Feasibility of A Reduced Dexamethasone Pre-Medication Dose in Elderly Patients Treated With Weekly Docetaxel
Dose-limiting edema and effusions associated with cumulative docetaxel administraton have
necessitated the recommendation that all patients should be premedicated with oral
corticosteroids such as dexamethasone prior to docetaxel administration. Dexamethasone
pre-medication may also decrease the incidence and severity of acute hypersensitivity
reactions associated with docetaxel administration. However, administration of weekly
dexamethasone can cause additional untoward side effects, especially in the older
population. If the data from this phase II study is encouraging, a study to evaluate an
even lower dose of dexamethasone can be conducted.
Interventional
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
To evaluate the feasibility of a reduced dexamethasone pre-medication dose in elderly lung and breast cancer patients receiving weekly docetaxel therapy with respect to incidence of: Grade 3/4 fluid retention
William Ershler, MD
Principal Investigator
Geriatric Oncology Consortium
United States: Institutional Review Board
GOC S-010
NCT00215748
August 2004
April 2007
Name | Location |
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Baltimore, Maryland 21287 |