Optical Transillumination Spectroscopy of Breast Tissue in Pre- and Post-Menopausal Women.
X-ray generated images, such as mammograms, rely on the density of tissue within the breast.
Tissue density are believed to be associated with proliferation of stroma and/or
epithelium, which result in an increase in water associated light absorption and a decrease
in lipid associated light absorption. The amount of density of the breast tissue has been
shown to be an indicator of cancer risk. Thus, assessing this breast tissue density is also
an important tool in determining breast cancer risk.
Optical transillumination has been shown to give information about tissue composition and
tissue density. Unlike x-ray mammography which uses ionizing radiation, optical
transillumination uses normal white light and is deemed safe to be used frequently for women
of all ages and therefore can be used for those situations where mammography is not an
Normal white light is shone into the tissue and the light that leaves the breast on the
other side from the source is detected and analyzed. Since the same physiological
conditions that contribute to dense breast tissue, as seen in mammography, also will have
unique optical signatures.
We will compare the amount of this dense tissue from the mammogram, taken with 12 months, to
the density measurements found through the optical procedure. The goal is to be able to
duplicate the information from the mammogram using the transillumination technique. All
measurements are non-invasive and no blood samples or biopsies are required.
Observational Model: Cohort, Time Perspective: Cross-Sectional
Lothar Lilge, PhD
Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada M5G 2M9; Department of Biophysics and Bioimaging, University of Toronto, Toronto, Ontario, Canada M5G 2M9
Canada: Ethics Review Committee