Inclusion Criteria:

- Histologically or cytologically confirmed diagnosis of invasive breast cancer, Stage
IV disease

- Age greater than 18 years

- At least one measurable target lesion as defined by RECIST that has not been
previously treated with local therapy

- HER2-negative breast cancer

- Up to one prior chemotherapy for advanced or metastatic disease

- ECOG performance status 0-1

- Life expectancy > 12 weeks

- Adequate liver and bone marrow function: AST < 2.5 x ULN; Bilirubin < 1.5 x ULN; ANC
> 1,500/ul; platelet count > 100,000/ul; normal PT and PTT

- At least 2 weeks since prior radiation and recovered from treatment-related toxicity

Exclusion Criteria:

- Prior taxanes for treatment of metastatic disease

- Pregnant of breast-feeding women

- HER2-positive breast cancer

- More than 1 prior chemotherapy regimen for metastatic disease

- Untreated brain metastases

- Concurrent radiotherapy or investigational drug

- Prior bone marrow or stem cell transplant

- History of other malignancy within the last 5 years, not including curatively-treated
carcinoma in situ of the cervix or non-melanoma skin cancer

- Uncontrolled infection

- Active bleeding, or history of bleeding requiring transfusion

- Active cardiac disease

- Serious medical or psychiatric illness