The Effects of Curcuminoids on Aberrant Crypt Foci in the Human Colon
Laboratory studies have indicated that this agent, which is derived from plants and found in
foods we eat, has anti-inflammatory properties and prevents colon cancer in animal studies.
ACFs are small abnormalities in the lining of the colon that with time may grow into
colorectal adenomas (also called polyps, growths or small masses of tissue on the lining of
the colon or rectum which have the potential to become cancerous) which can then grow into
adenocarcinomas (cancer) in the colon or rectum.
Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention
To evaluate the effects of curcumin or the NSAID sulindac on the number of ACF in the left colon and rectum of normal volunteers found to have them on an initial magnifying chromoendoscopic screening exam
Yang CS, MD
University of Medicine and Dentistry New Jersey
United States: Food and Drug Administration
|Cancer Institute of New Jersey||New Brunswick, New Jersey 08901|