Mamma Board Project: Prone Breast Irradiation for Pendulous Breasts
Local excision followed by adjuvant radiotherapy has become standard treatment for women
with early-stage breast cancer. Adjuvant radiotherapy may encounter technical difficulties
in patients with pendulous breasts when treated in supine position.
Based upon literature and our own preliminary experiences, we hypothesize that for large
pendulous breasts, breast irradiation in supine and prone position are equivalent with
regard to coverage of the PTV, but with a better dose homogeneity in prone position and a
smaller radiation exposure of lung and heart. However, no quantitative data are yet
available to test this hypothesis. Therefore, the aim of our study is to compare the 3-D
dose distribution in PTV and normal tissues in prone position versus supine position.
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
In 10 patients a conventional simulation will be done in supine and prone position. A planning CT-scan will be obtained in both positions. A lead wire will be placed around the palpable breast tissue as an aid in the delineation.
Jeroen Buijsen, MD
Maastricht Radiation Oncology
Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)