Inclusion Criteria

DISEASE CHARACTERISTICS:

•Healthy participants

- Deemed to be in good general health by history and physical examination

•Resident of Guanacaste Province of Costa Rica and surrounding areas

- Must remain a resident for ≥ 6 months after the first study vaccination

PATIENT CHARACTERISTICS:

Age

- 18 to 25

Performance status

•Not specified

Life expectancy

•Not specified

Hematopoietic

•Not specified

Hepatic

- No history of chronic hepatitis requiring treatment

- No acute or chronic clinically significant hepatic function abnormality by physical
examination or laboratory findings

- No known history of hepatitis A infection

Renal

- No history of kidney disease requiring treatment

- No acute or chronic clinically significant kidney function abnormality by physical
examination or laboratory findings

Cardiovascular

- No acute or chronic clinically significant cardiovascular function abnormality by
physical examination or laboratory findings Pulmonary

- No acute or chronic clinically significant pulmonary function abnormality by physical
examination or laboratory findings Immunology

- No history of allergic disease

- No history of autoimmune disorder requiring treatment

- No history of allergic reaction (e.g., difficulty breathing) to any vaccine

- No suspected allergy or reaction likely to be exacerbated by a component of the study
vaccines (e.g., 2-phenoxyethanol or neomycin)

- No hypersensitivity to latex

- No diagnosis or suspicion of any immunodeficient condition by medical history or
physical examination Other

- Not pregnant or nursing

◦No delivery within the past 3 months

- Negative pregnancy test

- Fertile patients must use effective contraception for 30 days before, during, and for
60 days after completion of study treatment

- Able to speak or understand Spanish

- Mentally competent

- Able to undergo pelvic exam (i.e., no heavy bleeding [menstruation or otherwise] or
heavy vaginal discharge)

- No history of cancer requiring treatment

- No history of diabetes requiring treatment

- No history of other chronic conditions requiring treatment

- No acute or chronic clinically significant neurologic function abnormality by
physical examination or laboratory findings

- No other acute disease

- No fever ≥ 37.5º C

PRIOR CONCURRENT THERAPY:

Biologic therapy

- More than 6 months since prior chronic administration (i.e., > 14 days) of
immune-modulating drugs

- More than 90 days since prior immunoglobulins

- More than 30 days since prior and no other concurrent investigational or
non-registered vaccines

- More than 30 days since prior registered vaccines

- More than 8 days since prior routine meningococcal, hepatitis B, influenza, or
diphtheria/tetanus vaccine

- No prior vaccination against hepatitis A

- No prior vaccination against human papillomavirus

- No prior monophosphoryl lipid A or AS04 adjuvant

Chemotherapy

•Not specified

Endocrine therapy

- More than 6 months since prior chronic administration (i.e., > 14 days) of
corticosteroids (e.g., ≥ 0.5 mg/kg/day of prednisone or equivalent)

- Concurrent inhaled or topical steroids allowed

Radiotherapy

•Not specified

Surgery

•No prior hysterectomy

Other

- More than 6 months since prior chronic administration (i.e., > 14 days) of
immunosuppressants

- More than 30 days since prior and no other concurrent investigational or
non-registered drugs