Inclusion Criteria:

To be included in this study, you must meet the following criteria:

- Her-2 positive metastatic breast cancer confirmed by biopsy

- Measurable disease

- Able to perform activities of daily living without considerable

- No previous chemotherapy with gemcitabine

- No more than one prior chemotherapy regimen for metastatic breast cancer

- Adequate bone marrow, liver and renal function

- Normal heart function

- Give written informed consent prior to entering this study.

Exclusion Criteria:

You cannot participate in this study if any of the following apply to you:

- Received previous treatment with gemcitabine

- History of brain metastases

- Serious underlying medical conditions

Please note: There are additional inclusion/exclusion criteria. The study center will
determine if you meet all of the criteria. If you do not qualify for the trial, study
personnel will explain the reasons. If you do qualify, study personnel will explain the
trial in detail and answer any questions you may have.