Genotoxicity Assessment for Patients Receiving Large Field Irradiation
Correlative studies: analysis of RT effect on genotoxicity by assessing cytogenetic changes
(dicentrics), micronucleated lymphocytes (MN-lymph), and micronucleated reticulocytes
(MN-RET) using peripheral blood of patients receiving radiation.
i) document the kinetics by which radiation-induced MN-RET enter the peripheral blood
ii) benchmark the MN-RET endpoint against current gold-standard biodosimetry
endpoints—dicentrics and MN-lymphocytes.
iii) measure inter-individual variation in baseline and radiation-induced MN-RET
iv) in collaboration with several FCM-equipped laboratories, evaluate the transferability of
the human MN-RET scoring assay.
Observational Model: Cohort, Time Perspective: Prospective
Measure the Change in MN-RET in the blood
Baseline and 1 day
Yuhchyau Chen, MD, Ph.D
Universtiy of Rochester, Dept of Radiation Oncology
United States: Institutional Review Board
|University of Rochester, Dept. Radiation Oncology||Rochester, New York 14642|