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Mamma Board Project: Prone Breast Irradiation for Pendulous Breasts

18 Years
Open (Enrolling)
Breast Cancer

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Trial Information

Mamma Board Project: Prone Breast Irradiation for Pendulous Breasts

Local excision followed by adjuvant radiotherapy has become standard treatment for women
with early-stage breast cancer. Adjuvant radiotherapy may encounter technical difficulties
in patients with pendulous breasts when treated in supine position.

Based upon literature and our own preliminary experiences, we hypothesize that for large
pendulous breasts, breast irradiation in supine and prone position are equivalent with
regard to coverage of the PTV, but with a better dose homogeneity in prone position and a
smaller radiation exposure of lung and heart. However, no quantitative data are yet
available to test this hypothesis. Therefore, the aim of our study is to compare the 3-D
dose distribution in PTV and normal tissues in prone position versus supine position.

Inclusion Criteria:

- Patients should have had breast-conserving surgery for breast cancer or DCIS

- No indication for radiotherapy of regional nodes

- Large, pendulous breasts (bra size D and over)

Exclusion Criteria:

- Regional radiotherapy is indicated

- Unable to lie in prone position

Type of Study:


Study Design:

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

In 10 patients a conventional simulation will be done in supine and prone position. A planning CT-scan will be obtained in both positions. A lead wire will be placed around the palpable breast tissue as an aid in the delineation.

Principal Investigator

Jeroen Buijsen, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Maastricht Radiation Oncology


Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Study ID:




Start Date:

December 2003

Completion Date:

January 2010

Related Keywords:

  • Breast Cancer
  • Breast cancer
  • Breast conserving surgery
  • Radiotherapy
  • Pendulous breasts
  • Breast Neoplasms