Know Cancer

forgot password

Transillumination for Breast Cancer Risk Assessment

30 Years
70 Years
Not Enrolling
Breast Cancer

Thank you

Trial Information

Transillumination for Breast Cancer Risk Assessment

In a previous cross sectional study in a group of women without breast cancer and with
varying degrees of parenchymal density patterns, a strong association was demonstrated
between Transillumination Breast Spectroscopy (TIBS) and x-ray derived mammographic density.
From this, we expect that TIBS should also provide a comparable odds ratio (4-6) as
mammographic density for breast cancer risk shown in other independent epidemiological
studies. It is possible that TIBS may provide complementary information and a higher odds
ratio if compared to the incidence of breast cancer. In contrast to mammography derived
parenchymal density pattern, no historical TIBS data is available for a retrospective
analysis and hence a cross sectional study within a group of screened women is proposed. We
hypothesize that TIBS provides physical information about the breast tissue which can be
used to construct a breast cancer risk predictor with an odd ratio > 6.

Inclusion Criteria:

- Are in good health and capable of providing consent

- Are willing to come in to the Princess Margaret Hospital for a single visit to meet
with a female research assistant

Exclusion Criteria:

- Have had breast augmentation or reduction

- Have a personal history of breast cancer

- Have had a previous bilateral fine needle aspiration or core biopsy

- Have a breast tattoo

Type of Study:


Study Design:

Observational Model: Case Control, Time Perspective: Cross-Sectional

Principal Investigator

Lothar Lilge, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada M5G 2M9; Department of Biophysics and Bioimaging, University of Toronto, Toronto, Ontario, Canada M5G 2M9


Canada: Health Canada

Study ID:




Start Date:

July 2006

Completion Date:

September 2009

Related Keywords:

  • Breast Cancer
  • Breast Cancer Risk
  • Optical Transillumination Spectroscopy
  • Transillumination Breast Spectroscopy
  • Breast Neoplasms