Inclusion Criteria:

- Male and female patients 18 years of age or older, with a diagnosis of advanced solid
tumor for which no curative or other treatment of higher priority is available

- Karnofsky Performance Status (KPS) equal to or greater than 70%

- Normal liver function tests (aspartate transaminase [AST] or alanine transaminase
[ALT] equal to or less than 2 x upper limit of normal [ULN])

- Total bilirubin equal to or less than 1.5 x ULN

- Calculated creatinine clearance equal to or greater than 50 mL/min

- Normal serum calcium

Exclusion Criteria:

- Patients with significant cardiac disease

- Equal to or greater than Grade 2 neuropathy

- Active hepatitis

- HIV infection

- Secondary malignancy

- Transfusion-dependent or received extensive radiation therapy, systemic chemotherapy,
or other antineoplastic therapy within 4 weeks of enrollment

- Patients taking concomitant medications having inhibitory or inducing activity for
CYP 3A4