Inclusion Criteria:

- Histologic or serologic proof of metastatic germ cell neoplasm(gonadal or
extragonadal primary) with disease not amenable to cure with either surgery or
chemotherapy. Patients w/ seminoma and non-seminoma are eligible, as are women w/
ovarian germ cell tumors.

- Evidence of recurrent or metastatic carcinoma

- Must have received initial cisplatin combination therapy & demonstrated progression
following the administration of at least one "salvage" regimen for advanced germ cell
neoplasms.

- Patients are eligible after first line platinum bsed chemotherapy if their disease
has relapsed and they have primary mediastinal non seminomatous germ cell tumor, late
relapse or progressed w/in 4 wks of last platinum dose.

- immunohistochemical documentation of EGFR expression documented.

- adequate organ function: ANC >/=150,plt >100K, total bili normal(ULN). Pts w/ liver mets up to 3x ULN.Transaminases up to 1.5 x ULN if alk phos
is mets may have alk phos up to 5x ULN. Serum crt
- ECOG performance status 0-2.

Exclusion Criteria:

- Must be 3 weeks post major surgery, radiotherapy, or chemotherapy and hae recovered
from all toxicity.

- Active unresolved infection and/or are receiving concurrent treatment with parenteral
antibiotics are ineligible.

- Patients requiring steroids for symptomatic brain metastasis are not eligible.

- Pregnant or lactating patients are not eligible.

- Class III/IV heart disease