Comprehensive Prostate MRI for the Evaluation of Prostate Cancer at 3.0T: A Pilot Study
Progress in effective local therapy of prostate cancer has been stymied by the lack of an
imaging technique capable of reliably identifying the location of cancer within the
prostate. Magnetic Resonance Imaging is a promising candidate for imaging the prostate
because of its high soft tissue contrast, multiplanar capabilities, and the potential for
providing unique biologic information not available with other modalities. In addition to
conventional T2-weighted imaging MRI techniques that provide unique biologic information
include MR spectroscopy, diffusion weighted MRI, dynamic enhanced MRI and hypoxia imaging.
All have shown promise in imaging tumors at a magnetic field strength of 1.5 Tesla but all
have been limited by sensitivity. Since MR signal is proportional to magnetic field
strength, 3.0 Tesla clinical systems potentially could improve overall diagnostic accuracy.
A comprehensive imaging package which incorporates all these techniques to study prostate
cancer on a state-of-the-art 3.0 Tesla magnet has not yet been developed.
In this pilot study we seek to develop and evaluate a comprehensive prostate MR exam at 3.0
Tesla. Patients with biopsy proven prostate cancer will undergo an MRI with endorectal and
surface phased array coils which will include conventional sequences, MR spectroscopy,
Diffusion weighted MRI, Dynamic enhanced MR and Hypoxia imaging. In the development phase
of this trial (30 patients), the robustness of the techniques and test-retest
reproducibility will be evaluated. In the second phase, the comprehensive prostate MRI exam
will be validated against the results of prostate biopsy (50 patients). The expected
accrual period is two years. We hope that this method will offer prostate cancer patients a
more accurate method of localizing their prostate cancer than is now possible which should
improve outcomes and minimize complications of treatment.
United States: Federal Government
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Bethesda, Maryland 20892|