Inclusion Criteria:

- Histologically proven adenocarcinoma

- No obvious primary on routine history, physical examination, and investigations

- Patients greater than or equal to 18 years of age

- ECOG Performance Status 0-1

- Patients requiring opioids for pain control must be on a fixed analgesic regimen
aimed to provide adequate pain control with no more than 3 breakthrough
(supplemental) doses of analgesics per day to control pain; Additional inclusion
criteria due apply, but not are not listed here.

Exclusion Criteria:

- Have received treatment within the last 30 days with a drug that has not received
regulatory approval for any indication at the time of study entry

- Unable to stabilize pain and analgesics for a period of 7 days prior to starting
study treatment

- Prior treatment with chemotherapy

- Bilirubin greater than or equal to 40 mol/L

- AST or ALT greater than or equal to 5 times the upper limit of normal (ULN);
Additional exclusion criteria due apply, but not are not listed here.