Inclusion Criteria:

- Pathological confirmed squamous cell carcinoma of the larynx.

- TNM-classification (UICC 1997, appendix I):

- T3-4 glottic or supraglottic carcinoma

- T2 glottic carcinoma with impaired cord mobility or subglottic extension

- T2 supraglottic carcinoma with invasion of mucosa of base of tongue or vallecula or
invasion of the medial wall of the piriform sinus.

- any N-stage, M0.

- WHO performance status 0 or 1 (appendix II).

- Age > 18 years.

- Written informed consent.

- Quality of life questionnaire completed.

Exclusion Criteria:

- Prior or concurrent treatment for this tumour.

- Severe stridor and adequate debulking of airway not possible.

- Impaired renal function: serum creatinine above upper normal limit.

- Use of nefrotoxic medication (including ACE-inhibitors) that cannot be discontinued
for the duration of the radiation treatment.

- Impaired hepatic function: ASAT and ALAT more than 1.5 times the upper normal limit.

- Use of anti-convulsants that cannot be discontinued for the duration of the radiation
treatment.

- History of malignancy during the previous 5 years except basal cell carcinoma of
skin, carcinoma in situ of the cervix, or superficial bladder neoplasm (pTa).