Know Cancer

forgot password

18 Years
50 Years
Open (Enrolling)
Cervical Cancer, Breast Cancer, Endometrial Cancer, Cancer

Thank you

Trial Information

In our extended studies, we have directly examined the expressions of various inhibitory
natural killer cell Receptors (iNKRs) on Tumor-infiltrating lymphocytes (TILs) derived from
human Cervical cancer (CC) by triple-color flow cytometry with combination of different
surface markers. We found up-regulated expression of certain iNKRs (CD94/NKG2A) in TILs and
in mixed lymphocyte-cancer cell cocultures. In our previous studies, we demonstrated that
certain cytokines, including IL-10, TGF-beta (Sheu et al, Journal of Immunology, 2001,
167:2972-2978), and IL-15 (Sheu et al, Cancer Research, 2005, 65:2921-2929) can be expressed
by CC cells. We further demonstrated that activated T cells bear iNKRs which inhibit
cytotoxic activity. iNKRs are proposed to restrain the T cell receptor (TCR)-mediated
cytolysis. We found that CC cells had altered HLA-A, -B, and -C molecules in a cancer
microenvironment. The acquisition of both NK-like activity and expression of iNKRs by these
T cells is parallel to prevent damage to normal host cells. However, there is also limited
knowledge about the regulatory role of iNKR expression in T cell cytotoxicity.

Inclusion Criteria:

- Cancer patients

- Healthy volunteers

Exclusion Criteria:

- Immunosuppression

- HIV carrier

Type of Study:


Study Design:


Principal Investigator

Bor-Ching Sheu, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Department of Obstetrics and Gynecology, National Taiwan University Hospital


Taiwan: Department of Health

Study ID:




Start Date:

July 2004

Completion Date:

December 2006

Related Keywords:

  • Cervical Cancer
  • Breast Cancer
  • Endometrial Cancer
  • Cancer
  • Cervical cancer
  • Breast cancer
  • T lymphocyte
  • NK receptor
  • Breast Neoplasms
  • Endometrial Neoplasms
  • Uterine Cervical Neoplasms
  • Adenoma