Molecular Analysis of Genetic Elements Which May Influence Predisposition and Prognosis of Hematological Malignancies in Different Ethnic Groups in Israel
18 Years
N/A
Both
Acute Myeloid Leukemia, Chronic Lymphocytic Leukemia, Chronic Myelogenous Leukemia
Trial Information
Molecular Analysis of Genetic Elements Which May Influence Predisposition and Prognosis of Hematological Malignancies in Different Ethnic Groups in Israel
We have prepared DNA on patients with leukemia (AML, CML and CLL) and we are studying the
influence of polymorphisms in drug metabolism and disposition genes on predisposition and
prognosis of these types of leukemia. The genes we are studying include: MDR1, CYP3A4, NQO1,
NAT1/2, GST, hOCT. We plan to study other genes that may be contributory.
Study includes comparing the frequency of polymorphisms in these genes with the frequency in
the general population and the study of DNA biding proteins which bind at the sites of these
polymorphisms.
Inclusion Criteria:
- diagnosis of acute myeloid leukemia or chronic lymphocytic leukemia
Exclusion Criteria:
- under 18 years of age
Type of Study:
Observational
Study Design:
Time Perspective: Prospective
Principal Investigator
Deborah G Rund, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Hadassah Medical Organization
Authority:
Israel: Israeli Health Ministry Pharmaceutical Administration
Study ID:
132910-HMO-CTIL
NCT ID:
NCT00159003
Start Date:
January 1998
Completion Date:
April 2012
Related Keywords:
- Acute Myeloid Leukemia
- Chronic Lymphocytic Leukemia
- Chronic Myelogenous Leukemia
- drug metabolism and disposition enzymes
- Disease Susceptibility
- Leukemia
- Leukemia, Lymphocytic, Chronic, B-Cell
- Leukemia, Lymphoid
- Leukemia, Myeloid, Acute
- Leukemia, Myeloid
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Hematologic Neoplasms
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