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Optical Quantification of Breast Density Changes Due to Hormone Treatment, Pregnancy and Breast-feeding.

25 Years
45 Years
Not Enrolling
Breast Cancer

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Trial Information

Optical Quantification of Breast Density Changes Due to Hormone Treatment, Pregnancy and Breast-feeding.

Breast density is an established physical risk factor for breast cancer, applicable to the
entire female population in a pre-breast-screening program and, unlike other risk factors,
was shown to be affected by an intervention treatment. High breast tissue density is
associated with increased risk of breast cancer. Transillumination Breast Spectroscopy
(TIBS) uses a white light to provide spectral information on breast tissue density and
composition (e.g. water, lipid, hemoglobin and other biomolecules). The overall goal of the
TIBS program is to develop a technique that can identify individuals at high risk for breast
cancer who would benefit most from improved screening methods and a risk reducing
intervention (e.g. diet and lifestyle changes) and can monitor the efficacy of the risk
reducing intervention itself in an individual. In a previous study, we demonstrated a high
correlation between breast density assessed by TIBS and density identified by x-ray
mammography. The current study is testing TIBS ability to monitor changes in an
individual's breast density over time

Inclusion Criteria:

- Be in good health and able to provide consent

- Be between 25 and 45 years of age

- Be pre-menopausal

- Are willing to come in to Princess Margaret Hospital (Toronto, Ontario, Canada) for
up to 12 visits at intervals of about three months

Exclusion Criteria:

- Have had a full term pregnancy

- Have had breast biopsy

- Have had breast augmentation or reduction

Type of Study:


Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Principal Investigator

Lothar Lilge, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada M5G 2M9; Department of Biophysics and Bioimaging, University of Toronto, Ontario, Canada M5G 2M9


Canada: Health Canada

Study ID:




Start Date:

May 2004

Completion Date:

September 2010

Related Keywords:

  • Breast Cancer
  • Breast Transillumination Spectroscopy
  • Optical Transillumination Spectroscopy
  • Breast Cancer Risk
  • Breast Neoplasms