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Proton Magnetic Resonance Spectroscopy (1H MRS) in Evaluating the Bone Marrow, Muscle and Adipose Tissue on Normal and Human Immunodeficiency Virus Infected Subjects, With Serial Follow-Up


Phase 3
20 Years
70 Years
Open (Enrolling)
Both
Acquired Immunodeficiency Syndrome, Lipodystrophy

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Trial Information

Proton Magnetic Resonance Spectroscopy (1H MRS) in Evaluating the Bone Marrow, Muscle and Adipose Tissue on Normal and Human Immunodeficiency Virus Infected Subjects, With Serial Follow-Up


Magnetic resonance spectroscopy (MRS) is commonly applied in medicine with 1H proton or
31-phosphorus spectra. The proton MRS is often used in evaluating the central nervous system
and 31P MRS is used in muscular diseases or neoplasms. However, the proton MRS is also
considered to be applied to the musculoskeletal system because of its profound amount of
protons. Ballon used the STEAM technique, and Schick used the PRESS technique, to
investigate the lipid and water spectra of the bone marrow and also correlated those with
hematological diseases and post-treatment effects. Schellinger et al. used the STEAM
sequence to calculate the lipid content of the vertebral bone marrow and found that it was
influenced according to age and sex. The investigator had used the proton MRS to evaluate
the lipid and water spectra of the femoral head and revealed its significance in predicting
avascular necrosis of the femoral head. According to the above research literature, the
investigators considered further investigation of the proton MRS in evaluating the
musculoskeletal system.


Inclusion Criteria:



- Patients with a diagnosis of acquired immunodeficiency syndrome (AIDS)

- Normal volunteers

Exclusion Criteria:

- AIDS patients with newly developed neoplasms

Type of Study:

Observational

Study Design:

Observational Model: Defined Population, Observational Model: Natural History, Time Perspective: Cross-Sectional, Time Perspective: Prospective

Principal Investigator

Tiffany Ting-Fang Shih, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

Department of Medical Imaging, National Taiwan University Hospital

Authority:

Taiwan: Department of Health

Study ID:

9261701422

NCT ID:

NCT00172315

Start Date:

December 2003

Completion Date:

Related Keywords:

  • Acquired Immunodeficiency Syndrome
  • Lipodystrophy
  • acquired immunodeficiency syndrome
  • lipodystrophy
  • MR spectroscopy
  • Acquired Immunodeficiency Syndrome
  • HIV Infections
  • Immunologic Deficiency Syndromes
  • Lipodystrophy

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