Inclusion Criteria:

- Histological confirmation of a low-grade glioma (astrocytoma, oligodendroglioma, or
mixed oligoastrocytoma)

- Measurable disease on MRI

- Patients that have undergone recent resection for newly diagnosed or recurrent or
progressive tumor are eligible if they have recovered from the effects of surgery.

- Patients with recurrent disease my have had one prior chemotherapy regimen

- Older than 18 years of age.

- Karnofsky performance status (KPS) performance score of > 70%

- Adequate hematologic, renal and liver functions,

- Life expectancy of greater than 12 weeks.

- Negative pregnancy test.

Exclusion Criteria:

- Prior treatment with temozolomide

- Patients who are not neurologically stable

- Acute infection treated with intravenous antibiotics

- Non-malignant systemic disease

- Frequent vomiting, inability to swallow or a medical condition that could interfere
with oral medication.

- Previous or concurrent malignancies at other sites, with the exception of surgically
cured carcinoma in-situ of the cervix, and basal or squamous cell carcinoma of the
skin.

- HIV positive or AIDS-related illness

- Pregnant or nursing women

- Patients with allergy to decarbazine.