Storing Blood for Analysis of DNA and Protein of Patients With Hodgkin Lymphoma in MAASTRO Clinic
It has already been known for a long time that cancer is a genetic disorder and that the
development of the illness is a very complex interaction between genetic and surrounding
factors. Also the response on therapy and the development and seriousness of side effects is
stipulated by this complicated collaboration of genetic and surrounding factors. Moreover it
is not only the DNA that plays an important role but also the systems of control at protein
level. At this moment a lot of questions remain to be answered because up till now the
studies were of rather restricted statistical strength with frequently inconsistent dates
and moreover retrospective. Major retrospective studies are necessary to distinguish the
relationship between DNA/protein patterns and clinical relevant endpoints like prognosis and
toxicity in which an as broad as possible patient group is being monitored. For this reason
we want to collect blood samples in MAASTRO clinic of all patients with hodgkin lymphoma and
store it encrypted so that we can perform DNA and protein analyses in future and to
correlate the results with survival and toxicity of the treatment.
Observational
Observational Model: Cohort, Time Perspective: Prospective
Dirk De Ruysscher, PHD
Principal Investigator
CCMO
Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)
P03.1248L
NCT00181467
September 2004
March 2010
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