Long-Term Study of the Efficacy and Safety of Lansoprazole in the Treatment of Zollinger-Ellison and Other Acid Hypersecretors
The aim of this protocol is to study the medical management of acid hypersecretory states
including Zollinger-Ellison using Prevacid. The immediate objective is to heal peptic ulcers
and eliminate symptoms and in the long term to prevent relapse of symptoms, lesions and
complications. Other objectives include observation of the efficacy in controlling gastric
acid production and of the safety of high dose, long-term use of Prevacid.
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Long-term Medical(Non-surgical)Control of Gastric Acid Production Assessed From Time of Study Enrollment, up to 240 Months Post Enrollment.
number of participants with control of gastric acid production
up to 240 months from study enrollment
C. Mel Wilcox, M.D.
University of Alabama at Birmingham
United States: Institutional Review Board