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Cost Effectiveness of Two Different Implementation Procedures to Change Clinicians Practice Roles in the Detection of Hereditary Colorectal Cancer


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Open (Enrolling)
Both
Colorectal Neoplasms, Hereditary Nonpolyposis Colorectal Cancer

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Trial Information

Cost Effectiveness of Two Different Implementation Procedures to Change Clinicians Practice Roles in the Detection of Hereditary Colorectal Cancer


The Radboud University Nijmegen Medical Centre developed a new method to identify patients
with HNPCC. This method appeared cost-effective and feasible. Using this new method 70% of
the HNPCC patients will be identified as compared to less than 30% when the current method
is used. However, this new method does not implement itself; large gaps exists between best
evidence and daily practice. This study will compare an intensive strategy, consisting of
distribution of educational materials, education, feedback and reminders, with a minimal
strategy, only consisting of distribution of a critical care pathway. The aim is to find the
most cost-effective strategy to implement the new method to identify patients with HNPCC in
the Netherlands.


Inclusion Criteria:



- Colorectal cancer before the age of 50 years

- Second colorectal cancer at any age

- Colorectal cancer and other HNPCC associated extracolonic cancer irrespective of age
at diagnosis

- Adenoma with high grade dysplasia diagnosed before the age of 40 years

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind

Outcome Measure:

Efficacy of inclusion of eligible CRC-patients for MSI testing by pathologists.

Principal Investigator

Nicoline Hoogerbrugge, MD PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Department of Human Genetics, Radboud University Nijmegen Medical Center

Authority:

Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Study ID:

MIPA-2005

NCT ID:

NCT00141466

Start Date:

September 2005

Completion Date:

July 2007

Related Keywords:

  • Colorectal Neoplasms
  • Hereditary Nonpolyposis Colorectal Cancer
  • Hereditary colorectal cancer
  • Microsatellite instability
  • Physician roles
  • Health care implementation
  • Intervention
  • Neoplasms
  • Colorectal Neoplasms
  • Colorectal Neoplasms, Hereditary Nonpolyposis

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