Trial Information

Genotoxicity Assessment for Patients Receiving Large Field Irradiation

Correlative studies: analysis of RT effect on genotoxicity by assessing cytogenetic changes
(dicentrics), micronucleated lymphocytes (MN-lymph), and micronucleated reticulocytes
(MN-RET) using peripheral blood of patients receiving radiation.

i) document the kinetics by which radiation-induced MN-RET enter the peripheral blood
stream.

ii) benchmark the MN-RET endpoint against current gold-standard biodosimetry
endpoints—dicentrics and MN-lymphocytes.

iii) measure inter-individual variation in baseline and radiation-induced MN-RET
frequencies.

iv) in collaboration with several FCM-equipped laboratories, evaluate the transferability of
the human MN-RET scoring assay.