Trial Information

Optical Quantification of Breast Density Changes Due to Hormone Treatment, Pregnancy and Breast-feeding.

Breast density is an established physical risk factor for breast cancer, applicable to the
entire female population in a pre-breast-screening program and, unlike other risk factors,
was shown to be affected by an intervention treatment. High breast tissue density is
associated with increased risk of breast cancer. Transillumination Breast Spectroscopy
(TIBS) uses a white light to provide spectral information on breast tissue density and
composition (e.g. water, lipid, hemoglobin and other biomolecules). The overall goal of the
TIBS program is to develop a technique that can identify individuals at high risk for breast
cancer who would benefit most from improved screening methods and a risk reducing
intervention (e.g. diet and lifestyle changes) and can monitor the efficacy of the risk
reducing intervention itself in an individual. In a previous study, we demonstrated a high
correlation between breast density assessed by TIBS and density identified by x-ray
mammography. The current study is testing TIBS ability to monitor changes in an
individual's breast density over time