Inclusion Criteria:

- *Adult male or female, age 18 to 75 years

- HCV RNA positive by PCR

- Previous treatment with at least three months of interferon or interferon /
Ribavirin. Patients should have had no interferon for at least 2 months prior to
enrollment.

1. Non-responders are identified by failure to clear virus by PCR after a
minimum 3-month course of treatment and who have been off treatment for at
least 2 months with a positive PCR for HCV prior to entry into the current
study, 2) Partial responders have a reduction of 1 long in HCV RNA, but the
virus is still detectable, 3) Breakthrough patients have been negative on
treatment, but virus appeared while still on treatment, 4) Relapsers are
defined as negative PCR at some point during treatment, but virus
reoccurred or was detectable by HCV PCR when treatment stopped.

Patients should have had a liver biopsy showing at least Stage 3 disease prior to being
considered for this study. A baseline liver biopsy is necessary for inclusion in the
study. Baseline liver biopsies can be performed within six months of entering the study.

In patients with cirrhosis and endoscopic evidence of portal hypertension, a biopsy within
the last 2 years is acceptable as the baseline biopsy. For patients with established
cirrhosis on liver biopsy and no portal hypertension, a biopsy within 12 months can be
used as the baseline biopsy if it is available for evaluation by the Pathology core. All
these patients will still require liver biopsy at 2 years and 4 years. The decision to
biopsy at 2 and 4 years is also a clinical decision and in the presence of clinical
progression or coagulopathy, or where there may be a risk from liver biopsy, the
Investigator should call the PI, Dr. Afdhal for a waiver of biopsy. Patients with Ishak
Stage 3 and 4 require a biopsy within 6 months of randomization.

- Hemoglobin >= 11 g/dl in males and 10 g/dl in females

- Neutrophil count > 1,500/mm3

- Platelets > 50, 000/mm3

Platelet count: For standard dose of PEG-Intron 0.5mcg/kg platelet count must be greater
than 70,000. Patients with platelet count 50 - 70,000 can start at 0.25mcg/kg for weeks 0
- 4. If platelets fall to less than 30,000, stop treatment. If platelets remain > 50,000
at week 4, PEG-Intron can be increased to 0.5mcg/kg. Patients randomized to Colchicine
with platelets 50,000 - 70,000 can be started at standard dose 0.6mg bid po with standard
dose reduction.

- Prothrombin time <= 3secs prolonged compared to control or an equivalent INR < 1.5

- Total bilirubin < 3gm/dL

- Fasting blood sugar <= 115 mg/dl or within 20% of the upper limit of normal for
non-diabetic patients

- Albumin (> 2.8mg/dl)

- Serum creatinine < 1.4 mg/dL

- TSH within the normal range (Patients with thyroid disease who are well controlled
are eligible if the remainder of the inclusion/exclusion criteria are met)

- HIV negative.

- HBsAg negative

- Childs Pugh score of less than or equal to 7

- Serum positive for anti-hepatitis C antibodies or HCV RNA.

- Alpha-fetoprotein < 100ng/ml with ultrasound negative for focal mass or HCC. For
any patient with an Alpha-fetoprotein >100 ng/ml either a triple phase contrast
CT scan or MRI with gadolinium must show no focal mass or evidence of HCC

- Ultrasound with no evidence of focal mass suggestive of hepatoma (within 6
months of informed consent).

- Documentation that sexually active female patients of childbearing potential are
practicing adequate contraception during the treatment period. A urine
pregnancy test obtained at entry prior to the initiation of treatment must be
negative. Female patients must not be breast-feeding. Documentation that
sexually active male patients are practicing acceptable methods of contraception
during the treatment period.

- Written informed consent specific for this protocol has been obtained prior to
entry.

Exclusion Criteria:

- Any cause of liver disease based on patient history and biopsy (where applicable)
other than chronic hepatitis C including but not limited to:

- Co-infection with hepatitis B or HIV

- Hemochromatosis (confirmed by genetic testing)

- Alpha-1 antitrypsin deficiency

- Wilson's disease

- Renal or liver transplant patients

- Autoimmune hepatitis

- Alcoholic liver disease

- Obesity induced liver disease

- Drug related liver disease

In addition:

- Evidence of decompensated liver disease such as a history or presence of ascites, and
spontaneous encephalopathy. Patients with past bleeding esophageal varices that have
not bled for more than 1 year can be included.

- Hypersensitivity to alpha interferon

- Drug related liver disease

- Hemoglobinopathies (e.g. Thalassaemia, sickle cell disease).

- Patients with clinically significant retinal abnormalities.

- Substance abuse, such as alcohol (·> 80 gm/day), I.V. drugs and inhaled drugs. If
the patient has a history of substance abuse, to be considered for inclusion into the
protocol, the patient must have abstained from using the abused substance for at
least 6 months. Patients on methadone will be allowed in the study with no
restrictions as is now standard of care in HCV therapy.

- Patients with a history of organ transplantation will be excluded.

Preexisting psychiatric conditions, especially depression, or a history of severe
psychiatric disorder, such as major psychoses, suicidal ideation and/or suicidal attempt
are excluded. Patients with a history of mild depression may enter the protocol if they
meet the following eligibility criterion and are monitored more intensively.

Mild depression: to include either situational depression of a limited period or
depressive symptoms, which do not significantly interfere with the patient's work or daily
functions.

Any patient with an active manic element to his/her previous symptom complex will be
excluded.

Any known pre-existing medical condition that could interfere with the patient's
participation in and completion of the study such as:

- Pre-existing psychiatric condition, especially severe depression, or a history of
severe psychiatric disorder

- CNS trauma or seizure disorder requiring therapy

- Significant cardiac dysfunction in the previous 6 months e.g. angina, CCF,
hypertension or arrhythmia Patients on treatment are eligible as long as they have
been symptom free for the previous 6 months.

- Poorly controlled diabetes mellitus

- Chronic pulmonary disease (e.g. COAD)

- Immunologically mediated diseases (e.g. inflammatory bowel disease, SLE, ITP,
autoimmune hemolytic anemia, scleroderma, rheumatoid arthritis, severe psoriasis)

- Clinical gout

- Patients with clinically significant retinal abnormalities

- Patients with organ transplants

Any other condition, which in the view of the investigator, would make the patient
unsuitable for enrolment, or could interfere with the patient participating in and
completing the protocol are included as well.