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Comparison of Aerobic Versus Resistance Exercise Training in Enhancing Quality of Life in Early Stage Breast Cancer Survivors Receiving Chemotherapy: A Multi-Centre Randomized Trial


Phase 3
N/A
N/A
Not Enrolling
Female
Breast Neoplasms

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Trial Information

Comparison of Aerobic Versus Resistance Exercise Training in Enhancing Quality of Life in Early Stage Breast Cancer Survivors Receiving Chemotherapy: A Multi-Centre Randomized Trial


The study was a prospective, three-armed, randomized controlled trial. Participants were
stratified by site (Edmonton, Ottawa, and Vancouver) and planned chemotherapy protocol
(taxane-based versus nontaxane-based) and randomly assigned to AET, RET, or usual care (UC)
in a 1:1:1 ratio using a random-numbers table. Participants assigned to the AET group were
asked to perform aerobic exercise three times per week on a recumbent or upright cycle
ergometer, treadmill, or elliptical. Exercise duration began at 15 minutes for weeks 0
through 2, and then systematically increased by 5 minutes every three weeks thereafter to 45
minutes for weeks 18 and beyond. Exercise intensity began at 60% of VO2max for weeks 0
through 2 and then systematically increased by 10% every 6 weeks thereafter to 80% of VO2max
for weeks 12 and beyond. Warm-up and cool-down periods consisted of 5 minutes of aerobic
activity at the power output of the ventilatory equivalent for oxygen (approximately 50% of
peak oxygen consumption). Participants assigned to the RET group were asked to perform
resistance exercise three times per week, which consisted of two sets of 10 repetitions of 9
different exercises performed at 60-70% of 1-repetition maximum. The specific exercises
were: leg extension, leg curl, calf raises, chest press, latissimus pulldown, overhead
press, triceps extension, biceps curls, and modified curl-ups. Resistance was increased by
approximately 10% or the next weight level when the participant was able to complete 12
repetitions per set without difficulty.


Inclusion Criteria:



- Breast cancer early stage I ā€“IIIA

- Completed axillary surgery

- Scheduled to receive adjuvant chemotherapy for 9 ā€“ 24 weeks

- Approval of the treating oncologist

- Able to understand and provide written informed consent in English or French (Ottawa)

- 18+ years of age

- No uncontrolled hypertension, cardiac illness, psychiatric condition

- No contraindication to exercise as determined by a fitness test

Exclusion Criteria:

- Pregnant.

- Unwilling to accept randomization.

- Any medical condition that would be a contraindication to exercise. The clinicians
will make this decision.

- Unwilling to travel to/participate in the exercise program as defined by the
protocol.

- Previous chemotherapy (previous cancer is NOT an exclusion criteria).

- Cancer recurrence.

- Planned/known absence of greater than 2 weeks during the intended study period.

- Previous therapy for known breast cancer.

- Those who have had TRAM (i.e., Transabdominal Rectus Abdominus Muscle Reconstructive
Surgery) done.

- Moderate lymphedema (>20% or >200mL difference between the affected arm and the
unaffected arm).

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Outcome Measure:

Quality of Life

Principal Investigator

Kerry S Courneya, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Alberta

Authority:

Canada: Health Canada

Study ID:

ETH-02-70-85

NCT ID:

NCT00115713

Start Date:

April 2003

Completion Date:

December 2005

Related Keywords:

  • Breast Neoplasms
  • Aerobic Exercise
  • Weight Lifting
  • Breast Cancer
  • Quality of Life
  • Breast Neoplasms
  • Neoplasms

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