Inclusion Criteria

Inclusion criteria

- A confirmed diagnosis of multiple myeloma in patients who have failed at least two
prior lines of therapy

- Adequate bone marrow and hepatic functions

- Performance status (PS) less than 2 (Eastern Cooperative Oncology Group [ECOG] scale)

- Estimated life expectancy greater than 3 months

Exclusion criteria

- Anti-cancer therapy within the last 4 weeks

- Co-existing active infection or any co-existing medical condition likely to interfere
with trial procedures

- Significant cardiovascular disease

- A marked baseline prolongation of QT/QTc interval

- Patients with renal insufficiency

- Non-secretory multiple myeloma or symptomatic amyloidosis

- Pregnant or breast-feeding women

- Women of childbearing age and potential who do not use effective contraception

- Known HIV positivity