Inclusion Criteria:

- Older than 18 years of age.

- Confirmed diagnosis of active progressive multiple myeloma

- History of > 2 prior cytotoxic treatment regimens. Bone marrow transplantation will
be considered as one regimen.

- Current measurable disease based on serum and/or urine M protein and/or measurable
plasmacytoma.

- Eastern Cooperative Oncology Group (ECOG) performance status of 0-2

- Absolute neutrophil count (ANC) > 1,500 mm3

- Platelets > 100,000 mm3

- Serum creatinine < 1.5 upper limit of normal (ULN)

- Serum bilirubin < 1.5 ULN

- AST/AGOT and ALT/SGPT < 3.0 ULN

- Life expectancy > 12 weeks

Exclusion Criteria:

- Chemotherapy < 3 weeks prior to registration.

- Biologic or immunotherapy < 2 weeks prior to registration

- Full field radiotherapy < 4 weeks or limited field radiotherapy < 2 weeks prior to
registration.

- History or presence of central nervous system (CNS) disease

- History of leukemia

- History of another primary malignancy with the exception of inactive basal or
squamous cell carcinoma of the skin

- Major surgery < 4 weeks prior to registration

- Prior therapy with anti-vascular endothelial growth factor (VEGF) agents excluding
thalidomide, Revimid, velcade and arsenic trioxide

- Interstitial pneumonia or extensive and symptomatic interstitial fibrosis of the lung

- Pleural effusion or ascites that cause respiratory compromise

- Female patients that are pregnant or breast feeding

- Uncontrolled high blood pressure, history of labile hypertension or history of poor
compliance with an antihypertensive regimen

- Unstable angina pectoris

- Symptomatic congestive heart failure

- Myocardial infarction < 6 months prior to registration

- Serious uncontrolled cardiac arrhythmia

- Uncontrolled diabetes

- Active or uncontrolled infection

- Acute or chronic liver disease

- Impairment of gastrointestinal (GI) function or GI disease

- Confirmed HIV infection