Randomized Phase III Study of Standard CHOP (S-CHOP) Versus Biweekly CHOP (Bi-CHOP) in Aggressive Non-Hodgkin's Lymphoma (JCOG9809)
The purpose of JCOG9809 was to determine whether treatment results of aggressive NHL could
be improved by shortening intervals of CHOP chemotherapy with the prophylactic use of G-CSF.
The primary endpoint was Progression Free Survival (PFS), and the planned accrual was 450.
Until December, 2002, 323 patients with advanced aggressive NHL were randomized to standard
CHOP arm (CHOP x 8, every three weeks) and biweekly CHOP arm (CHOP x 8, every two weeks).
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Progression free survival
Tomomitsu Hotta, MD, PhD
Japan: Ministry of Health, Labor and Welfare