A Randomized, Multi-Center, Phase II Study to Investigate the Safety and Efficacy of SDX-101 (R-etodolac) in Combination With Chlorambucil, and That of Chlorambucil Alone, in Patients With Chronic Lymphocytic Leukemia (CLL)
1. Diagnosis of B-cell CLL by standard clinical and immunophenotypic criteria as
specified by the NCI working group revised guidelines for diagnosis and treatment of
2. Binet stages A-C with evidence of active disease requiring treatment by the presence
of one or more of the following at the time of study entry:
- Disease related B symptoms (Fever > 38C [100.5F] for ≥ 2 weeks without evidence
of infection, night sweats without evidence of infection, weight loss > 10%
within previous 6 mo.).
- Evidence of progressive marrow failure as manifested by:
- A decrease in hemoglobin to < 10g/dL, or
- A decrease in platelet count to < 100 x 10(9)/L within the previous 6 months, or
- A decrease in absolute neutrophil count (ANC) to < 1.0 x 10(9)/L within 6 months
- Progressive lymphocytosis with an increase of > 50% over a 2 month period, or an
anticipated doubling time of < 6 months.
- Massive nodes or clusters(i.e., > 10 cm in longest diameter) or progressive
- Progressive splenomegaly to > 2cm below the left costal margin or other
organomegaly with progressive increase over 2 consecutive clinical visits ≥ 2
3. No prior chemotherapy for CLL.
4. Age ≥ 18 at signing of informed consent.
5. World Health Organization (WHO) performance status ≤ 0-2 (Appendix B).
6. Platelet count > 50,000/μL, hemoglobin > 8.0 g/dl and absolute neutrophil count
7. Renal function ≤ 1.5 x upper limit normal (blood urea nitrogen [BUN], serum
8. Liver function ≤ 1.5 times upper limit of normal (total bilirubin, SGOT (AST) and
SGPT (ALT) values).
9. Female patients of childbearing potential must have a negative pregnancy test (serum
or urine Beta-human chorionic gonadotropin, Beta-HCG); men and women of reproductive
potential must employ effective contraceptive methods while on study therapy, and for
2 months following completion of treatment.
10. Signed EC/IRB-approved informed consent by patient prior to all study related
1. Active autoimmune manifestation of CLL such as ongoing hemolytic anemia or ITP
2. History of a second malignancy with the exception of cervical cancer,or resected
basal cell carcinoma or other malignancies with no evidence of recurrence 5 or more
years since diagnosis.
3. Chronic viral infection: positive hepatitis B or hepatitis C serology, known positive
for human immunodeficiency virus (HIV) or human T-leukemia/lymphoma virus (HTLV).
4. Transformation to an aggressive B-cell malignancy such as Richter's transformation,
prolymphocytic leukemia (PLL) or large B-cell lymphoma.
5. Clinical evidence of CNS involvement with CLL.
6. Serious infection, medical condition, or psychiatric condition that, in the opinion
of the investigator, might interfere with the achievement of the study objectives.
7. Treatment with any investigational agent within 4 weeks of study entry.
8. The use of steroids, nonsteroidal anti-inflammatory drugs, regardless of indication
(excluding prophylactic use of aspirin for prevention of acute myocardial infarction
9. Pregnancy or currently breast feeding.