Inclusion Criteria:

- Patients eligible for transplantation under this protocol will be <35 years of age,
and will be diagnosed with:

- a bone marrow failure syndrome unresponsive to available therapy, including but
not limited to Diamond-Blackfan anemia, Shwachman Diamond syndrome or Kostmann's
neutropenia but exclusive of aplastic anemia.

- Diamond Blackfan Anemia:

- Patients must show evidence of steroid resistance requiring equivalent of >6
transfusions yearly despite steroid therapy.

- Evidence of developing aplasia or myelodysplasia will also be criteria for
transplantation.

- Kostmann's Neutropenia, Shwachman-Diamond syndrome:

- Patients must have been previously diagnosed as having a clinical picture
characteristic of Shwachman-Diamond syndrome (exocrine pancreatic insufficiency,
growth retardation, metaphyseal dysostosis, neutropenia), or must have a bone
marrow aspirate consistent with Kostmann's neutropenia, with no evidence of
acute leukemia.

- Patients must have failed therapy with granulocyte-colony stimulating factor
(G-CSF), as determined by an inability to maintain an absolute neutrophil count
(ANC) >750 cells/ml(3), or manifesting recurrent infections despite G-CSF
administration resulting in life threatening infections or repeated
hospitalizations (<4 /year).

Exclusion Criteria:

- Patients >35 years of age

- Karnofsky score <70%

- Hepatic dysfunction as determined by bilirubin >3.0, ALT >150, or active hepatitis

- Pulmonary function tests with forced volume vital capacity (FVC) and forced
expiratory volume (FEV) <70%; O2 saturation <94%

- Renal dysfunction with glomerular filtration rate (GFR) <30% of predicted.

- Cardiac compromise, with left ejection fraction <45%.

- Severe, stable neurologic impairment.

- Human immunodeficiency virus (HIV) positivity.

- Pregnant or lactating females