoodMaplewood, Minnesota  55109
Minneapolis Veterans Medical CenterMinneapolis, Minnesota  55417
North Memorial Medical Health CenterRobbinsdale, Minnesota  55422
Saint Cloud HospitalSaint Cloud, Minnesota  56303
Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, Minnesota  55416
Saint Joseph's Hospital - HealtheastSaint Paul, Minnesota  55102
Minnesota Oncology and Hematology PA-WoodburyWoodbury, Minnesota  55125
Southeast Missouri HospitalCape Girardeau, Missouri  63701
Freeman Health SystemJoplin, Missouri  64804
Saint Anthony's Medical CenterSaint Louis, Missouri  63128
Saint Louis-Cape Girardeau CCOPSaint Louis, Missouri  63141
Missouri Baptist Medical CenterSaint Louis, Missouri  63131
Saint John's Mercy Medical CenterSaint Louis, Missouri  63141
Ozark Health Ventures LLC dba Cancer Research for The Ozarks SpringfieldSpringfield, Missouri  65802
Saint John's HospitalSpringfield, Missouri  65804
Cox Medical CenterSpringfield, Missouri  65807
Hematology-Oncology Centers of the Northern Rockies PCBillings, Montana  59101
Saint Vincent HealthcareBillings, Montana  59101
Deaconess Medical CenterBillings, Montana  59107
Billings ClinicBillings, Montana  59107-7000
Internal Medicine of BozemanBozeman, Montana  59715
Saint James Community Hospital and Cancer Treatment CenterButte, Montana  59701
Benefis Healthcare- Sletten Cancer InstituteGreat Falls, Montana  59405
Berdeaux, Donald MD (UIA Investigator)Great Falls, Montana  59405
Saint Peter's Community HospitalHelena, Montana  59601
Glacier Oncology PLLCKalispell, Montana  59901
Community Medical HospitalMissoula, Montana  59801
Saint Patrick Hospital - Community HospitalMissoula, Montana  59802
Good Samaritan HospitalKearney, Nebraska  68847
Lincoln Medical Education Foundation Cancer Resource CenterLincoln, Nebraska  68510
Missouri Valley Cancer Consortium CCOPOmaha, Nebraska  68106
Nevada Cancer Research Foundation CCOPLas Vegas, Nevada  89106
New Hampshire Oncology Hematology AssociatesHooksett, New Hampshire  03106
LRGHealthcare-Lakes Region General HospitalLaconia, New Hampshire  03246
Elliot HospitalManchester, New Hampshire  03103
Portsmouth Regional HospitalPortsmouth, New Hampshire  03802
Ocean Medical CenterBrick, New Jersey  08724
Cooper Hospital University Medical CenterCamden, New Jersey  08103
Veterans Adminstration New Jersey Health Care SystemEast Orange, New Jersey  07018-1095
Hunterdon Medical CenterFlemington, New Jersey  08822
Saint Barnabas Medical CenterLivingston, New Jersey  07039
Mountainside HospitalMontclair, New Jersey  07042
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington CountyMount Holly, New Jersey  08060
Sparta Cancer Treatment CenterSparta, New Jersey  07871
South Jersey HealthcareVineland, New Jersey  08360
Virtua West Jersey Hospital VoorheesVoorhees, New Jersey  08043
The North Division of Montefiore Medical CenterBronx, New York  10466
Veterans Affairs Western New York Health Care System-BuffaloBuffalo, New York  14215
Orange Regional Medical CenterMiddletown, New York  10940
New York University Langone Medical CenterNew York, New York  10016
Saint Luke's Roosevelt Hospital Center - Saint Luke's DivisionNew York, New York  10025
Interlakes Foundation Inc-RochesterRochester, New York  14623
State University of New York Upstate Medical UniversitySyracuse, New York  13210
Faxton-Saint Luke's HealthcareUtica, New York  13502
Mission Hospitals IncAsheville, North Carolina  28801
Alamance Regional Medical CenterBurlington, North Carolina  27216
Wayne Memorial HospitalGoldsboro, North Carolina  27534
Kinston Medical Specialists PAKinston, North Carolina  28501
Saint Alexius Medical CenterBismarck, North Dakota  58501
Summa Barberton HospitalBarberton, Ohio  44203
Aultman Health FoundationCanton, Ohio  44710
Doctors HospitalColumbus, Ohio  43228
Grant Medical CenterColumbus, Ohio  43215
Mount Carmel Health Center WestColumbus, Ohio  43222
Good Samaritan Hospital - DaytonDayton, Ohio  45406
Dayton CCOPDayton, Ohio  45429
Samaritan North Health CenterDayton, Ohio  45415
Veteran Affairs Medical CenterDayton, Ohio  45428
Hematology Oncology Center IncorporatedElyria, Ohio  44035
Blanchard Valley HospitalFindlay, Ohio  45840
Atrium Medical Center-Middletown Regional HospitalFranklin, Ohio  45005-1066
Cleveland Clinic Cancer Center IndependenceIndependence, Ohio  44131
Cole, Sharon, K. M.D. (UIA Investigator)Kenton, Ohio  43326
Kettering Medical CenterKettering, Ohio  45429
Mansfield General Hospital-MedCentral Health SystemMansfield, Ohio  44903
Marietta Memorial HospitalMarietta, Ohio  45750
Toledo Radiation Oncology at Northwest Ohio Onocolgy CenterMaumee, Ohio  43537
Saint Charles HospitalOregon, Ohio  43616
North Coast Cancer CareSandusky, Ohio  44870
Toledo Community Hospital Oncology Program CCOPToledo, Ohio  43617
Mercy Cancer Center at Saint Anne Mercy HospitalToledo, Ohio  43623
University of ToledoToledo, Ohio  43614
Saint Vincent Mercy Medical CenterToledo, Ohio  43608
Upper Valley Medical CenterTroy, Ohio  45373
Saint Ann's HospitalWesterville, Ohio  43081
Cleveland Clinic Wooster Specialty CenterWooster, Ohio  44691
Wright-Patterson Medical CenterWright-Patterson Afb, Ohio  45433-5529
Genesis HealthCare SystemZanesville, Ohio  43701
Natalie W Bryant Cancer CenterTulsa, Oklahoma  74136
Providence Saint Vincent Medical CenterPortland, Oregon  97225
Columbia River Oncology ProgramPortland, Oregon  97225
Salem HospitalSalem, Oregon  97309
Saint Luke's HospitalBethlehem, Pennsylvania  18015
Pocono Medical CenterEast Stroudsburg, Pennsylvania  18301
Ephrata Cancer CenterEphrata, Pennsylvania  17522
Riddle HospitalMedia, Pennsylvania  19063
Pottstown Memorial Medical CenterPottstown, Pennsylvania  19464
Hematology and Oncology Associates of North East PennsylvaniaScranton, Pennsylvania  18508
Scranton Hematology OncologyScranton, Pennsylvania  18510
Mercy HospitalScranton, Pennsylvania  18501
Associates In Hematology Oncology PC-UplandUpland, Pennsylvania  19013
Mainline Health CCOPWynnewood, Pennsylvania  19096
Hematology and Oncology Associates of Rhode Island IncCranston, Rhode Island  02920
Kent County HospitalWarwick, Rhode Island  02886
AnMed Health HospitalAnderson, South Carolina  29621
Greenville CCOPGreenville, South Carolina  29615
Greenville Memorial HospitalGreenville, South Carolina  29605
Upstate Carolina CCOPSpartanburg, South Carolina  29303
Sanford Cancer Center-Oncology ClinicSioux Falls, South Dakota  57104
The Don and Sybil Harrington Cancer CenterAmarillo, Texas  79106
Veterans Administration Medical CenterHouston, Texas  77030
Saint Luke's Episcopal HospitalHouston, Texas  77030
Cancer Therapy and Research Center at The UT Health Science Center at San AntonioSan Antonio, Texas  78229
Audie L Murphy Veterans Affairs HospitalSan Antonio, Texas  78209
University HospitalSan Antonio, Texas  78229
Southwestern Oncology Research DepartmentBennington, Vermont  05201
Fredericksburg Oncology IncFredericksburg, Virginia  22401
Southwest VA Regional Cancer CenterNorton, Virginia  24273
Auburn Regional Medical CenterAuburn, Washington  98002
Harrison Bremerton Hematology and OncologyBremerton, Washington  98310
Saint Francis HospitalFederal Way, Washington  98003
Columbia Basin Hematology and Oncology PLLCKennewick, Washington  99336
Providence - Saint Peter HospitalOlympia, Washington  98506-5166
Good Samaritan Community HospitalPuyallup, Washington  98372
Minor and James Medical PLLCSeattle, Washington  98104
The PolyclinicSeattle, Washington  98122
Swedish Medical Center-First HillSeattle, Washington  98122-4307
Northwest CCOPTacoma, Washington  98405
Multicare Health SystemTacoma, Washington  98415
Saint Clare HospitalTacoma, Washington  98499
Saint Joseph Medical CenterTacoma, Washington  98405
Edwards Comprehensive Cancer CenterHuntington, West Virginia  25701
West Virginia UniversityMorgantown, West Virginia  26506
Sacred Heart HospitalEau Claire, Wisconsin  54701
Central Wisconsin Cancer ProgramFond Du Lac, Wisconsin  54935
Saint Vincent HospitalGreen Bay, Wisconsin  54301
Green Bay Oncology Limited at Saint Mary's HospitalGreen Bay, Wisconsin  54303
Saint Mary's HospitalGreen Bay, Wisconsin  54303
Green Bay Oncology at Saint Vincent HospitalGreen Bay, Wisconsin  54301-3526
Aurora BayCare Medical CenterGreen Bay, Wisconsin  54311-6519
Dean Hematology and Oncology ClinicMadison, Wisconsin  53717
UW Health Oncology - 1 South ParkMadison, Wisconsin  53715
Vince Lombardi Cancer Clinic-MarinetteMarinette, Wisconsin  54143
Bay Area Medical CenterMarinette, Wisconsin  54143
Marshfield Clinic-Minocqua CenterMinocqua, Wisconsin  54548
Oconomowoc Memorial Hospital-ProHealth Care IncOconomowoc, Wisconsin  53066-3896
Green Bay Oncology - Oconto FallsOconto Falls, Wisconsin  54154
Marshfield Clinic at James Beck Cancer CenterRhinelander, Wisconsin  54501
Marshfield Clinic-Rice Lake CenterRice Lake, Wisconsin  54868
Saint Michael's HospitalStevens Point, Wisconsin  54481
Green Bay Oncology - Sturgeon BaySturgeon Bay, Wisconsin  54235
Marshfield Clinic-Wausau CenterWausau, Wisconsin  54401
Aspirus Regional Cancer CenterWausau, Wisconsin  54401
Olathe Cancer CenterOlathe, Kansas  66061
Jupiter Medical CenterJupiter, Florida  33458
University of IllinoisChicago, Illinois  60612
Hamot Medical CenterErie, Pennsylvania  16550
York HospitalYork, Maine  03909
Elkhart ClinicElkhart, Indiana  46515
John Muir Medical Center-Concord CampusConcord, California  94520
Washington HospitalFremont, California  94538
Saint Jude Medical CenterFullerton, California  92835
Marin General HospitalGreenbrae, California  94904
Veterans Affairs Loma Linda Healthcare SystemLoma Linda, California  92357
University of Colorado Cancer Center - Anschutz Cancer PavilionAurora, Colorado  80045
Denver Veterans Administration Medical CenterDenver, Colorado  80220
The Shaw Regional Cancer CenterEdwards, Colorado  81632
Montrose Memorial HospitalMontrose, Colorado  81401
Memorial Healthcare System - Joe DiMaggio Children's HospitalHollywood, Florida  33021
Mount Sinai Medical Center CCOPMiami Beach, Florida  33140
Northeast Georgia Cancer Care LLCAthens, Georgia  30607
Harbin Clinic Medical Oncology and Clinical ResearchRome, Georgia  30165
Portneuf Medical CenterPocatello, Idaho  83201
Kootenai Cancer CenterPost Falls, Idaho  83854
Illinois CancerCare-BloomingtonBloomington%, Illinois  61701
Illinois CancerCare-CantonCanton, Illinois  61520
Illinois CancerCare-CarthageCarthage, Illinois  62321
Jesse Brown Veterans Affairs Medical CenterChicago, Illinois  60612
Illinois CancerCare-EurekaEureka, Illinois  61530
Illinois CancerCare-CottageGalesburg, Illinois  61401
Delnor Community HospitalGeneva, Illinois  60134
Illinois CancerCare-HavanaHavana, Illinois  62644
Illinois CancerCare-Kewanee ClinicKewanee, Illinois  61443
Illinois CancerCare-MacombMacomb, Illinois  61455
Illinois CancerCare-MonmouthMonmouth, Illinois  61462
DuPage Medical Group-OgdenNaperville, Illinois  60563
Illinois CancerCare-Community Cancer CenterNormal, Illinois  61761
Illinois CancerCare-PekinPekin, Illinois  61603
Illinois CancerCare-PeruPeru, Illinois  61354
Illinois CancerCare-PrincetonPrinceton, Illinois  61356
Illinois CancerCare-Spring ValleySpring Valley, Illinois  61362
Michiana Hematology Oncology PC-ElkhartElkhart, Indiana  46514
Michiana Hematology Oncology PC-PlymouthPlymouth, Indiana  46563
Michiana Hematology Oncology PC-South BendSouth Bend, Indiana  46601
Michiana Hematology Oncology-PC WestvilleWestville, Indiana  46391
Cancer Center of Kansas-LiberalLiberal, Kansas  67901
Saint Mary's Regional Medical CenterLewiston, Maine  04240
Maine Medical Center- Scarborough CampusScarborough, Maine  04074
Saint Agnes HospitalBaltimore, Maryland  21229
The Memorial Hospital at EastonEaston, Maryland  21601
Memorial Hospital at Easton - Shore Regional Cancer CenterEaston, Maryland  21601
Commonwealth Hematology Oncology PC-ConcordConcord, Massachusetts  01742
Commonwealth Hematology Oncology PC-HaverhillHaverhill, Massachusetts  01830
Commonwealth Hematology Oncology PC-LawrenceLawrence, Massachusetts  01842
Commonwealth Hematology Oncology PC-StonehamStoneham, Massachusetts  02180
Commonwealth Hematology Oncology PC-WeymouthWeymouth, Massachusetts  02190
Commonwealth Hematology Oncology PC-WorcesterWorcester, Massachusetts  01605
University of Michigan University HospitalAnn Arbor, Michigan  48109
Michiana Hematology Oncology PC-NilesNiles, Michigan  49120
Central Care Cancer Center-Carrie J Babb Cancer CenterBolivar, Missouri  65613
Skaggs Cancer CenterBranson, Missouri  65616
University of Missouri - Ellis FischelColumbia, Missouri  65203
Veterans AdministrationColumbia, Missouri  65201
Renown Regional Medical CenterReno, Nevada  89502
John F Kennedy Medical CenterEdison, New Jersey  08818
Hackensack University Medical CCOPHackensack, New Jersey  07601
UMDNJ - New Jersey Medical SchoolNewark, New Jersey  07103
AtlantiCare Regional Medical Center -Main CampusPomona, New Jersey  08240
Syracuse Veterans Administration Medical CenterSyracuse, New York  13210
Carolinas Medical Center - NortheastConcord, North Carolina  28025
Moses Cone Health System-Regional Cancer CenterGreensboro, North Carolina  27403
East Carolina UniversityGreenville, North Carolina  27858
Maria Parham HospitalHenderson, North Carolina  27536
Rex Cancer CenterRaleigh, North Carolina  27607
Duke Raleigh HospitalRaleigh, North Carolina  27609
Annie Penn Memorial HospitalReidsville, North Carolina  27320
North Coast Cancer Care-ClydeClyde, Ohio  43410
Community Health Partners Regional Medical CenterElyria, Ohio  44035
Stark, Michael, Edward. M.D. (UIA Investigator)Toledo, Ohio  43623
Saint John Medical CenterTulsa, Oklahoma  74104
Oncology Hematology Associates of Northern PennsylvaniaDubois, Pennsylvania  15801
The Regional Cancer CenterErie, Pennsylvania  16505
Armstrong Center for Medicine and HealthKittanning, Pennsylvania  16201
Saint Mary Medical and Regional Cancer CenterLanghorne, Pennsylvania  19047
Chestnut Hill Health SystemPhiladelphia, Pennsylvania  19118
Roper HospitalCharleston, South Carolina  29401
Cancer Centers of the Carolinas - FarisGreenville, South Carolina  29605
Cancer Centers of the Carolinas-Greer Radiation OncologyGreer, South Carolina  29650
Cancer Centers of the Carolinas-Greer Medical OncologyGreer, South Carolina  29650
Erlanger Medical CenterChattanooga, Tennessee  37403
Vanderbilt-Ingram Cancer Center Cool SpringsFranklin, Tennessee  37067
The Center for Biomedical ResearchKnoxville, Tennessee  37909
East Tennessee Baptist Hospital-Mercy Health PartnersKnoxville, Tennessee  37920
University of Tennessee - KnoxvilleKnoxville, Tennessee  37920
Nashville Oncology Associates PCNashville, Tennessee  37203
Texas Oncology-Austin NorthAustin, Texas  78759
Texas Oncology-Austin MidtownAustin, Texas  78705
Texas Oncology - Central Austin Cancer CenterAustin, Texas  78731
Texas Oncology - South Austin Cancer CenterAustin, Texas  78745
Texas Oncology-Cedar ParkCedar Park, Texas  78613
Saint Paul HospitalDallas, Texas  75235
Texas Oncology-Seton WilliamsonRound Rock, Texas  78665
Texas Oncology - Round Rock Cancer CenterRound Rock, Texas  78681
Texas Oncology- San MarcosSan Marcos, Texas  78666
Sandra L Maxwell Cancer CenterCedar City, Utah  84720
Intermountain Medical CenterMurray, Utah  84157
Utah Valley Regional Medical CenterProvo, Utah  84603
Dixie Medical Center Regional Cancer CenterSaint George, Utah  84770
Intermountain Health CareSalt Lake City, Utah  84103
Utah Cancer Specialists-Salt Lake CitySalt Lake City, Utah  84106
Southwestern Vermont Medical CenterBennington, Vermont  05201
Mount Ascutney Hospital and Health CenterWindsor, Vermont  05089
Virginia Oncology Associates-HamptonHampton, Virginia  23666
Skagit Valley HospitalMt. Vernon, Washington  98273
Evergreen Hematology and Oncology PSSpokane, Washington  99218
West Virginia University CharlestonCharleston, West Virginia  25304
Marshfield Clinic-Chippewa CenterChippewa Falls, Wisconsin  54729
Holy Family Memorial HospitalManitowoc, Wisconsin  54221
Aurora Advanced Healthcare Inc-MequonMequon, Wisconsin  53092
Wheaton Franciscan Healthcare - Saint JosephMilwaukee, Wisconsin  53210
Medical Consultants LimitedMilwaukee, Wisconsin  53215
Wheaton Franciscan Cancer Care - All SaintsRacine, Wisconsin  53405
Vince Lombardi Cancer Clinic-SheboyganSheboygan, Wisconsin  53081
Vince Lombardi Cancer Clinic - SlingerSlinger, Wisconsin  53086
Marshfield Clinic Cancer Care at Saint Michael's HospitalStevens Point, Wisconsin  54481
Aurora Medical Center in SummitSummit, Wisconsin  53066
Vince Lombardi Cancer ClinicTwo Rivers, Wisconsin  54241
Riverview HospitalWisconsin Rapids, Wisconsin  54494
Cancer Centers of Southwest Oklahoma ResearchLawton, Oklahoma  
San Francisco General HospitalSan Francisco, California  94110
Stanford University Hospitals and ClinicsStanford, California  94305
Siouxland Hematology Oncology AssociatesSioux City, Iowa  51101
IU Health ArnettLafayette, Indiana  
Georgia Health Sciences UniversityAugusta, Georgia  30912
Alta Bates Summit Medical Center-Herrick CampusBerkeley, California  94704
Boca Raton Regional HospitalBoca Raton, Florida  33486
Carle Foundation - Carle Cancer CenterUrbana, Illinois  61801
Michiana Hematology Oncology PC-MishawakaMishawaka, Indiana  46545-1470
Oncology Associates at Mercy Medical CenterCedar Rapids, Iowa  52403
Marie Yeager Cancer CenterSaint Joseph, Michigan  49085
Sanford Clinic North-FargoFargo, North Dakota  58102
Sanford Medical Center-FargoFargo, North Dakota  58122
Summa Akron City HospitalAkron, Ohio  44304
The Toledo Hospital/Toledo Children's HospitalToledo, Ohio  43606
Sanford USD Medical Center - Sioux FallsSioux Falls, South Dakota  57117-5134
Providence Sacred Heart Medical Center and Children's HospitalSpokane, Washington  99204
Genesys Regional Medical Center-West Flint CampusFlint, Michigan  48532
Sanford Clinic North-BemidgiBemidji, Minnesota  56601
Essentia Health Duluth Clinic CCOPDuluth, Minnesota  55805
Essentia Health Saint Mary's Medical CenterDuluth, Minnesota  55805
Sanford Bismarck Medical CenterBismarck, North Dakota  58501
Toledo Clinic Cancer Centers-OregonOregon, Ohio  43616
Veterans Administration-San Diego Medical CenterSan Diego, California  92161
Community Howard Regional HealthKokomo, Indiana  46904
Indiana University Health La Porte HospitalLa Porte, Indiana  46350
Saint Joseph Regional Medical Center-MishawakaMishawaka, Indiana  46545-1470
Essentia Health Cancer Center-South University ClinicFargo, North Dakota  58103
PeaceHealth Saint Joseph Medical CenterBellingham, Washington  98225
Group Health Cooperative of Puget Sound Oncology ConsortiumSeattle, Washington  98109
Aurora Cancer Care-BurlingtonBurlington, Wisconsin  53105
Aurora Cancer Care-FranklinFranklin, Wisconsin  53132
Aurora Cancer Care-GlendaleGlendale, Wisconsin  53212
Aurora Cancer Care-Kenosha SouthKenosha, Wisconsin  53142
Aurora Cancer Care-Milwaukee SouthMilwaukee, Wisconsin  53215
Aurora Cancer Care-RacineRacine, Wisconsin  53406-5661
Aurora Cancer Care-WaukeshaWaukesha, Wisconsin  53188
Aurora Cancer Care-Milwaukee WestWauwatosa, Wisconsin  53226
Christiana Care Health System-Christiana HospitalNewark, Delaware  19718
Illinois Cancer Specialists-NilesNiles, Illinois  60714
Bronson Battle CreekBattle Creek, Michigan  49017
Riverview Medical Center/Booker Cancer CenterRed Bank, New Jersey  07701
Springfield Regional Medical CenterSpringfield, Ohio  45505
Cancer Specialists of North Florida-Orange ParkOrange Park, Florida  32073
The James Graham Brown Cancer Center at University of LouisvilleLouisville, Kentucky  40202
NEA Baptist Memorial HospitalJonesboro, Arkansas  72401
Marin Cancer Care IncGreenbrae, California  94904
Augusta Oncology Associates PC-Saint SebastianAugusta, Georgia  30901
Edward Hospital/Cancer CenterNaperville, Illinois  60540
Promise Regional Medical Center-HutchinsonHutchinson, Kansas  65702
Saint Vincent Hospital/Reliant Medical GroupWorcester, Massachusetts  01608
Lake Region Healthcare Corporation-Cancer CareFergus Falls, Minnesota  56537
Saint Louis Cancer and Breast Institute-South CitySaint Louis, Missouri  63109
Nevada Cancer Institute-Summerlin CampusLas Vegas, Nevada  89135
Toledo Clinic Cancer Centers-Bowling GreenBowling Green, Ohio  43402
Toledo Clinic Cancer Centers-MaumeeMaumee, Ohio  43537-1839
Toledo Clinic Cancer Centers-ToledoToledo, Ohio  43623
PinnacleHealth Fox Chase Regional Cancer Center at Polyclinic HospitalHarrisburg, Pennsylvania  17110
Guthrie Clinic-Robert Packer HospitalSayre, Pennsylvania  18840
Self Regional HealthcareGreenwood, South Carolina  29646
Harrison Poulsbo Hematology and OncologyPoulsbo, Washington  98370
Providence Holy Family HospitalSpokane, Washington  99208
PeaceHealth Southwest Medical CenterVancouver, Washington  98664
Aurora Cancer Care-Southern LakesElkhorn, Wisconsin  53121
Mayo Clinic Health System-Franciscan HealthcareLa Crosse, Wisconsin  54601