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Evaluation of Thiopurine Methyltransferase Polymorphisms in the Hispanic Population


Phase 4
N/A
18 Years
Not Enrolling
Both
Cancer

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Trial Information

Evaluation of Thiopurine Methyltransferase Polymorphisms in the Hispanic Population


Relatively few studies have been performed evaluating the variant allele frequencies in
Spanish populations. To date, no studies evaluating the TPMT variant allele frequency in the
Hispanic population have been reported. Hispanics are a growing part of the patient
population treated in the United States. Characterization of the proportion of patients with
variant genotypes in this population is important since Hispanic children represent a
significant proportion of children being treated with thiopurines.

A single 3 cc heparinized blood sample will be obtained for TPMT genotyping. The sample will
be obtained either simultaneously with a clinical sample, at the time of an otherwise
medically indicated intravenous catheter placement or scavenged from excess blood remaining
following clinical laboratory testing.


Inclusion Criteria:



- All Hispanic children and adolescents diagnosed and treated at Texas Children's
Cancer Center within the last 5 years for malignant diseases/cancer and non-malignant
hematological disorders that necessitate chemotherapy

- All Hispanic children and adolescents who will be treated at Texas Children's Center
for malignant diseases/cancer and non-malignant hematological disorders that will
necessitate chemotherapy.

Exclusion Criteria:

- Any child or adolescent registering at Texas Children's Cancer Center and not
requiring any form of therapy.

Type of Study:

Observational

Study Design:

N/A

Authority:

United States: Federal Government

Study ID:

PPRU-10728

NCT ID:

NCT00166647

Start Date:

February 2004

Completion Date:

Related Keywords:

  • Cancer
  • Cancer
  • Chemotherapy
  • Hematological disorder

Name

Location

Baylor College of Medicine, Texas Children's HospitalHouston, Texas  77030