Inclusion Criteria:

1. cytologically, histologically proven small-cell lung cancer

2. limited disease

3. age 20-70 years old

4. performance status of 0-1

5. measurable disease

6. no prior treatment for small-cell lung cancer

7. no history of chemotherapy

8. adequate organ functions

9. written informed consent

Exclusion Criteria:

1. pericardial effusion

2. active concomitant malignancy

3. pregnant or lactating women

4. interstitial pneumonia/active lung fibrosis on chest x-ray, watery diarrhea,
intestinal obstruction or paralysis, uncontrolled heart disease or a history of
myocardial infarction within the previous 6 months, uncontrolled diabetes mellitus,
active infection, psychological disease deemed unacceptable for inclusion to the
study, long-term steroid treatment.