Effect of Polymorphisms in the IL-1 Gene Complex on the Development of Chronic Hepatitis and Hepatocellular Carcinoma
We analyzed single-nucleotide polymorphisms in the genes for interleukin-1a, interleukin-1b,
interleukin-1-receptor antagonist, interleukin-1-receptor type I, and interleukin-1-receptor
type II in 400 normal control and patients (chronic hepatitis and hepatocellular carcinoma).
Genotypes were tested for an association with development of chronic hepatitis and
hepatocellular carcinoma by multivariable analysis. A second cohort of 1200 normal control
and patients (chronic hepatitis and hepatocellular carcinoma) was independently analyzed for
the genotype associations identified in the first cohort.
Observational Model: Case Control, Observational Model: Natural History, Time Perspective: Longitudinal, Time Perspective: Retrospective
Li-Hui Tseng, M.D., Ph.D.
National Taiwan University Hospital
Taiwan: Department of Health