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The Survey About Resting Metabolic Rate and Its Related Factors in Terminal Patients

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Trial Information

The Survey About Resting Metabolic Rate and Its Related Factors in Terminal Patients

According to data from the Taiwanese government, cancer mortality has been the leading cause
of death in Taiwan since 1982. The trend is increasing day by day. As the people are aging
in Taiwan, the incidence of cancer will increase and it will be more important than before.

Cachectic patients often lose their appetite, lose weight, and are prone to weakness and
even death in advanced illness. Nutrition therapy is important and of concern to the
investigators in cancer patients. More than 80% of terminal cancer or advanced illness
patients get cachexia. Cachexia is a complex, multifactorial syndrome that results from a
reduction in food intake, a variety of metabolic abnormalities (including hypermetabolism)
or more often a combination of the two. Cachexia will progress with disease progression.
Cachexia or weight loss is often the major cause of death or poor quality of life.

The change of resting energy expenditure (REE) is different in various tumor types. Most
experts agree that the REE will increase in cancer cachexia syndrome. The more weight loss,
the more cachexia will occur.

Overnutrition is not beneficial in terminal patients according to the Chiu and Easson
studies. As the investigators know, few studies focus on REE in terminal patients. In this
study, samples are from a hospice palliative ward or from hospice home care patients in a
medical center in mid-Taiwan. About 100 patients will be recruited. The investigators will
analyze the relationship between REE and its related factors. After finishing the study,
they will provide more evidence for treating cachexia in terminal patients.

Inclusion Criteria:

- Terminal cancer patients who were admitted to a hospice palliative ward in one
medical center located in mid-Taiwan

Exclusion Criteria:

- Patient could not complete the examination of resting metabolic rate using MedGerm

Type of Study:


Study Design:

Observational Model: Case-Only, Time Perspective: Cross-Sectional

Principal Investigator

Wen-Yuan Lin, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

China Medical University Hospital


Taiwan: Department of Health

Study ID:




Start Date:

July 2005

Completion Date:

Related Keywords:

  • Advanced Cancers
  • resting energy expenditure
  • cachexia
  • advanced cancer
  • advanced cancer patients
  • Neoplasms