Trial Information

Comparison of Aerobic Versus Resistance Exercise Training in Enhancing Quality of Life in Early Stage Breast Cancer Survivors Receiving Chemotherapy: A Multi-Centre Randomized Trial

The study was a prospective, three-armed, randomized controlled trial. Participants were
stratified by site (Edmonton, Ottawa, and Vancouver) and planned chemotherapy protocol
(taxane-based versus nontaxane-based) and randomly assigned to AET, RET, or usual care (UC)
in a 1:1:1 ratio using a random-numbers table. Participants assigned to the AET group were
asked to perform aerobic exercise three times per week on a recumbent or upright cycle
ergometer, treadmill, or elliptical. Exercise duration began at 15 minutes for weeks 0
through 2, and then systematically increased by 5 minutes every three weeks thereafter to 45
minutes for weeks 18 and beyond. Exercise intensity began at 60% of VO2max for weeks 0
through 2 and then systematically increased by 10% every 6 weeks thereafter to 80% of VO2max
for weeks 12 and beyond. Warm-up and cool-down periods consisted of 5 minutes of aerobic
activity at the power output of the ventilatory equivalent for oxygen (approximately 50% of
peak oxygen consumption). Participants assigned to the RET group were asked to perform
resistance exercise three times per week, which consisted of two sets of 10 repetitions of 9
different exercises performed at 60-70% of 1-repetition maximum. The specific exercises
were: leg extension, leg curl, calf raises, chest press, latissimus pulldown, overhead
press, triceps extension, biceps curls, and modified curl-ups. Resistance was increased by
approximately 10% or the next weight level when the participant was able to complete 12
repetitions per set without difficulty.