Inclusion Criteria:

Patients must have either:

- Stage IV, microscopically-confirmed carcinoma of the breast with:

- Relapse or progression while receiving, or within 12 months of having received,
an anthracycline-containing (doxorubicin or mitoxantrone) or taxane-containing
(paclitaxel or docetaxel) regimen as either adjuvant treatment or therapy for
advanced breast cancer, or

- Treatment to a maximum dose of anthracycline (e.g., greater than 450 mg/m2 of
doxorubicin), or

- A dose-limiting toxicity from a taxane, or

- An ECOG performance status of 2.

- OR —

- Unresectable or metastatic, microscopically-confirmed soft tissue sarcoma, that is
not amenable to treatment with Adriamycin or Ifosfamide due to:

- Poor cardiac reserve, or

- Poor performance status (ECOG performance status = 2) or

- Having failed treatment with Adriamycin or reached dose-limiting toxicity from
chemotherapy.

Patients must have histologic slides and/or blocks must be available for review.

Patients must have measurable (bidimensionally) or evaluable disease.

Patients must be 18 years old or older.

Patients must have Karnofsky Performance Status greater than 70% (ECOG less than 2) at
screen and on the first day of treatment.

Patients must have a life expectancy more than 16 weeks.

Patients must be informed consent must be obtained prior to enrollment.

Patients must be more than 2 weeks from prior surgery; more than 3 weeks from radiation
therapy to the pelvis, spine or long bones; more than 3 weeks from prior chemotherapy
(more than 6 weeks for mitomycin C or nitrosureas), or more than 2 weeks from prior
hormonal therapy.

Exclusion Criteria:

Granulocytes less than 1,500/mm3.

Platelet count less than 100,000/mm3.

Hemoglobin less than 10 gm/dl.

Creatinine greater than 2.0 mg/dl.

Total bilirubin greater than ULN (institutional upper limit of normal).

Visceral crisis characterized by rapidly progressive hepatic or lymphangitic lung
metastases (i.e. patients whose disease is beyond control).

Medically unstable (i.e. with uncontrolled disease); diagnosis of other systemic cancer.

Pregnancy or lactation; failure to employ adequate contraception.

Uncontrolled CNS disease.

Greater than 30% marrow previously irradiated.

Psychological, familial, sociological or geographical conditions which do not permit
weekly medical follow-up and compliance with the study protocol.