Surveillance Low Dose Computed Tomography of the Thorax in Patients With High Grade Extremity Soft Tissue Sarcoma
A 3-year prospective phase II non-randomized study commenced May 2003 enrolling 60 high-risk
patients with Intermediate and High Grade STS. Each patient is kept under radiological
surveillance for 3 years unless lung metastases are detected. Conventional thoracic imaging
for staging and surveillance of STS patients is shown in Figure 1. In the trial, LDCT and
MnDCT are added to each imaging visit (Figure 1). A 2-view CXR (CR) is performed (Direct
View, Kodak, Rochester) followed by thoracic CT scans performed on a Siemens 16 row MDCT
(Sensation 16, Siemens, Erlangen), CT acquisition; 120kVp, 5/2.5/2.5mm. Images are
reconstructed with high and low spatial frequency filters and soft copy viewing is performed
on a standalone PACS workstation using standard mediastinal (w 350, l 40) and lung (w 1500,
l -600) settings. Examinations are performed with varying mAs; SDCT 120 mAs, LDCT 40 mAs and
MnDCT 20 mAs. The examinations are evaluated, blinded to the results of the alternative and
previous studies, for the presence of nodules (defined as a non-calcified focal opacity ≥3
mm < 3 cm). Surveillance imaging is commenced 3 months post surgery.
Interventional
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Detection of metastases
Narinder Paul, FCPC C
Principal Investigator
University Health Network, Toronto
Canada: Health Canada
03-0468-CE
NCT00188422
August 2003
January 2006
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