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Phase III Study of Docetaxel and Atrasentan Versus Docetaxel and Placebo for Patients With Advanced Hormone Refractory Prostate Cancer

Phase 3
18 Years
Open (Enrolling)
Metastatic Cancer, Prostate Cancer

Thank you

Trial Information

Phase III Study of Docetaxel and Atrasentan Versus Docetaxel and Placebo for Patients With Advanced Hormone Refractory Prostate Cancer



- Compare the survival and progression-free survival of patients with hormone-refractory
stage IV prostate cancer and bone metastases treated with docetaxel and prednisone
combined with either atrasentan vs placebo.


- Compare pain progression of patients treated with these regimens.

- Compare the qualitative and quantitative toxicity of these regimens in these patients.

- Compare the quality of life, in terms of palliation of metastatic bone pain and
improvement in functional status, of patients treated with these regimens.

- Compare prostate-specific antigen (PSA) response rates in patients treated with these

- Compare objective response in patients with measurable disease treated with these

- Determine whether a 30% reduction in PSA and the slope of PSA from baseline to 3 months
is a surrogate marker for survival in patients treated with these regimens.

- Correlate PSA progression with clinical progression and death in patients treated with
these regimens.

OUTLINE: This is a randomized, double-blind, placebo-controlled, multicenter study. Patients
are stratified according to disease progression (measurable or non-measurable disease
progression vs prostate-specific antigen progression only), use of bisphosphonates at study
entry (yes vs no), worst pain, measured by the Brief Pain Inventory "pain" scale (< grade 4
vs ≥ grade 4), and extraskeletal metastases (yes vs no). Patients are randomized to 1 of 2
treatment arms.

- Arm I: Patients receive docetaxel IV over 1 hour on day 1. Patients also receive oral
atrasentan and oral prednisone once daily on days 1-21. Treatment repeats every 21 days
for up to 12 courses. Patients with stable or responding disease after course 12 may
register for continued oral atrasentan treatment for up to 52 weeks in the absence of
disease progression* or unacceptable toxicity.

- Arm II: Patients receive docetaxel and prednisone as in arm I. Patients also receive
oral placebo once daily on days 1-21. Treatment repeat every 21 days for up to 12
courses. Patients with stable or responding disease after course 12 may register for
continued oral placebo treatment for up to 52 weeks in the absence of disease
progression* or unacceptable toxicity.

NOTE: *Patients with PSA progression alone will be allowed to continue treatment

Quality of life is assessed at baseline, before courses 4, 7, and 10, and then after
completion of study treatment.

After completion of study treatment, patients are followed every 3 months for 1 year and
then every 6 months for up to 3 years from study entry.

PROJECTED ACCRUAL: A total of 930 patients will be accrued for this study within 4 years.

Inclusion Criteria


- Histologically confirmed adenocarcinoma of the prostate

- Stage IV disease (any T, any N, M1b)

- Evidence of bone metastases by bone scan or MRI

- Measurable or nonmeasurable disease

- Soft tissue disease that has been irradiated within the past 2 months is not
assessable as measurable disease

- Hormone-refractory disease despite androgen deprivation and antiandrogen withdrawal,
as defined by 1 of the following criteria:

- Prostate-specific antigen (PSA) progression, defined as 3 consecutive rising PSA
levels* taken ≥ 1 week apart

- PSA ≥ 5 ng/mL NOTE: *If the third confirmatory PSA level is < the second
level, the patient is considered eligible provided a fourth PSA level is >
the second level

- Progression of measurable disease

- Progression of nonmeasurable disease by bone scan

- Must have undergone surgical or medical (e.g., luteinizing hormone-releasing hormone
[LHRH] agonist [e.g., leuprolide or goserelin] or LHRH antagonist therapy) castration

- Patients who have undergone medical castration must continue LHRH agonist or
antagonist therapy during study treatment

- Must have completed 12 courses of blinding protocol treatment (atrasentan/placebo)
AND stopped docetaxel for any reason (including completion of 12 courses) other than
progressive disease

- No symptomatic pleural effusion

- No third space fluid accumulation (e.g., ascites)

- No prior or concurrent brain metastases

- Patients with clinical evidence of brain metastases must have a negative brain
CT scan or MRI within the past 8 weeks



- 18 and over

Performance status

- Zubrod 0-3* NOTE: For a performance status of 3, the cause must be due to pain
secondary to bone metastases

Life expectancy

- Not specified


- Not specified


- Not specified


- Not specified


- Fertile patients must use effective contraception

- Able to take oral medication without crushing, dissolving, or chewing tablets

- No major infection

- No other malignancy within the past 5 years except adequately treated basal cell or
squamous cell skin cancer or stage I or II cancer in complete remission

- No symptomatic sensory neuropathy ≥ grade 2

- No history of hypersensitivity reaction to docetaxel or other drugs formulated with
polysorbate 80

- No other significant, active medical illness that would preclude study treatment or


Biologic therapy

- No more than 1 prior systemic vaccine or biologic therapy

- At least 4 weeks since prior vaccine or biologic therapy and recovered

- No concurrent biological response modifiers

- No concurrent prophylactic colony-stimulating factors


- More than 2 years since prior adjuvant therapy with a single non-taxane-containing
cytotoxic regimen

- No prior cytotoxic chemotherapy for metastatic prostate cancer

- No other concurrent chemotherapy

Endocrine therapy

- See Disease Characteristics

- At least 6 weeks since prior bicalutamide or nilutamide AND has subsequent disease

- At least 4 weeks since prior flutamide or ketoconazole AND has subsequent disease

- Prior or concurrent megestrol for treatment of hot flashes allowed

- No other concurrent corticosteroid or hormonal therapy unless continuing luteinizing
hormone-releasing hormone treatment and/or bisphosphonate therapy


- See Disease Characteristics

- Prior samarium allowed

- At least 3 weeks since prior radiotherapy and recovered

- No prior radiotherapy to ≥ 30% of the bone marrow

- No prior strontium

- No concurrent radiotherapy


- See Disease Characteristics

- At least 3 weeks since prior surgery and recovered


- More than 4 weeks since prior investigational drugs

- Concurrent bisphosphonates allowed provided therapy is started prior to study entry,
dose is maintained during the first 12 weeks of study treatment, and patient meets
criteria for disease progression

- No initiation of bisphosphonates during the first 12 weeks of study treatment

- No concurrent herbal medications or food supplements (e.g., PC-SPES, saw palmetto,
Hypericum perforatum [St. John's wort])

- Concurrent daily vitamins and calcium supplements allowed

- At least 14 days since prior and no concurrent administration of any of the

- Antibiotics (e.g., clarithromycin, erythromycin, troleandomycin, rifampin,
rifabutin, and rifapentine)

- Antifungals (e.g., itraconazole, ketoconazole, fluconazole [doses > 200 mg/day],
and voriconazole)

- Antidepressants (e.g., nefazodone and fluovoxamine)

- Calcium channel blockers (e.g., verapamil, diltiazem)

- Miscellaneous (e.g., amiodarone [no use within 6 months prior to study entry],
grapefruit juice, bitter orange, or modafinil)

- Anticonvulsants (e.g., phenytoin, carbamazepine, phenobarbital, and

- Antibiotics (e.g., rifampin, rifabutin, and rifapentine)

Type of Study:


Study Design:

Allocation: Randomized, Masking: Double-Blind, Primary Purpose: Treatment

Outcome Measure:


Safety Issue:


Principal Investigator

David I. Quinn, MD

Investigator Role:

Study Chair

Investigator Affiliation:

USC/Norris Comprehensive Cancer Center


United States: Federal Government

Study ID:




Start Date:

August 2006

Completion Date:

Related Keywords:

  • Metastatic Cancer
  • Prostate Cancer
  • adenocarcinoma of the prostate
  • stage IV prostate cancer
  • recurrent prostate cancer
  • bone metastases
  • Neoplasm Metastasis
  • Neoplasms
  • Neoplasms, Second Primary
  • Prostatic Neoplasms



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Medical Oncology and Hematology Associates - West Des Moines West Des Moines, Iowa  50266
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St. Francis Comprehensive Cancer Center Topeka, Kansas  66606
Pennington Cancer Center at Baton Rouge General Baton Rouge, Louisiana  70806
Mary Bird Perkins Cancer Center - Baton Rouge Baton Rouge, Louisiana  70809
Medical Center of Louisiana - New Orleans New Orleans, Louisiana  70112
Feist-Weiller Cancer Center at Louisiana State University Health Sciences Shreveport, Louisiana  71130-3932
Hickman Cancer Center at Bixby Medical Center Adrian, Michigan  49221
Mecosta County Medical Center Big Rapids, Michigan  49307
Upper Michigan Cancer Center at Marquette General Hospital Marquette, Michigan  49855
Community Cancer Center of Monroe Monroe, Michigan  48162
Providence Cancer Institute at Providence Hospital - Southfield Campus Southfield, Michigan  48075
Alexandria, Minnesota  56308
Coborn Cancer Center Saint Cloud, Minnesota  56303
CentraCare Clinic - River Campus St. Cloud, Minnesota  56303
Saint Francis Medical Center Cape Girardeau, Missouri  63701
Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center Grand Island, Nebraska  68803
Cancer Institute of New Jersey at Cooper - Voorhees Voorhees, New Jersey  08043
Bismarck Cancer Center Bismarck, North Dakota  58501
Wood County Oncology Center Bowling Green, Ohio  43402
Samaritan North Cancer Care Center Dayton, Ohio  45415
Grandview Hospital Dayton, Ohio  45405
David L. Rike Cancer Center at Miami Valley Hospital Dayton, Ohio  45409
Good Samaritan Hospital Dayton, Ohio  45406
Blanchard Valley Medical Associates Findlay, Ohio  45840
Charles F. Kettering Memorial Hospital Kettering, Ohio  45429
St. Luke's Hospital Maumee, Ohio  43537
Northwest Ohio Oncology Center Maumee, Ohio  43537
Middletown Regional Hospital Middletown, Ohio  45044
Toledo Clinic - Oregon Oregon, Ohio  43616
St. Charles Mercy Hospital Oregon, Ohio  43616
North Coast Cancer Care, Incorporated Sandusky, Ohio  44870
Mercy Hospital of Tiffin Tiffin, Ohio  44883
Toledo Clinic, Incorporated - Main Clinic Toledo, Ohio  43623
UVMC Cancer Care Center at Upper Valley Medical Center Troy, Ohio  45373-1300
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Ruth G. McMillan Cancer Center at Greene Memorial Hospital Xenia, Ohio  45385
Providence Milwaukie Hospital Milwaukie, Oregon  97222
Kaiser Permanente Health Care - Portland Portland, Oregon  97232
Providence Cancer Center at Providence Portland Medical Center Portland, Oregon  97213-2967
Providence St. Vincent Medical Center Portland, Oregon  97225
Bryn Mawr Hospital Bryn Mawr, Pennsylvania  19010
Lankenau Cancer Center at Lankenau Hospital Wynnewood, Pennsylvania  19096
Oncology Services of Aberdeen Aberdeen, South Dakota  57401
Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center Kingsport, Tennessee  37662
UMC Southwest Cancer and Research Center Lubbock, Texas  79415-3364
Cancer Therapy and Research Center San Antonio, Texas  78229
University Hospital - San Antonio San Antonio, Texas  78229
Dixie Regional Medical Center - East Campus Saint George, Utah  84770
Danville Regional Medical Center Danville, Virginia  24541
Minor and James Medical, PLLC Seattle, Washington  98104
Polyclinic First Hill Seattle, Washington  98122
Southwest Washington Medical Center Cancer Center Vancouver, Washington  98668
Holy Family Memorial Medical Center Cancer Care Center Manitowoc, Wisconsin  54221-1450
Welch Cancer Center at Sheridan Memorial Hospital Sheridan, Wyoming  82801
Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital Fairbanks, Alaska  99701
St. Anthony Central Hospital Denver, Colorado  80204-1335
Denver Health Medical Center Denver, Colorado  80204-4507
Montrose Memorial Hospital Cancer Center Montrose, Colorado  81401
Exempla Lutheran Medical Center Wheat Ridge, Colorado  80033
St. Francis Hospital Federal Way, Washington  98003
Cascade Cancer Center at Evergreen Hospital Medical Center Kirkland, Washington  98034-3013
St. Clare Hospital Lakewood, Washington  98499-0998
Providence St. Peter Hospital Regional Cancer Center Olympia, Washington  98506
Good Samaritan Cancer Center Puyallup, Washington  98371
Valley Medical Center Renton, Washington  98055
Allenmore Hospital Tacoma, Washington  98411-0414
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center Ft. Smith, Arkansas  72903
Highland General Hospital Oakland, California  94602
Palo Alto Medical Foundation Palo Alto, California  94301
Middlesex Hospital Cancer Center Middletown, Connecticut  06457
Creticos Cancer Center at Advocate Illinois Masonic Medical Center Chicago, Illinois  60657
Regional Cancer Center at Singing River Hospital Pascagoula, Mississippi  39581
Saint Luke's Hospital Chesterfield, Missouri  63017
Missouri Baptist Cancer Center St. Louis, Missouri  63131
Randolph Hospital Asheboro, North Carolina  27203
Moses Cone Regional Cancer Center at Wesley Long Community Hospital Greensboro, North Carolina  27401
Annie Penn Cancer Center Reidsville, North Carolina  27320
Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital Pittsburgh, Pennsylvania  15224-1791
Praxair Cancer Center at Danbury Hospital Danbury, Connecticut  06810
University of Miami Sylvester Comprehensive Cancer Center - Miami Miami, Florida  33136
West Florida Cancer Institute at West Florida Hospital - Pensacola Pensacola, Florida  32514
Harbin Clinic Cancer Center - Medical Oncology Rome, Georgia  30165
Evanston Hospital Evanston, Illinois  60201-1781
William N. Wishard Memorial Hospital Indianapolis, Indiana  46202
Medical Consultants, PC at Ball Memorial Cancer Center Muncie, Indiana  47303
Reid Hospital & Health Care Services Richmond, Indiana  47374
McFarland Clinic, PC Ames, Iowa  50010
Covenant Cancer Treatment Center Waterloo, Iowa  50702
Hospital District Sixth of Harper County Anthony, Kansas  67003
Cancer Center of Kansas, PA - Chanute Chanute, Kansas  66720
Cancer Center of Kansas, PA - El Dorado El Dorado, Kansas  67042
Cancer Center of Kansas - Fort Scott Fort Scott, Kansas  66701
Cancer Center of Kansas-Independence Independence, Kansas  67301
Cancer Center of Kansas, PA - Kingman Kingman, Kansas  67068
Lawrence Memorial Hospital Lawrence, Kansas  66044
Cancer Center of Kansas, PA - Newton Newton, Kansas  67114
Menorah Medical Center Overland Park, Kansas  66209
Saint Luke's Hospital - South Overland Park, Kansas  66213
Cancer Center of Kansas, PA - Parsons Parsons, Kansas  67357
Cancer Center of Kansas, PA - Pratt Pratt, Kansas  67124
Tammy Walker Cancer Center at Salina Regional Health Center Salina, Kansas  67401
Cancer Center of Kansas, PA - Salina Salina, Kansas  67401
Shawnee Mission Medical Center Shawnee Mission, Kansas  66204
Cotton-O'Neil Cancer Center Topeka, Kansas  66606
Cancer Center of Kansas, PA - Wellington Wellington, Kansas  67152
Cancer Center of Kansas, PA - Wichita Wichita, Kansas  67214
Associates in Womens Health, PA - North Review Wichita, Kansas  67208
Cancer Center of Kansas, PA - Medical Arts Tower Wichita, Kansas  67208
Cancer Center of Kansas, PA - Winfield Winfield, Kansas  67156
Greater Baltimore Medical Center Cancer Center Baltimore, Maryland  21204
Union Hospital Cancer Program at Union Hospital Elkton MD, Maryland  21921
Foote Memorial Hospital Jackson, Michigan  49201
Haematology-Oncology Associates of Ohio and Michigan, PC Lambertville, Michigan  48144
St. Mary Mercy Hospital Livonia, Michigan  48154
Mercy Memorial Hospital - Monroe Monroe, Michigan  48162
St. Joseph Mercy Oakland Pontiac, Michigan  48341-2985
Mercy Regional Cancer Center at Mercy Hospital Port Huron, Michigan  48060
Seton Cancer Institute at Saint Mary's - Saginaw Saginaw, Michigan  48601
Fergus Falls Medical Group, PA Fergus Falls, Minnesota  56537
Willmar Cancer Center at Rice Memorial Hospital Willmar, Minnesota  56201
Truman Medical Center - Hospital Hill Kansas City, Missouri  64108
St. Joseph Medical Center Kansas City, Missouri  64114
Heartland Hematology Oncology Associates, Incorporated Kansas City, Missouri  64118
North Kansas City Hospital Kansas City, Missouri  64116
Saint Luke's Cancer Institute at Saint Luke's Hospital Kansas City, Missouri  64111
Research Medical Center Kansas City, Missouri  64132
Saint Luke's East - Lee's Summit Lee's Summit, Missouri  64086
Liberty Hospital Liberty, Missouri  64068
Heartland Regional Medical Center Saint Joseph, Missouri  64506
Arch Medical Services, Incorporated at Center for Cancer Care and Research Saint Louis, Missouri  63141
Billings Clinic - Downtown Billings, Montana  59107-7000
Bozeman Deaconess Cancer Center Bozeman, Montana  59715
St. James Healthcare Cancer Care Butte, Montana  59701
Great Falls Clinic - Main Facility Great Falls, Montana  59405
Sletten Cancer Institute at Benefis Healthcare Great Falls, Montana  59405
Northern Montana Hospital Havre, Montana  59501
Kalispell Medical Oncology at KRMC Kalispell, Montana  59901
Frederick R. and Betty M. Smith Cancer Treatment Center Sparta, New Jersey  07871
North Coast Cancer Care - Clyde Clyde, Ohio  43410
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center Columbus, Ohio  43210-1240
Hematology Oncology Center Elyria, Ohio  44035
Wayne Hospital Greenville, Ohio  45331
Fisher-Titus Medical Center Norwalk, Ohio  44857
Flower Hospital Cancer Center Sylvania, Ohio  43560
St. Anne Mercy Hospital Toledo, Ohio  43623
Clinton Memorial Hospital Wilmington, Ohio  45177
Cleo Craig Cancer Research Clinic Lawton, Oklahoma  73505
Adventist Medical Center Portland, Oregon  97216
Geisinger Hazleton Cancer Center Hazleton, Pennsylvania  18201
Guthrie Cancer Center at Guthrie Clinic Sayre Sayre, Pennsylvania  18840
Hematology and Oncology Associates of Northeastern Pennsylvania Scranton, Pennsylvania  18510
Sandra L. Maxwell Cancer Center Cedar City, Utah  84720
Jon and Karen Huntsman Cancer Center at Intermountain Medical Center Murray, Utah  84157
Val and Ann Browning Cancer Center at McKay-Dee Hospital Center Ogden, Utah  84403
Fredericksburg Oncology, Incorporated Fredericksburg, Virginia  22401
Southwest Virginia Regional Cancer Center at Wellmonth Health Norton, Virginia  24273
St. Joseph Cancer Center Bellingham, Washington  98225
Providence Centralia Hospital Centralia, Washington  98531-9027
Columbia Basin Hematology Kennewick, Washington  99336
Harrison Poulsbo Hematology and Onocology Poulsbo, Washington  98370
Evergreen Hematology and Oncology, PS Spokane, Washington  99218
Franciscan Cancer Center at St. Joseph Medical Center Tacoma, Washington  98405-3004
Wenatchee Valley Medical Center Wenatchee, Washington  98801-2028
Community Comprehensive Cancer Center at Camden-Clark Memorial Hospital Parkersburg, West Virginia  26102
Schiffler Cancer Center at Wheeling Hospital Wheeling, West Virginia  26003
Marshfield Clinic - Chippewa Center Chippewa Falls, Wisconsin  54729
Marshfield Clinic Cancer Care at Regional Cancer Center Eau Claire, Wisconsin  54701
Vince Lombardi Cancer Center at Aurora Lakeland Medical Center - Elkhorn Elkhorn, Wisconsin  53121
Oncology Alliance - Franklin Franklin, Wisconsin  53132
Oncology Alliance, SC - Milwaukee - East Glendale, Wisconsin  53212-1038
UW Cancer Center Johnson Creek Johnson Creek, Wisconsin  53038
Oncology Alliance - Kenosha South Kenosha, Wisconsin  53143
Saint Joseph's Hospital Marshfield, Wisconsin  54449
Oncology Alliance, SC - Milwaukee - South Milwaukee, Wisconsin  53215
Medical Consultants, Limited Milwaukee, Wisconsin  53215
Marshfield Clinic - Lakeland Center Minocqua, Wisconsin  54548
Ministry Medical Group at Saint Mary's Hospital Rhinelander, Wisconsin  54501
Saint Michael's Hospital Cancer Center Stevens Point, Wisconsin  54481
Marshfield Clinic - Wausau Center Wausau, Wisconsin  54401
Oncology Alliance, SC - Milwaukee - West Wauwatosa, Wisconsin  53226
Marshfield Clinic - Weston Center Weston, Wisconsin  54476
Marshfield Clinic - Wisconsin Rapids Center Wisconsin Rapids, Wisconsin  54494
Rocky Mountain Oncology Casper, Wyoming  82609
Mid Dakota Clinic, PC Bismarck, North Dakota  58501
Regional Cancer Center at Memorial Medical Center Springfield, Illinois  62781-0001
Auburn Regional Center for Cancer Care Auburn, Washington  98002
Community Hospital Munster, Indiana  46321
Ben Taub General Hospital Houston, Texas  77030
Methodist Hospital Houston, Texas  77030
Queen's Cancer Institute at Queen's Medical Center Honolulu, Hawaii  96813
MetroWest Medical Center - Framingham Union Hospital Framingham, Massachusetts  01702
Good Samaritan Cancer Center at Good Samaritan Hospital Kearney, Nebraska  68848-1990
Rutherford Hospital Rutherfordton, North Carolina  28139
Easton Regional Cancer Center at Easton Hospital Easton, Pennsylvania  18042
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center Spartanburg, South Carolina  29303
Kinston Medical Specialists Kinston, North Carolina  28501
Glendale Memorial Hospital Comprehensive Cancer Center Glendale, California  91204
Manchester Memorial Hospital Manchester, Connecticut  06040-4188
Resurrection Medical Center Chicago, Illinois  60631
Sherman Hospital Elgin, Illinois  60120-2198
Freeman Cancer Institute at Freeman Health System Joplin, Missouri  64803-2644
McLeod Regional Medical Center Florence, South Carolina  29501
Nalitt Cancer Institute at Staten Island University Hospital Staten Island, New York  10305
La Grange Memorial Hospital La Grange, Illinois  60525
Cedar Valley Medical Specialists, PC - West Ridgeway Avenue Waterloo, Iowa  50702
Lacks Cancer Center at Saint Mary's Health Care Grand Rapids, Michigan  49503
Metro Health Hospital Grand Rapids, Michigan  49506
Great Falls, Montana  59405
Guardian Oncology and Center for Wellness Missoula, Montana  59804
Lakes Region General Hospital Laconia, New Hampshire  03246
Rockwood Clinic Cancer Treatment Center Spokane, Washington  99204-2967
University of Wisconcin Cancer Center at Aspirus Wausau Hospital Wausau, Wisconsin  54401
Doctors Medical Center - San Pablo Campus San Pablo, California  94806
Boston University Cancer Research Center Boston, Massachusetts  02118
St. Vincent Healthcare Cancer Care Services Billings, Montana  59101
University of Tennessee Cancer Institute - Memphis Memphis, Tennessee  38104
Desert Regional Medical Center Comprehensive Cancer Center Palm Springs, California  92262
Independence Regional Health Center Independence, Missouri  64050
Parvin Radiation Oncology Kansas City, Missouri  64116
Midwest Hematology Oncology Group, Incorporated Saint Louis, Missouri  63109
Lynchburg Hematology-Oncology Clinic Lynchburg, Virginia  24501
Mercy General Hospital Sacramento, California  95819
Providence Cancer Center at Providence Hospital Mobile, Alabama  36608
East Bay Radiation Oncology Center Castro Valley, California  94546
Contra Costa Regional Medical Center Martinez, California  94553-3156
Tibotec Therapeutics - Division of Ortho Biotech Products, LP Marysville, California  95901
El Camino Hospital Cancer Center Mountain View, California  94040
Larry G Strieff MD Medical Corporation Oakland, California  94609
Tom K Lee, Incorporated Oakland, California  94609
Bay Area Breast Surgeons, Incorporated Oakland, California  94609
Valley Medical Oncology Consultants - Pleasanton Pleasanton, California  94588
Tahoe Forest Cancer Center Truckee, California  96161
Connecticut Oncology & Hematology - Torrington Torrington, Connecticut  06790
Kapiolani Medical Center at Pali Momi Aiea, Hawaii  96701
Kapiolani Medical Center for Women and Children Honolulu, Hawaii  96826
Straub Clinic and Hospital, Incorporated Honolulu, Hawaii  96813
Hawaii Medical Center - East Honolulu, Hawaii  96817
OnCare Hawaii, Incorporated - Kuakini Honolulu, Hawaii  96817
OnCare Hawaii, Incorporated - Lusitana Honolulu, Hawaii  96813
Maui Memorial Medical Center Wailuku, Hawaii  96793
Pacific Cancer Institute - Maui Wailuku, Hawaii  96793
Alexian Brothers Radiation Oncology Elk Grove Village, Illinois  60007
Elmhurst Memorial Hospital Elmhurst, Illinois  60126
Veterans Affairs Medical Center - Indianapolis Indianapolis, Indiana  46202
Iowa Blood and Cancer Care Cedar Rapids, Iowa  52402
Mercy General Health Partners Muskegon, Michigan  49443
New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care Concord, New Hampshire  03301
Center for Cancer Care at Exeter Hospital Exeter, New Hampshire  03833
New Hampshire Oncology - Hematology, PA - Hooksett Hooksett, New Hampshire  03106
Valley Hospital - Ridgewood Ridgewood, New Jersey  07450
Trinity CancerCare Center Minot, North Dakota  58701
United States Air Force Medical Center - Wright-Patterson Wright-Patterson AFB, Ohio  45433-5529
Bay Area Hospital Coos Bay, Oregon  97420
Cancer Center of Paoli Memorial Hospital Paoli, Pennsylvania  19301-1792
CCOP - Main Line Health Wynnewood, Pennsylvania  19096
AnMed Cancer Center Anderson, South Carolina  29621
Fountain Valley, California  92708
Medcenter One Hospital Cancer Care Center Bismarck, North Dakota  58501
St. Alexius Medical Center Cancer Center Bismarck, North Dakota  58502
University of Colorado Cancer Center at UC Health Sciences Center Aurora, Colorado  80045
Center for Cancer Care at Goshen General Hospital Goshen, Indiana  46526
Callahan Cancer Center at Great Plains Regional Medical Center North Platte, Nebraska  69103
Jersey Shore Cancer Center at Jersey Shore University Medical Center Neptune, New Jersey  07754-0397
Valley Medical Oncology Consultants - Castro Valley Castro Valley, California  94546
Valley Medical Oncology Fremont, California  94538
Cancer Care Associates Fresno, California  93720
Integrated Community Oncology Network - Orange Park Orange Park, Florida  32073
Mount Sinai Hospital Medical Center Chicago, Illinois  60608
Provena St. Mary's Regional Cancer Center - Kankakee Kankakee, Illinois  60901
Heartland Oncology and Hematology Council Bluffs, Iowa  51503
Alamance Cancer Center at Alamance Regional Medical Center Burlington, North Carolina  27216
Marion L. Shepard Cancer Center at Beaufort County Hospital Washington, North Carolina  27889
St. Luke's Texas Cancer Institute at St. Luke's Episcopal Hospital Houston, Texas  77030
Peninsula Cancer Institute - Newport News Office Newport News, Virginia  23601
Shore Regional Cancer Center at Memorial Hospital - Easton Easton, Maryland  21601
Community Hospital of the Monterey Peninsula Comprehensive Cancer Center Monterey, California  93940
Camino Medical Group - Treatment Center Mountain View, California  94040
Falck Cancer Center at Arnot Ogden Medical Center Elmira, New York  14905
Clarian Arnett Cancer Care Lafayette, Indiana  47904
Bassett Healthcare Regional Cancer Program at Mary Imogene Bassett Hospital Cooperstown, New York  13326
Nevada Cancer Institute Las Vegas, Nevada  89135
Renown Institute for Cancer at Renown Regional Medical Center Reno, Nevada  89502
Riverside Middle Peninsula Cancer Center Gloucester, Virginia  23061
Peninsula Cancer Institute - Williamsburg Office Williamsburg, Virginia  23185
Shaw Regional Cancer Center Edwards, Colorado  81632
Langlade Memorial Hospital Antigo, Wisconsin  54409
Southeastern Medical Oncology Center - Goldsboro Goldsboro, North Carolina  27534
Valley View Hospital Cancer Center Glenwood Springs, Colorado  81601
Central Dupage Cancer Center Warrenville, Illinois  60555
Clemens Regional Medical Center Mount Clemens, Michigan  48043
Riverview UW Cancer Center at Riverview Hospital Wisconsin Rapids, Wisconsin  54494
Northeast Georgia Cancer Care, LLC - Medical Oncology Athens, Georgia  30607
Pacific Medical Center Seattle, Washington  98104
Highland Clinic Shreveport, Louisiana  71105
Space Coast Medical Associates Cocoa Beach, Florida  32931
Bloomington Hospital Regional Cancer Institute Bloomington, Indiana  47403
Cancer Centers of Central Florida, PA Leesburg, Florida  34788
Northern Westchester Hospital Mount Kisco, New York  10549
Cookeville Regional Medical Center Cookeville, Tennessee  38501