Inclusion Criteria:

- patients with primary ovarian cancer

- ECOG- 0-2

- Age >= 18

- no chemotherapy, radiation or immunotherapy in medical history for ovarian cancer

- adequate bone marrow, liver and kidney reserve: leukocytes ≥ 2.0 x 109/l, platelets
≥ 100 x 109/l, bilirubin <= 2,0 mg%, creatinine <= 1,5 mg% or creatinine clearance ≥
60 ml/ min, hemoglobin ≥ 9 g/ dl SGOT, SGPT an AP within 3 fold of the reference
laboratory's normal range

- written informed consent

Exclusion Criteria:

- before-existing heart illness, Cardiac infarct within last 6 months

- Radiotherapy within 4 weeks for study entry

- Patients in pregnancy or breast feeding (in premenopausal women anticonception has to
be assured: intrauterine devices, surgical methods of sterilization, or, in hormone
insensitive tumors only, oral, subcutaneous or transvaginal hormonal, non-estrogen
containing contraceptives)