Effect of Polymorphisms in the IL-1 Gene Complex on the Development of Chronic Hepatitis and Hepatocellular Carcinoma
18 Years
N/A
Both
Hepatitis B, Carcinoma, Hepatocellular, Polymorphism, Genetic
Trial Information
Effect of Polymorphisms in the IL-1 Gene Complex on the Development of Chronic Hepatitis and Hepatocellular Carcinoma
We analyzed single-nucleotide polymorphisms in the genes for interleukin-1a, interleukin-1b,
interleukin-1-receptor antagonist, interleukin-1-receptor type I, and interleukin-1-receptor
type II in 400 normal control and patients (chronic hepatitis and hepatocellular carcinoma).
Genotypes were tested for an association with development of chronic hepatitis and
hepatocellular carcinoma by multivariable analysis. A second cohort of 1200 normal control
and patients (chronic hepatitis and hepatocellular carcinoma) was independently analyzed for
the genotype associations identified in the first cohort.
Inclusion Criteria:
- Normal controls
- Cases of chronic hepatitis and hepatocellular carcinoma
Exclusion Criteria:
- Pregnant women
Type of Study:
Observational
Study Design:
Observational Model: Case Control, Observational Model: Natural History, Time Perspective: Longitudinal, Time Perspective: Retrospective
Principal Investigator
Li-Hui Tseng, M.D., Ph.D.
Investigator Role:
Study Chair
Investigator Affiliation:
National Taiwan University Hospital
Authority:
Taiwan: Department of Health
Study ID:
9361700927
NCT ID:
NCT00155103
Start Date:
August 2004
Completion Date:
Related Keywords:
- Hepatitis B
- Carcinoma, Hepatocellular
- Polymorphism, Genetic
- Hepatitis B
- Carcinoma, Hepatocellular
- Polymorphism, Genetic
- Carcinoma
- Hepatitis
- Hepatitis A
- Hepatitis B
- Hepatitis, Chronic
- Carcinoma, Hepatocellular
Name | Location |
|---|
