Inclusion Criteria:

- RA for at least 1 year

- Clear clinical signs of active RA in 1 knee joint

- Meet ARA (1987) criteria for diagnosis of RA and ACR (1991) criteria for RA
functional classes I, II, or III

- Inadequate clinical response to a minimum of 3 months of therapy with
anti-TNF-blocking agents

- Taking background DMARDs for a minimum of 3 months and at stable doses for at least
28 days

Exclusion Criteria:

- Serious bacterial infection in last 3 months

- History of TB

- History of cancer within 5 years

- Evidence of latent or active bacterial or viral infection

- Intra-articular corticosteroids within 3 months

- Exposure to live vaccines

- Exposure to CTLA4Ig or BMS-188667

- Treatment with immunoadsorption column(s), mycophenolate mofetil, leflunomide,
anakinra, cyclosporine, etanercept, adalimumab, infliximab, azathioprine, oral or
parenteral gold, D-penacillamine, calcineurin inhibitors, cyclophosphamide or other
alkylating agents