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Establishing a Tumor Bank and Initial Analysis of Germline and Tumor-Related Genetic Alterations in Families With Multiple Lymphoproliferative Malignancies


N/A
18 Years
N/A
Open (Enrolling)
Both
Non-Hodgkin's Lymphoma, Hodgkin's Disease, Leukemia, Lymphocytic, Chronic, Lymphoproliferative Disorders

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Trial Information

Establishing a Tumor Bank and Initial Analysis of Germline and Tumor-Related Genetic Alterations in Families With Multiple Lymphoproliferative Malignancies


- Patients who participate will be asked to complete detailed family and medical history
questionnaires initially, with a follow-up questionnaire every year.

- Patients will be asked to supply a blood sample and possibly a mouthwash sample, both
of which can be done by mail.

- Patients will be asked to consent to the release of their lymphoma tissue block for the
purposes of the study.

- Patients will be given letters of invitation for their affected relatives to invite
them to participate.


Inclusion Criteria:



- Any individual diagnosed with non-Hodgkin's lymphoma or Hodgkin's disease or chronic
lymphocytic leukemia (CLL), who has a 1st degree relative (parent, sibling or child)
with a lymphoproliferative disorder; or families in which the individual has a
lymphoproliferative disorder, and an unusual clustering of frequent or premature
solid tumors is also observed.

- Family members of the individual, either affected or unaffected with lymphoma, who
are contacted by the individual and agree to participate in the study.

- Deceased family members may be included in the study. Public records such as death
certificates may be used to confirm the history. Consent for medical records or
tissue blocks will be obtained from the deceased family member's next of kin. The
hierarchy of relatives defined as next of kin is spouse, offspring, parents and
siblings. Archived tissue samples may be used for genetic research.

- Age > 18 years

Exclusion Criteria:

- Subjects without a family history of lymphoma

Type of Study:

Observational

Study Design:

Observational Model: Family-Based, Time Perspective: Prospective

Outcome Measure:

Genetic factors that contribute to the development of lymphomas and CLL

Outcome Time Frame:

Indefinite

Safety Issue:

No

Principal Investigator

Jennifer R. Brown, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Dana-Farber Cancer Institute

Authority:

United States: Institutional Review Board

Study ID:

04-165

NCT ID:

NCT00131014

Start Date:

August 2004

Completion Date:

January 2020

Related Keywords:

  • Non-Hodgkin's Lymphoma
  • Hodgkin's Disease
  • Leukemia, Lymphocytic, Chronic
  • Lymphoproliferative Disorders
  • Non-Hodgkin's Lymphoma
  • Hodgkin's disease
  • Chronic Lymphocytic Leukemia
  • Lymphoproliferative disorder
  • Genetics
  • Hodgkin Disease
  • Leukemia
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Leukemia, Lymphoid
  • Lymphoma
  • Lymphoma, Non-Hodgkin
  • Lymphoproliferative Disorders

Name

Location

Dana-Farber Cancer InstituteBoston, Massachusetts  02115