Inclusion Criteria:

1. Histological or cytological diagnosis of non-Hodgkin's lymphoma.

2. Diagnostic sample obtained by stereotactic or surgical biopsy, CSF cytology
examination or vitrectomy.

3. Disease exclusively localized into the central nervous system, cranial nerves or
eyes.

4. Untreated patients (patients treated with steroids alone are eligible).

5. At least one measurable lesion.

6. Age 18 - 75 years.

7. ECOG performance status < 3

8. HBsAg-negative and Ab anti-HCV-negative serologic status.

9. No known HIV disease or immunodeficiency.

10. Adequate bone marrow (PLT > 100000 mm3, Hb ≥ 9 g/dl, ANC ≥ 2.000 mm3), renal
(creatinine clearance ≥ 60 mL/min), cardiac (VEF ≥ 50%), and hepatic function (total
serum bilirubin < 3 mg/dL, AST/ALT and gGT < 2 per upper normal limit value).

11. No previous or concurrent malignancies with the exception of surgically cured
cervical intraepithelial neoplasia type 1 (CIN1) or localized non-melanomatous skin
cancer and of other cancers without evidence of disease since at least 5 years
(patients with a previous lymphoma diagnosis will be excluded).

12. Absence of any familial, sociological or geographical condition potentially hampering
compliance with the study protocol and follow-up schedule.

13. Non-pregnant and non-lactating status for female patients. Adequate contraceptive
measures during study participation for sexually active patients of childbearing
potential.

14. No concurrent treatment with other experimental drugs.

15. Informed consent signed by the patient before registration