Proton Magnetic Resonance Spectroscopy (1H MRS) in Evaluating the Bone Marrow, Muscle and Adipose Tissue on Normal and Human Immunodeficiency Virus Infected Subjects, With Serial Follow-Up
Magnetic resonance spectroscopy (MRS) is commonly applied in medicine with 1H proton or
31-phosphorus spectra. The proton MRS is often used in evaluating the central nervous system
and 31P MRS is used in muscular diseases or neoplasms. However, the proton MRS is also
considered to be applied to the musculoskeletal system because of its profound amount of
protons. Ballon used the STEAM technique, and Schick used the PRESS technique, to
investigate the lipid and water spectra of the bone marrow and also correlated those with
hematological diseases and post-treatment effects. Schellinger et al. used the STEAM
sequence to calculate the lipid content of the vertebral bone marrow and found that it was
influenced according to age and sex. The investigator had used the proton MRS to evaluate
the lipid and water spectra of the femoral head and revealed its significance in predicting
avascular necrosis of the femoral head. According to the above research literature, the
investigators considered further investigation of the proton MRS in evaluating the
musculoskeletal system.
Observational
Observational Model: Defined Population, Observational Model: Natural History, Time Perspective: Cross-Sectional, Time Perspective: Prospective
Tiffany Ting-Fang Shih, M.D.
Principal Investigator
Department of Medical Imaging, National Taiwan University Hospital
Taiwan: Department of Health
9261701422
NCT00172315
December 2003
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