Cost Effectiveness of Two Different Implementation Procedures to Change Clinicians Practice Roles in the Detection of Hereditary Colorectal Cancer
The Radboud University Nijmegen Medical Centre developed a new method to identify patients
with HNPCC. This method appeared cost-effective and feasible. Using this new method 70% of
the HNPCC patients will be identified as compared to less than 30% when the current method
is used. However, this new method does not implement itself; large gaps exists between best
evidence and daily practice. This study will compare an intensive strategy, consisting of
distribution of educational materials, education, feedback and reminders, with a minimal
strategy, only consisting of distribution of a critical care pathway. The aim is to find the
most cost-effective strategy to implement the new method to identify patients with HNPCC in
the Netherlands.
Interventional
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind
Efficacy of inclusion of eligible CRC-patients for MSI testing by pathologists.
Nicoline Hoogerbrugge, MD PhD
Principal Investigator
Department of Human Genetics, Radboud University Nijmegen Medical Center
Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)
MIPA-2005
NCT00141466
September 2005
July 2007
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