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Screening for CRC Using a Mixed Strategy of Sigmoidoscopy and Colonoscopy in Average-Risk Population According to Age

50 Years
Open (Enrolling)
Colorectal Cancer

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Trial Information

Screening for CRC Using a Mixed Strategy of Sigmoidoscopy and Colonoscopy in Average-Risk Population According to Age

Because the prevalence of proximal colon cancer and APN was higher in older patients15, a
greater proportion of advanced colonic neoplasia or cancer would be missed if colonoscopy
was not performed for older patients. So if we develop a mixed strategy to offer
sigmoidoscopy for younger patients and reserve colonoscopy for older patients, we might be
able to detect more APN with fewer colonoscopic procedures. We aimed to determine an optimal
cut-off age and choose an appropriate distal sentinel lesion for subsequent colonoscopy.

Inclusion Criteria:

- Only asymptomatic ethnic Chinese subjects aged 50 years or older who underwent total
colonoscopy were included in this study

Exclusion Criteria:

- Persons with symptoms indicative of colorectal cancer, such as hematochezia, body
weight loss, development of persistent abdominal pain or rectal pain, and a change in
bowel habit, were excluded from this study. Other exclusion criteria were: (1) past
history of CRC, colon polyps, or inflammatory bowel disease; (2) a history of
screening tests, including FOBT, sigmoidoscopy, colonoscopy, or barium studies within
5 years; (3) any first degree relative(s) with colon cancer; (4) criteria for
hereditary nonpolyposis colorectal cancer, familial adenomatous polyposis, or other
polyposis syndrome; (5) obvious anemia with hemoglobin level less than 10g/dl; (6)
incomplete examination of entire colon, including poor colon preparation and failure
to reach cecum.

Type of Study:


Study Design:

Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Cross-Sectional, Time Perspective: Retrospective/Prospective

Principal Investigator

Ming-Shiang Wu, MD, PhD

Investigator Role:

Study Director

Investigator Affiliation:

Departments of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan


Taiwan: Department of Health

Study ID:




Start Date:

June 2003

Completion Date:

July 2004

Related Keywords:

  • Colorectal Cancer
  • colorectal cancer screening
  • colonoscopy
  • Colorectal Neoplasms