Inclusion Criteria:

- Recently diagnosed MM according to the criteria of the South West Oncology Group
(SWOG)

- Not previously treated, apart from local radiotherapy, in the case of a threatening
or incapacitating lesion, and/or a 4-day block of dexamethasone (40 mg/mL) in an
emergency

- Stage II or III disease according to the Durie and Salmon classification or Stage I
disease with symptomatic bone lesion

- < 65 years of age

- Ability to give signed informed consent

- Secretion of a measurable monoclonal spike (> 10 g/l in the serum or 0.2 g/24h in the
urine)

- Negative pregnancy test at inclusion (if necessary)

- Absence of active infection. In the case of infection, appropriate antibiotic therapy
must be administered and patients must have been apyretic for 48 hours before the
start of treatment with VAD or Velcade®/dexamethasone

Exclusion Criteria:

- ECOG performance status > 2

- History of cancer (other than basal cell carcinoma or carcinoma of the cervix in
situ)

- Life expectancy < 2 months

- Confirmed amyloidosis

- Positive HIV serology

- Serious psychiatric item in the history

- Renal failure requiring dialysis

- Uncontrolled diabetes, contra-indicating the use of corticosteroids

- Peripheral neuropathy National Cancer Institute (NCI) grade > 2 (Annex 5)

- Clinical signs of heart failure or coronary heart disease

- Bilirubin > 3 x normal

- Transaminases or gamma-glutamyl transpeptidase (GT) > 4 x normal

- Platelets < 50 x 10^9/l during the 15 days prior to inclusion

- Neutrophils < 0.75 x 10^9/l during the 15 days prior to inclusion

- Use of an investigational medicinal product during the 30 days prior to inclusion

- Known hypersensitivity to bortezomib, boron or mannitol