Inclusion Criteria:

- Female, age > 18 years.

- Histologic or cytologic diagnosis of breast carcinoma.

- Stage II to IV breast cancer with measurable primary breast tumor, defined as
palpable tumor with both diameters 2.0cm or greater as measured by caliper.

- Patients must not have received prior chemotherapy or hormonal therapy for the
treatment of breast cancer.

- Karnofsky performance status of 70 or higher.

- Estimated life expectancy of at least 12 weeks.

- Adequate organ function including the following:

- Bone marrow: White blood cells (WBC) >= 3.5 x 109/L Absolute neutrophil (segmented
and bands) count (ANC) >= 1.5 x 109/L Platelets >= 100 x 109/L Haemoglobin >= 9g/dL

- Hepatic: Bilirubin <= 1.5 x upper limit of normal (ULN), ALT or AST <= 2.5x ULN,
(or <=5 X with liver metastases) Alkaline phosphatase <= 2.5x ULN.

- Renal: creatinine <= 1.5x ULN

- Cardiac:

- Adequate cardiac function

- Signed informed consent from patient or legal representative.

- Patients with reproductive potential must use an approved contraceptive method if
appropriate (eg, intrauterine device, birth control pills, or barrier device) during
and for three months after the study. Females with childbearing potential must have a
negative serum pregnancy test within 7 days prior to study enrollment.

Exclusion Criteria:

- Prior treatment for locally advanced or metastatic breast cancer.

- Treatment within the last 30 days with any investigational drug.

- Concurrent administration of any other tumor therapy, including cytotoxic
chemotherapy, hormonal therapy, and immunotherapy.

- Active infection that in the opinion of the investigator would compromise the
patient's ability to tolerate therapy.

- Pregnancy.

- Breast feeding.

- Serious concomitant disorders that would compromise the safety of the patient or
compromise the patient's ability to complete the study, at the discretion of the
investigator.

- Poorly controlled diabetes mellitus.

- Second primary malignancy that is clinically detectable at the time of consideration
for study enrollment.

- Symptomatic brain metastasis.

- History of significant neurological or mental disorder, including seizures or
dementia.

- Peripheral neuropathy of >= CTC grade 2.

- History of hypersensitivity to drugs formulated in Tween 80, the vehicle used for
commercial docetaxel formulations.