Inclusion Criteria

Main inclusion criteria:

1. Diagnosis of small cell lung cancer.

2. Patients must have had one prior chemotherapy regimen which must have included either
cisplatin or carboplatin.

[Additional eligibility criteria apply.]

Exclusion Criteria:

- Prior radiotherapy that included > 30% of the bone marrow (i.e., the whole of the
pelvis or half of the spine).

- Significant chronic or recent acute gastrointestinal disorder with diarrhea as a
major symptom.

- Significant heart disease.

- Uncontrolled, untreated, unstable, or symptomatic brain tumors or central nervous
system disease.

- Grade 2+ peripheral neuropathy (a condition caused by damage to the nerves in the
peripheral nervous system).

[Additional exclusion criteria apply.]